7BIO
- Product Name
- 7BIO
- CAS No.
- 916440-85-2
- Chemical Name
- 7BIO
- Synonyms
- 7BIO;7BIO - CAS 916440-85-2 - Calbiochem;7'-Bromo-3-(hydroxyimino)-[2,3'-biindolinylidene]-2'-one;7'-Bromo-3-(hydroxyimino)-[2,3'-biindolinylidene]-2'-one;2H-Indol-2-one, 7-bromo-3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-;tau hyper-phosphorylation,7BIO,cognitive impairment,GSK3β,Cyclin dependent kinase,GSK-3,synaptic impairments,CDK,Inhibitor,CDK5,inhibit,activation of astrocytes and microglia,Glycogen synthase kinase 3,Aβ oligomer,neuroinflammation,Glycogen synthase kinase-3
- CBNumber
- CB33136738
- Molecular Formula
- C16H10BrN3O2
- Formula Weight
- 356.17
- MOL File
- 916440-85-2.mol
7BIO Property
- storage temp.
- +2C to +8C
- solubility
- Soluble in ethanol;DMSO
- form
- Deep black-red solid
- color
- Dark red
N-Bromosuccinimide Price
- Product number
- 19619
- Product name
- 7BIO
- Purity
- ≥99%
- Packaging
- 10mg
- Price
- $157
- Updated
- 2024/03/01
- Product number
- 19619
- Product name
- 7BIO
- Purity
- ≥99%
- Packaging
- 50mg
- Price
- $623
- Updated
- 2024/03/01
- Product number
- B591703
- Product name
- 7BIO
- Packaging
- 25mg
- Price
- $420
- Updated
- 2021/12/16
- Product number
- KIN0008614
- Product name
- 7BIO
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.03
- Updated
- 2021/12/16
- Product number
- AG-MR-C0020-M050
- Product name
- 7BIO
- Purity
- ≥99%(NMR)
- Packaging
- 50mg
- Price
- $520
- Updated
- 2021/12/16
7BIO Chemical Properties,Usage,Production
Description
7BIO is a derivative of indirubin that triggers a rapid cell death process that is distinct from apoptosis and devoid of cytochrome c release or caspase activation. Furthermore, in contrast to other indirubin derivatives, 7BIO has only marginal activity against the classic indirubin targets, cyclin-dependent kinases and GSK3. Instead, 7BIO inhibits FLT3 (IC50 = 0.34 μM) and the dual-specificity tyrosine phosphorylation-regulated kinases, DYRK1A and DYRK2 (IC50s = 1.9 and 1.3 μM, respectively). It also inhibits Aurora B and C kinases with IC50 values of 4.6 and 0.7 μM, respectively.
Uses
7BIO is a caspase independent nonapoptotic cell death inducer.
storage
+4°C
References
[1] ribas j, bettayeb k, ferandin y, et al. 7-bromoindirubin-3′-oxime induces caspase-independent cell death[j]. oncogene, 2006, 25(47): 6304-6318.
[2] myrianthopoulos v, kritsanida m, gaboriaud-kolar n, et al. novel inverse binding mode of indirubin derivatives yields improved selectivity for dyrk kinases[j]. acs medicinal chemistry letters, 2012, 4(1): 22-26.
[3] myrianthopoulos v, magiatis p, ferandin y, et al. an integrated computational approach to the phenomenon of potent and selective inhibition of aurora kinases b and c by a series of 7-substituted indirubins[j]. journal of medicinal chemistry, 2007, 50(17): 4027-4037.
7BIO Preparation Products And Raw materials
Raw materials
Preparation Products
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