9H-Pyrido[3,4-b]indole-1-carboxylic acid

Product Name: 9H-Pyrido[3,4-b]indole-1-carboxylic acid
CAS No.: 26052-96-0
Chemical Name: 9H-Pyrido[3,4-b]indole-1-carboxylic acid
Synonyms: β-Carboline-1-carboxylic Acid;??-Carboline-1-carboxylic acid;Carboline 1-carboxylic acid, β-;9H-pyrido[3,4-b]indol-1-carboxylic acid;9H-Pyrido[3,4-b]indole-1-carboxylic acid
CBNumber: CB33076827
Molecular Formula: C12H8N2O2
Formula Weight: 212.2
MOL File: 26052-96-0.mol

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9H-Pyrido[3,4-b]indole-1-carboxylic acid Property

Boiling point:: 538.7±30.0 °C(Predicted)
Density: 1.497±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: soluble; Methanol: soluble
form: A solid
pka: 0.83±0.30(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B530605
Product name: 9H-pyrido[3,4-b]indole-1-carboxylicAcid
Packaging: 100mg
Price: $265
Updated: 2021/12/16

AK Scientific

Product number: 9928CV
Product name: 9H-Pyrido[3,4-b]indole-1-carboxylicacid
Packaging: 100mg
Price: $328
Updated: 2021/12/16

AccelPharmtech

Product number: P5040
Product name: 9H-Pyrido[3,4-b]indole-1-carboxylicacid
Purity: 97.00%
Packaging: 1G
Price: $2280
Updated: 2021/12/16

AccelPharmtech

Product number: P5040
Product name: 9H-Pyrido[3,4-b]indole-1-carboxylicacid
Purity: 97.00%
Packaging: 5G
Price: $3900
Updated: 2021/12/16

AccelPharmtech

Product number: P5040
Product name: 9H-Pyrido[3,4-b]indole-1-carboxylicacid
Purity: 97.00%
Packaging: 25G
Price: $7320
Updated: 2021/12/16

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9H-Pyrido[3,4-b]indole-1-carboxylic acid Chemical Properties,Usage,Production

Biological Activity

β-Carboline-1-carboxylic acid is an alkaloid that has been found in P. quassioides and has diverse biological activities.1,2,3 It reduces LPS-induced increases in MCP-1, TNF-α, IL-6, and IL-1β levels in RAW 264.7 cells when used at a concentration of 15 μg/ml and inhibits the epithelial-to-mesenchymal transition (EMT) induced by TGF-β1 in A549 cells.2 β-Carboline-1-carboxylic acid induces cytotoxicity in CT26.WT, K562, and SGC-7901 cells (IC50s = 14.96, 22.11, and 19.7 μg/ml, respectively) but not HepG2 or A549 cells (IC50s = 36.41 and 41.51 μg/ml, respectively).1 It also inhibits cAMP phosphodiesterase with an IC50 value of 96 μM.3

References

1.Lai, Z.-Q., Liu, W.-H., Ip, S.-P., et al.Seven alkaloids from Picrasma quassioides and their cytotoxic activitiesChem. Nat. Compd.50(5)884-888(2014) 2.Cui, Y., Jiang, L., Yu, R., et al.β-carboline alkaloids attenuate bleomycin induced pulmonary fibrosis in mice through inhibiting NF-kb/p65 phosphorylation and epithelial-mesenchymal transitionJ. Ethnopharmacol.243112096(2019) 3.Sung, Y.-I., Koike, K., Nikaido, T., et al.Inhibitors of cyclic AMP phosphodiesterase in Picrasma quassioides BENNET, and inhibitory activities of related β-carboline alkaloidsChem. Pharm. Bull. (Tokyo)32(5)1872-1877(1984)

9H-Pyrido[3,4-b]indole-1-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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9H-Pyrido[3,4-b]indole-1-carboxylic acid Suppliers

China 8 United States 2 Global 10

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26052-96-0