4,4’-Difluoro-2,2’-bipyridine

Product Name: 4,4’-Difluoro-2,2’-bipyridine
CAS No.: 1189458-67-0
Chemical Name: 4,4’-Difluoro-2,2’-bipyridine
Synonyms: 4,4’-Difluoro-2,2’-bipyridine;2,2'-Bipyridine, 4,4'-difluoro-
CBNumber: CB33117128
Molecular Formula: C10H6F2N2
Formula Weight: 192.16
MOL File: 1189458-67-0.mol

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4,4’-Difluoro-2,2’-bipyridine Property

Boiling point:: 287.4±35.0 °C(Predicted)
Density: 1.284±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 2.86±0.30(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: HCH0361186
Product name: 4,4'-DIFLUORO-2,2'-BIPYRIDINE
Purity: 95.00%
Packaging: 5MG
Price: $501.25
Updated: 2021/12/16

Ambeed

Product number: A394119
Product name: 4,4'-Difluoro-2,2'-bipyridine
Purity: 97%
Packaging: 50mg
Price: $65
Updated: 2021/12/16

Ambeed

Product number: A394119
Product name: 4,4'-Difluoro-2,2'-bipyridine
Purity: 97%
Packaging: 100mg
Price: $105
Updated: 2021/12/16

Ambeed

Product number: A394119
Product name: 4,4'-Difluoro-2,2'-bipyridine
Purity: 97%
Packaging: 250mg
Price: $198
Updated: 2021/12/16

Ambeed

Product number: A394119
Product name: 4,4'-Difluoro-2,2'-bipyridine
Purity: 97%
Packaging: 1g
Price: $698
Updated: 2021/12/16

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4,4’-Difluoro-2,2’-bipyridine Chemical Properties,Usage,Production

Synthesis

18511-69-8

1189458-67-0

The general procedure for the synthesis of 4,4'-diamino-2,2'-bipyridine from 4,4'-diamino-2,2'-bipyridine was as follows: in a polyethylene reaction vessel, 4,4'-diamino-2,2'-bipyridine (2.00 g, 10.7 mmol), hydrogen fluoride-pyridine complex (65% HF, 31.5 g, 1.02 mol) and toluene ( 30mL). After cooling the mixture to -4°C, sodium nitrite (1.85 g, 26.8 mmol, 2.5 equiv) was added to the reaction vessel. The mouth of the reaction vessel was sealed with polyethylene film and the mixture was stirred at room temperature for 18 hours. Upon completion of the reaction, the pyridine layer was separated by pipette and subsequently alkalized with aqueous sodium hydroxide to pH=10. The alkalized mixture was filtered and the filtrate was extracted with ethyl acetate. The organic layers were combined and dried over anhydrous sodium sulfate. After evaporation of the solvent, the residue was sublimated in vacuo to afford the target product 4,4'-difluoro-2,2'-bipyridine (0.752 g, 36% yield). Product characterization: colorless needle-like crystals. 1H NMR (300MHz, CDCl3) δ 8.64 (dd, J=8.4Hz, 5.4Hz, 2H), 8.18 (dd, J=9.9Hz, 2.4Hz, 2H), 7.08 (dd, J=7.8Hz, 5.4Hz, 2.4Hz, 2H). 19F NMR (283MHz , CDCl3) δ -111.68 to -111.59 (m).

References

[1] Tetrahedron Letters, 2016, vol. 57, # 49, p. 5489 - 5492

4,4’-Difluoro-2,2’-bipyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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1189458-67-0, 4,4’-Difluoro-2,2’-bipyridineRelated Search:

4,4’-Difluoro-2,2’-bipyridine

2,2'-Bipyridine, 4,4'-difluoro-

1189458-67-0