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3PO

Product Name
3PO
CAS No.
18550-98-6
Chemical Name
3PO
Synonyms
3 PO;3-PO;3PO >=98% (HPLC);inhibitor of glucose metabolism;3PO (inhibitor of glucose metabolism);(E)-3-Pyridin-3-yl-1-pyridin-4-yl-propenone;2-Propen-1-one, 3-(3-pyridinyl)-1-(4-pyridinyl)-, (2E)-
CBNumber
CB33121068
Molecular Formula
C13H10N2O
Formula Weight
210.23
MOL File
18550-98-6.mol
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3PO Property

Boiling point:
387.8±42.0 °C(Predicted)
Density 
1.192±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Soluble in DMSO (up to 15 mg/ml) or in Ethanol (up to 5 mg/ml)
form 
powder
pka
3.49±0.11(Predicted)
color 
white to beige
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1343
Product name
3PO
Purity
≥98% (HPLC)
Packaging
5MG
Price
$74.6
Updated
2023/06/20
Sigma-Aldrich
Product number
SML1343
Product name
3PO
Purity
≥98% (HPLC)
Packaging
25MG
Price
$287
Updated
2023/06/20
Cayman Chemical
Product number
19276
Product name
3PO
Purity
≥98%
Packaging
5mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
19276
Product name
3PO
Purity
≥98%
Packaging
10mg
Price
$54
Updated
2024/03/01
Cayman Chemical
Product number
19276
Product name
3PO
Purity
≥98%
Packaging
25mg
Price
$116
Updated
2024/03/01
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3PO Chemical Properties,Usage,Production

Description

3PO (18550-98-6) is an inhibitor of the metabolic enzyme 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3).? PFKFB3 is constitutively expressed by neoplastic cells and is required for the high glycolytic rate (Warburg Effect) of these cells. 3PO inhibits PFKFB3 (IC50?= 1.4 – 24 μM for various cancer cell lines), suppresses glucose uptake, and lowers intracellular concentrations of Fru-2,6-BP, lactate, ATP, NAD+, and NADH.1? Inhibition of cancer cell metabolism via blocking the action of PFKFB3 has been studied in various models.2-4? Inhibition of PFKFB3 has been shown to induce autophagy as a survival mechanism in cancer cells.5? 3PO has also been used to reduce pathological angiogenesis.6

Definition

ChEBI: 3PO is a member of the class of pyridines that is pyridine substituted by a 3-oxo-3-(pyridin-4-yl)prop-1-en-1-yl group at position 3. An inhibitor of PFKFB3 kinase, an enzyme with a key role in glycolysis. It has a role as an antineoplastic agent, an angiogenesis inhibitor, an autophagy inducer, an apoptosis inducer and an EC 2.7.1.105 (6-phosphofructo-2-kinase) inhibitor. It is a member of pyridines and an enone.

Biochem/physiol Actions

3PO is a potent and selective inhibitor of PFKFB3 (6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase) that reduces glycolytic flux and suppresses glucose uptake. 3PO is selectively cytostatic to transformed cells and suppresses the growth of established tumor in mice.

References

1) Clem?et al.?(2008),?Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth; Mol. Cancer Ther.?7?110 2) Clem?et al.?(2013),?Targeting 6-phosphofructo-2-kinase (PFKFB3) as a therapeutic strategy against cancer; Mol. Cancer Ther.?12?1461 3) Lea?et al.?(2015),?Inhibition of Growth of Bladder Cancer Cells by 3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one in Combination with Other Compounds Affecting Glucose Metabolism; Anticancer Res.?35?5889 4) Lea?et al.?(2016),?Inhibition of Growth by Combined Treatment with Inhibitors of Lactate Dehydrogenase and either Phenformin or Inhibitors of 6-Phosphofructo-2-kinase/Fructose-2,6-bisphosphatae 3; Anticancer Res.?36?1479 5) Klarer?et al.?(2014),?Inhibition of 6-phosphofructo-2-kinase (PFKFB3) induces autophagy as a survival mechanism; Cancer Metab.?2?2 6) Schoors?et al.?(2014),?Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesis; Cell Metab.?19?37

3PO Preparation Products And Raw materials

Raw materials

Preparation Products

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3PO Suppliers

China 61 United States 7 Global 68
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
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60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
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58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
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58
Focus Biomolecules
Tel
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Fax
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Email
sales@focusbiomolecules.com
Country
United States
ProdList
1284
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58
Cayman Chemical Company
Tel
--
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Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
MedChemExpress
Tel
--
Fax
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Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
Axon Medchem LLC
Tel
--
Fax
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Email
info@axonmedchem.com
Country
United States
ProdList
763
Advantage
58

18550-98-6, 3PORelated Search:

Geldanamycin CYCLOPAMINE Imatinib mesylate Vorinostat

  • 3PO (inhibitor of glucose metabolism)
  • (E)-3-Pyridin-3-yl-1-pyridin-4-yl-propenone
  • 3 PO;3-PO
  • 2-Propen-1-one, 3-(3-pyridinyl)-1-(4-pyridinyl)-, (2E)-
  • 3PO >=98% (HPLC)
  • inhibitor of glucose metabolism
  • 18550-98-6