4,4’-Difluoro-2,2’-bipyridine
- Product Name
- 4,4’-Difluoro-2,2’-bipyridine
- CAS No.
- 1189458-67-0
- Chemical Name
- 4,4’-Difluoro-2,2’-bipyridine
- Synonyms
- 4,4’-Difluoro-2,2’-bipyridine;2,2'-Bipyridine, 4,4'-difluoro-
- CBNumber
- CB33117128
- Molecular Formula
- C10H6F2N2
- Formula Weight
- 192.16
- MOL File
- 1189458-67-0.mol
4,4’-Difluoro-2,2’-bipyridine Property
- Boiling point:
- 287.4±35.0 °C(Predicted)
- Density
- 1.284±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 2.86±0.30(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- HCH0361186
- Product name
- 4,4'-DIFLUORO-2,2'-BIPYRIDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.25
- Updated
- 2021/12/16
- Product number
- A394119
- Product name
- 4,4'-Difluoro-2,2'-bipyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $698
- Updated
- 2021/12/16
- Product number
- CM248064
- Product name
- 4,4''-Difluoro-2,2''-bipyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $711
- Updated
- 2021/12/16
- Product number
- 1189458670
- Product name
- 4,4'-Difluoro-2,2'-bipyridine
- Packaging
- 1g
- Price
- $752.4
- Updated
- 2021/12/16
- Product number
- A394119
- Product name
- 4,4'-Difluoro-2,2'-bipyridine
- Purity
- 97%
- Packaging
- 50mg
- Price
- $65
- Updated
- 2021/12/16
4,4’-Difluoro-2,2’-bipyridine Chemical Properties,Usage,Production
Synthesis
18511-69-8
1189458-67-0
The general procedure for the synthesis of 4,4'-diamino-2,2'-bipyridine from 4,4'-diamino-2,2'-bipyridine was as follows: in a polyethylene reaction vessel, 4,4'-diamino-2,2'-bipyridine (2.00 g, 10.7 mmol), hydrogen fluoride-pyridine complex (65% HF, 31.5 g, 1.02 mol) and toluene ( 30mL). After cooling the mixture to -4°C, sodium nitrite (1.85 g, 26.8 mmol, 2.5 equiv) was added to the reaction vessel. The mouth of the reaction vessel was sealed with polyethylene film and the mixture was stirred at room temperature for 18 hours. Upon completion of the reaction, the pyridine layer was separated by pipette and subsequently alkalized with aqueous sodium hydroxide to pH=10. The alkalized mixture was filtered and the filtrate was extracted with ethyl acetate. The organic layers were combined and dried over anhydrous sodium sulfate. After evaporation of the solvent, the residue was sublimated in vacuo to afford the target product 4,4'-difluoro-2,2'-bipyridine (0.752 g, 36% yield). Product characterization: colorless needle-like crystals. 1H NMR (300MHz, CDCl3) δ 8.64 (dd, J=8.4Hz, 5.4Hz, 2H), 8.18 (dd, J=9.9Hz, 2.4Hz, 2H), 7.08 (dd, J=7.8Hz, 5.4Hz, 2.4Hz, 2H). 19F NMR (283MHz , CDCl3) δ -111.68 to -111.59 (m).
References
[1] Tetrahedron Letters, 2016, vol. 57, # 49, p. 5489 - 5492
4,4’-Difluoro-2,2’-bipyridine Preparation Products And Raw materials
Raw materials
Preparation Products
4,4’-Difluoro-2,2’-bipyridine Suppliers
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- Country
- India
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