BAY 58-2667 hydrochloride

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BAY 58-2667 hydrochloride

Product Name: BAY 58-2667 hydrochloride
CAS No.: 646995-35-9
Chemical Name: BAY 58-2667 hydrochloride
Synonyms: Cinaciguat HCl;Cinaciguat (hydrochloride);Cinaciguat hydrochloride >=98% (HPLC);BAY 58-2667 hydrochloride - Cinaciguat hydrochloride;4-[[(4-Carboxybutyl)[2-[2-[[4-(2-phenylethyl)phenyl]methoxy]phenyl]ethyl]amino]methyl]benzoic acid hydrochloride
CBNumber: CB33146261
Molecular Formula: C36H40ClNO5
Formula Weight: 602.17
MOL File: 646995-35-9.mol

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BAY 58-2667 hydrochloride Property

storage temp.: -20°C
solubility: DMSO:66.74(Max Conc. mg/mL);110.83(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);0.83(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);49.82(Max Conc. mM)
Ethanol:5.0(Max Conc. mg/mL);8.3(Max Conc. mM)
form: powder
color: white to beige

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1532
Product name: Cinaciguat hydrochloride
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $238
Updated: 2023/06/20

Sigma-Aldrich

Product number: SML1532
Product name: Cinaciguat hydrochloride
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $953
Updated: 2023/06/20

Cayman Chemical

Product number: 17468
Product name: Cinaciguat (hydrochloride)
Purity: ≥98%
Packaging: 500μg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 17468
Product name: Cinaciguat (hydrochloride)
Purity: ≥98%
Packaging: 1mg
Price: $100
Updated: 2024/03/01

Cayman Chemical

Product number: 17468
Product name: Cinaciguat (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $384
Updated: 2024/03/01

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BAY 58-2667 hydrochloride Chemical Properties,Usage,Production

Uses

Cinaciguat hydrochloride is a potent soluble guanylate cyclase (GC) activator with EC50 of 15 nM in platelets.

Biochem/physiol Actions

Cinaciguat activates sGC (soluble guanylate cyclase) independently of NO. Cinaciguat binds to sGC′s NO-sensory H-NOX domain when it is heme-depleted. Also, the compound Cinaciguat protects sGC from oxidation-induced ubiquitin-triggered degradation.

in vivo

Administration of Cinaciguat decreased BP and increased HR in both apo-sGC mice and WT mice. In fact, the BP-lowering effect of Cinaciguat in apo-sGC mice is significantly greater and longer lasting than in WT mice. In addition, Cinaciguat decreased BP in apo-sGC mice at concentrations that did not affect BP in WT mice. Furthermore, the IC₅₀ values for Cinaciguat-induced ex vivorelaxation of precontracted aortas are threefold lower in apo-sGC mice than in WT mice (IC₅₀=0.2 nM and 0.7 nM, respectively). Together, our results suggest that sGC activators like Cinaciguat but not sGC stimulators like BAY 41-2272 activate apo-sGC. In addition, the observation that Cinaciguat can modulate vasorelaxation and BP in WT mice suggests that even in healthy mice, a subset of the available sGC pool is haem-free and responsive to sGC activators^[2].

storage

Store at -20°C

References

[1] Roy B, et al. Probing the presence of the ligand-binding haem in cellular nitric oxide receptors. Br J Pharmacol. 2008 Apr;153(7):1495-504. DOI:10.1038/sj.bjp.0707687
[2] Thoonen R, et al. Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice. Nat Commun. 2015 Oct 7;6:8482. DOI:10.1038/ncomms9482

BAY 58-2667 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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646995-35-9, BAY 58-2667 hydrochlorideRelated Search:

Cinaciguat (hydrochloride)

Cinaciguat HCl

4-[[(4-Carboxybutyl)[2-[2-[[4-(2-phenylethyl)phenyl]methoxy]phenyl]ethyl]amino]methyl]benzoic acid hydrochloride

BAY 58-2667 hydrochloride - Cinaciguat hydrochloride

Cinaciguat hydrochloride >=98% (HPLC)

646995-35-9

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