4-CYANO-2-METHOXYPYRIDINE

Product Name: 4-CYANO-2-METHOXYPYRIDINE
CAS No.: 72716-86-0
Chemical Name: 4-CYANO-2-METHOXYPYRIDINE
Synonyms: 4-CYANO-2-METHOXYPYRIDINE;2-METHOXYISONICOTINONITRILE;4-Cyano-2-methoxypyridine 98%;2-Methoxyisonicotinonitrile 98%;2-Methoxy-4-Pyridinecarbonitrile;4-Pyridinecarbonitrile, 2-methoxy-;2-cyano-2-Methoxy-1,2-dihydropyridine-4-carboxylic acid
CBNumber: CB3308231
Molecular Formula: C7H6N2O
Formula Weight: 134.14
MOL File: 72716-86-0.mol

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4-CYANO-2-METHOXYPYRIDINE Property

Melting point:: 88-92
Boiling point:: 207.1±25.0 °C(Predicted)
Density: 1.16±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
form: solid
pka: 0.04±0.10(Predicted)
color: White

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Safety

Hazard Codes: Xi
Hazard Note: Irritant
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC

Product number: C982233
Product name: 4-Cyano-2-methoxypyridine
Packaging: 5g
Price: $165
Updated: 2021/12/16

Matrix Scientific

Product number: 085022
Product name: 2-Methoxyisonicotinonitrile
Purity: 97%
Packaging: 1g
Price: $194
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: C13614
Product name: 4-Cyano-2-methoxypyridine
Purity: 97%
Packaging: 1g
Price: $19
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: C13614
Product name: 4-Cyano-2-methoxypyridine
Purity: 97%
Packaging: 5g
Price: $56
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H37-1-5N
Product name: 4-Cyano-2-methoxypyridine
Purity: 98%
Packaging: 25g
Price: $400
Updated: 2021/12/16

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4-CYANO-2-METHOXYPYRIDINE Chemical Properties,Usage,Production

Uses

4-Cyano-2-methoxypyridine is a reagent used in the synthesis of hydroxypyridone derivatives which are bioisosters of capsain.

Synthesis

33252-30-1

124-41-4

72716-86-0

General procedure for the synthesis of 4-cyano-2-methoxypyridine from 2-chloro-4-cyanopyridine and sodium methanol: To a solution of 2-chloro-4-cyanopyridine (1.38 g, 10 mmol) in dioxane (10 mL) was added a methanolic solution of sodium methanol (25%, 2.27 g, 10.5 mmol). The reaction mixture was heated to reflux for 5 h, followed by cooling to room temperature and standing overnight in a refrigerator. The precipitate was collected by filtration and washed with methanol. The filtrate was concentrated to about 10 mL and water (100 mL) was added. The precipitate was collected by filtration again and washed with water to give 4-cyano-2-methoxypyridine (1.93 g, 72% yield) as a white solid. Mass spectrum (electrospray positive ion mode) m/z 135 [M + H]+.

References

[1] Journal of Medicinal Chemistry, 2008, vol. 51, # 21, p. 6631 - 6634
[2] Patent: WO2006/9889, 2006, A1. Location in patent: Page/Page column 54
[3] Patent: WO2006/33011, 2006, A1. Location in patent: Page/Page column 28
[4] Journal of Medicinal Chemistry, 2017, vol. 60, # 7, p. 2669 - 2684
[5] European Journal of Medicinal Chemistry, 1993, vol. 28, # 7-8, p. 601 - 608

4-CYANO-2-METHOXYPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-CYANO-2-METHOXYPYRIDINE Suppliers

China 86 Germany 1 India 1 Ukraine 1 United Kingdom 2 United States 11 Global 102

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Shanghai Raise Chemical Technology Co.,Ltd

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View Lastest Price from 4-CYANO-2-METHOXYPYRIDINE manufacturers

Career Henan Chemical Co

Product: 4-CYANO-2-METHOXYPYRIDINE 72716-86-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%-99.9%
Supply Ability: 100kg
Release date: 2020-01-10

72716-86-0, 4-CYANO-2-METHOXYPYRIDINERelated Search:

4-CYANO-2-METHOXYPYRIDINE 2-Cyano-6-methoxypyridine 2-Amino-3-cyano-4-methoxypyridine 3-CYANO-2-METHOXYPYRIDINE,3-Cyano-2-methoxypyridine 98% 5-CYANO-2-METHOXYPYRIDINE 2-Amino-5-bromo-3-cyano-4-methoxypyridine 2-Cyano-4-methoxypyridine 2-Methoxypyridine 3-IODO-2-METHOXYISONICOTINONITRILE tert-butyl 4-[(4-cyano-2-pyridinyl)oxy]tetrahydro-1(2H)-pyridinecarboxylate 2-(benzyloxy)isonicotinonitrile 2-CYANO-3-METHOXYPYRIDINE 2-Amino-5-bromo-4-methoxypyridine-3-carbonitrile, 2-Amino-5-bromo-3-cyano-4-methoxypyridine 3-CYANO-2-METHOXYPYRIDINE-5-BORONIC ACID, PINACOL ESTER 3-Cyano-5-methoxypyridine 2-HYDROXY-3-CYANO-4-METHOXYPYRIDINE 2-[4-(cyanomethyl)phenoxy]isonicotinonitrile 2-(2H-1,3-benzodioxol-5-yloxy)pyridine-4-carbonitrile

4-CYANO-2-METHOXYPYRIDINE

2-METHOXYISONICOTINONITRILE

4-Cyano-2-methoxypyridine 98%

2-cyano-2-Methoxy-1,2-dihydropyridine-4-carboxylic acid

2-Methoxy-4-Pyridinecarbonitrile

4-Pyridinecarbonitrile, 2-methoxy-

2-Methoxyisonicotinonitrile 98%

72716-86-0

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Carboxes

Pyridines