5,5'-((1E,1'E)-1,4-phenylenebis(ethene-2,1-diyl))bis(2-hydroxybenzoic acid)
- Product Name
- 5,5'-((1E,1'E)-1,4-phenylenebis(ethene-2,1-diyl))bis(2-hydroxybenzoic acid)
- CAS No.
- 215294-98-7
- Chemical Name
- 5,5'-((1E,1'E)-1,4-phenylenebis(ethene-2,1-diyl))bis(2-hydroxybenzoic acid)
- Synonyms
- X-34;X-34 >=90% (HPLC);Benzoic acid, 3,3'-(1,4-phenylenedi-2,1-ethenediyl)bis[6-hydroxy-;5,5'-((1E,1'E)-1,4-phenylenebis(ethene-2,1-diyl))bis(2-hydroxybenzoic acid)
- CBNumber
- CB33084790
- Molecular Formula
- C24H18O6
- Formula Weight
- 402.4
- MOL File
- 215294-98-7.mol
5,5'-((1E,1'E)-1,4-phenylenebis(ethene-2,1-diyl))bis(2-hydroxybenzoic acid) Property
- Boiling point:
- 669.9±55.0 °C(Predicted)
- Density
- 1.448±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: 2.0mg/mL, clear
- form
- Solid
- pka
- 2.85±0.10(Predicted)
- color
- Light yellow to yellow
N-Bromosuccinimide Price
- Product number
- SML1954
- Product name
- X-34
- Purity
- ≥90% (HPLC)
- Packaging
- 5 mg
- Price
- $102.6
- Updated
- 2025/07/31
- Product number
- SML1954
- Product name
- X-34
- Purity
- ≥90% (HPLC)
- Packaging
- 25 mg
- Price
- $414.2
- Updated
- 2025/07/31
5,5'-((1E,1'E)-1,4-phenylenebis(ethene-2,1-diyl))bis(2-hydroxybenzoic acid) Chemical Properties,Usage,Production
Uses
X-34 is a lipophilic and bright yellow-green fluorescent derivative of Congo red (HY-D0236). X-34 can be used to stain neuritic and diffuse plaques, neurofibrillary tangles (NFTs), neuropil threads, and cerebrovascular amyloid in the brain. X-34 can be used for research of Alzheimer’s disease[1].
Biological Activity
Fluorescent, amyloid-specific dye', 'X-34 (1,4-bis(3-carboxy-4-hydroxyphenylethenyl)-benzene) is one among the small-molecule γ-secretase modulators (GSMs) involved in lowering Aβ42 levels (the 42-residue isoform of the amyloid-β peptide). X-34 has also been used to visualize intracellular immunoreactive deposits with classic amyloid fibrillar ultrastructure in living transgenic Caenorhabditis elegans animals. It is also used as a histochemical stain for determining pathological changes in Alzheimerμs disease (AD).', 'X-34 is a fluorescent, amyloid-specific dye. It binds at a different site than Pittsburgh Compound B and is a highly fluorescent marker for beta-sheet structures.
References
[1] Styren SD, et al. X-34, a fluorescent derivative of Congo red: a novel histochemical stain for Alzheimer's disease pathology. J Histochem Cytochem. 2000 Sep;48(9):1223-32. DOI:10.1177/002215540004800906
[2] Link CD, et al. Visualization of fibrillar amyloid deposits in living, transgenic Caenorhabditis elegans animals using the sensitive amyloid dye, X-34. Neurobiol Aging. 2001 Mar-Apr;22(2):217-26. DOI:10.1016/s0197-4580(00)00237-2
5,5'-((1E,1'E)-1,4-phenylenebis(ethene-2,1-diyl))bis(2-hydroxybenzoic acid) Preparation Products And Raw materials
Raw materials
Preparation Products
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