ChemicalBook > CAS DataBase List > 1H-Benzimidazole-6-carboxamide, 2-(2-hydroxyphenyl)-N-(2-propen-1-yloxy)-
1H-Benzimidazole-6-carboxamide, 2-(2-hydroxyphenyl)-N-(2-propen-1-yloxy)-
- Product Name
- 1H-Benzimidazole-6-carboxamide, 2-(2-hydroxyphenyl)-N-(2-propen-1-yloxy)-
- CAS No.
- 2404756-81-4
- Chemical Name
- 1H-Benzimidazole-6-carboxamide, 2-(2-hydroxyphenyl)-N-(2-propen-1-yloxy)-
- Synonyms
- X5050;XX5050;1H-Benzimidazole-6-carboxamide, 2-(2-hydroxyphenyl)-N-(2-propen-1-yloxy)-
- CBNumber
- CB48885069
- Molecular Formula
- C17H15N3O3
- Formula Weight
- 309.32
- MOL File
- 2404756-81-4.mol
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1H-Benzimidazole-6-carboxamide, 2-(2-hydroxyphenyl)-N-(2-propen-1-yloxy)- Property
- Density
- 1.323±0.06 g/cm3(Predicted)
- pka
- 9.11±0.30(Predicted)
- form
- Solid
- color
- White to light yellow
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1H-Benzimidazole-6-carboxamide, 2-(2-hydroxyphenyl)-N-(2-propen-1-yloxy)- Chemical Properties,Usage,Production
Uses
X5050 is a REST inhibitor, with an EC50 of 2.1 μM[1].
in vivo
X5050 (2 x 2μl of 20 mM) is active in HD pathological context[1].
| Animal Model: | 12-week-old male C57Bl6 mice[1].2 |
| Dosage: | 2 x 2μl of 20 mM in 10% DMSO in water. |
| Administration: | Intraventricular injection. |
| Result: | Increased BDNF expression. A decrease in Darpp32 and Snap25 expression was found by QRT-PCR in the lesioned striatum as compared with the contralateral striatum. Significantly increased the levels of Bdnf II splice variant (exon II containing variant) while Bdnf IV levels were not significantly changed. |
References
[1] Jérémie Charbord, et al. High throughput screening for inhibitors of REST in neural derivatives of human embryonic stem cells reveals a chemical compound that promotes expression of neuronal genes. Stem Cells. 2013 Sep;31(9):1816-28. DOI:10.1002/stem.1430
1H-Benzimidazole-6-carboxamide, 2-(2-hydroxyphenyl)-N-(2-propen-1-yloxy)- Preparation Products And Raw materials
Raw materials
Preparation Products
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