HUMAN MDC (CCL22)
Description Source Background- Product Name
- HUMAN MDC (CCL22)
- Chemical Name
- HUMAN MDC (CCL22)
- Synonyms
- CC;MDC;CKR-1;CXCR1;CCL22;STCP-1;CMKAR1;ABCD-1;SCYA22;MIP1aR
- CBNumber
- CB3314140
- Formula Weight
- 0
- MOL File
- Mol file
HUMAN MDC (CCL22) Property
- storage temp.
- −20°C
- form
- lyophilized powder
Safety
- Hazard Codes
- T
- Risk Statements
- 23/24/25-36/37/38
- Safety Statements
- 26-36/37/39-45
N-Bromosuccinimide Price
- Product number
- SRP3111
- Product name
- MDC (67 aa) (CCL22) human
- Purity
- recombinant, expressed in <I>E. coli</I>, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
- Packaging
- 20 μg
- Price
- $356
- Updated
- 2025/07/31
- Product number
- SAB1304942
- Product name
- ANTI-ADAM11 (N-TERM) antibody produced in rabbit
- Purity
- IgG fraction of antiserum, buffered aqueous solution
- Packaging
- 400μL
- Price
- $461
- Updated
- 2023/01/07
- Product number
- 026617
- Product name
- Macrophage Derived Chemokine
- Packaging
- 96Tests
- Price
- $706
- Updated
- 2021/12/16
- Product number
- 472550
- Product name
- MDC
- Packaging
- 96Tests
- Price
- $731
- Updated
- 2021/12/16
- Product number
- M2775
- Product name
- MDC
- Packaging
- 5ug
- Price
- $269
- Updated
- 2021/12/16
HUMAN MDC (CCL22) Chemical Properties,Usage,Production
Description
MDC Human Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 69 amino acids and having a molecular mass of 8.1 kDa.
The MDC is purified by proprietary chromatographic techniques.
Source
Escherichia Coli
Background
MDC (CCL22) is a small cytokine that belongs to the CC chemokine family. CCL22 is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16.
MDC shows chemotactic activity for natural killer cells, chronically activated T lymphocytes, monocytes and dendritic cells. On the other hand, MDC shows a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. MDC may also have a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology. MDC interacts with cell surface chemokine receptors CCR4.
CCL22 is vastly expressed in macrophage and in monocyte-derived dendritic cells, and thymus. CCL22 is also found in the lymph node, appendix, activated monocytes, resting and activated macrophages. Lower expression of CCL22 can be seen in the lung and the spleen and very weak expression in the small intestine. In the lymph node CCL22 is expressed in a mature subset of Langerhans' cells (CD1a+ and CD83+).
Furthermore, CCL22 is expressed in atopic dermatitis, allergic contact dermatitis skin, and psoriasis, in both the epidermis and dermis. In addition, MDC has a role in hindering progression of lung cancer. Moreover, significantly higher CCL22 expression is linked to gastric cancer.
HUMAN MDC (CCL22) Preparation Products And Raw materials
Raw materials
Preparation Products
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