BAY 58-2667 hydrochloride
- Product Name
- BAY 58-2667 hydrochloride
- CAS No.
- 646995-35-9
- Chemical Name
- BAY 58-2667 hydrochloride
- Synonyms
- Cinaciguat HCl;Cinaciguat (hydrochloride);Cinaciguat hydrochloride >=98% (HPLC);BAY 58-2667 hydrochloride - Cinaciguat hydrochloride;4-[[(4-Carboxybutyl)[2-[2-[[4-(2-phenylethyl)phenyl]methoxy]phenyl]ethyl]amino]methyl]benzoic acid hydrochloride
- CBNumber
- CB33146261
- Molecular Formula
- C36H40ClNO5
- Formula Weight
- 602.17
- MOL File
- 646995-35-9.mol
BAY 58-2667 hydrochloride Property
- storage temp.
- -20°C
- solubility
- DMSO:66.74(Max Conc. mg/mL);110.83(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);0.83(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);49.82(Max Conc. mM)
Ethanol:5.0(Max Conc. mg/mL);8.3(Max Conc. mM) - form
- powder
- color
- white to beige
N-Bromosuccinimide Price
- Product number
- SML1532
- Product name
- Cinaciguat hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $238
- Updated
- 2023/06/20
- Product number
- SML1532
- Product name
- Cinaciguat hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $953
- Updated
- 2023/06/20
- Product number
- 17468
- Product name
- Cinaciguat (hydrochloride)
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 17468
- Product name
- Cinaciguat (hydrochloride)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $100
- Updated
- 2024/03/01
- Product number
- 17468
- Product name
- Cinaciguat (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $384
- Updated
- 2024/03/01
BAY 58-2667 hydrochloride Chemical Properties,Usage,Production
Uses
Cinaciguat hydrochloride is a potent soluble guanylate cyclase (GC) activator with EC50 of 15 nM in platelets.
Biochem/physiol Actions
Cinaciguat activates sGC (soluble guanylate cyclase) independently of NO. Cinaciguat binds to sGC′s NO-sensory H-NOX domain when it is heme-depleted. Also, the compound Cinaciguat protects sGC from oxidation-induced ubiquitin-triggered degradation.
in vivo
Administration of Cinaciguat decreased BP and increased HR in both apo-sGC mice and WT mice. In fact, the BP-lowering effect of Cinaciguat in apo-sGC mice is significantly greater and longer lasting than in WT mice. In addition, Cinaciguat decreased BP in apo-sGC mice at concentrations that did not affect BP in WT mice. Furthermore, the IC50 values for Cinaciguat-induced ex vivorelaxation of precontracted aortas are threefold lower in apo-sGC mice than in WT mice (IC50=0.2 nM and 0.7 nM, respectively). Together, our results suggest that sGC activators like Cinaciguat but not sGC stimulators like BAY 41-2272 activate apo-sGC. In addition, the observation that Cinaciguat can modulate vasorelaxation and BP in WT mice suggests that even in healthy mice, a subset of the available sGC pool is haem-free and responsive to sGC activators[2].
storage
Store at -20°C
References
[1] Roy B, et al. Probing the presence of the ligand-binding haem in cellular nitric oxide receptors. Br J Pharmacol. 2008 Apr;153(7):1495-504. DOI:10.1038/sj.bjp.0707687
[2] Thoonen R, et al. Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice. Nat Commun. 2015 Oct 7;6:8482. DOI:10.1038/ncomms9482