KRIBB11
- Product Name
- KRIBB11
- CAS No.
- 342639-96-7
- Chemical Name
- KRIBB11
- Synonyms
- CS-2403;KRIBB11;KRIBB 11;KRIBB-11;KRIBB11, 10 mM in DMSO;N2-1H-Indazol-5-yl-N6-methyl-3-nitro-2,6-pyridinediamine;N2-(1H-Indazol-5-yl)-N6-methyl-3-nitropyridine-2,6-diamine;2,6-Pyridinediamine, N2-1H-indazol-5-yl-N6-methyl-3-nitro-;KRIBB11,KRIBB 11,HSP,Apoptosis,Inhibitor,inhibit,Heat shock proteins,KRIBB-11
- CBNumber
- CB33146317
- Molecular Formula
- C13H12N6O2
- Formula Weight
- 284.27
- MOL File
- 342639-96-7.mol
KRIBB11 Property
- Boiling point:
- 534.9±50.0 °C(Predicted)
- Density
- 1.531±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO:27.0(Max Conc. mg/mL);94.98(Max Conc. mM)
- form
- powder
- pka
- 13.59±0.40(Predicted)
- color
- yellow to orange
N-Bromosuccinimide Price
- Product number
- SML1412
- Product name
- KRIBB11 trifluoroacetate salt
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $87.6
- Updated
- 2025/07/31
- Product number
- SML1412
- Product name
- KRIBB11 trifluoroacetate salt
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $268
- Updated
- 2025/07/31
- Product number
- 385570
- Product name
- Heat Shock Factor 1 Inhibitor, KRIBB11
- Purity
- The Heat Shock Factor 1 Inhibitor, KRIBB11 controls the biological activity of Heat Shock Factor 1.
- Packaging
- 10 mg
- Price
- $126
- Updated
- 2025/07/31
- Product number
- 9002528
- Product name
- KRIBB11
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 9002528
- Product name
- KRIBB11
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $115
- Updated
- 2024/03/01
KRIBB11 Chemical Properties,Usage,Production
Uses
KRIBB 11 is a heat shock factor (HSF) inhibitor that induces apoptosis in cancer cells. KRIBB 11 exhibits anticancer properties.
Biological Activity
KRIBB11 is an inhibitor of the transcription factor He at Shock Factor 1 (HSF1) with an IC50 value of 1.2 μM. KRIBB11 blocks induction of HSF1 downstream target proteins such as HSP27 and HSP70 by impairing the recruitment of Positive Transcription Elongation Factor b (P-TEFb) to the HSF1 transcriptional complex, preventing HSF1-mediated gene expression KRIBB11 inhibits tumor growth in vivo and acts synergistically to increase apoptosis in cancer cells treated with the HSP90 inhibitors Geldanamycin and 17-AAG.', 'KRIBB11 is capable of preventing the proliferation of cancer cells. It has the ability to stimulate apoptosis and can arrest the cell cycle at G2/M phase.
Synthesis
342639-94-5
74-89-5
342639-96-7
Example 3 Preparation of N2-(1H-indazol-5-yl)-N6-methyl-3-nitropyridine-2,6-diamine To a reaction flask containing methanol with 40% aqueous methylamine (20 mL) was added 2-(1H-indazol-5-ylamino)-6-methoxy-3-nitropyridine (1 g) obtained by Example 1. The reaction mixture was stirred at 25°C for 1 hour. Subsequently, deionized water (20 mL) was slowly added to the reaction mixture and stirring was continued for 1 hour. After completion of the reaction, the reaction mixture was filtered and the solid product was washed with 30% aqueous methanol (5 mL). The resulting solid product was dried under vacuum at 50-60 °C to afford the target compound N2-(1H-indazol-5-yl)-N6-methyl-3-nitropyridine-2,6-diamine (0.82 g, 82% yield). Melting point: 238-240 °C. 1H-NMR (DMSO-d6, δ, ppm): 2.86 (d, 3H), 6.09 (d, 1H), 7.51 (d, 1H), 7.57 (d, 1H), 8.05 (t, 2H), 8.24 (d, 2H), 10.97 (s, 1H), 13.05 (br s, 1H).
storage
Store at -20°C
References
[1] Patent: US6743795, 2004, B1. Location in patent: Page/Page column 8
KRIBB11 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from KRIBB11 manufacturers
- Product
- KRIBB11 342639-96-7
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 20kg
- Release date
- 2019-12-23