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phenyl (4-((6-carbamoyl-7-methoxyquinolin-4-yl)oxy)-2-chlorophenyl)carbamate

Product Name
phenyl (4-((6-carbamoyl-7-methoxyquinolin-4-yl)oxy)-2-chlorophenyl)carbamate
CAS No.
417722-95-3
Chemical Name
phenyl (4-((6-carbamoyl-7-methoxyquinolin-4-yl)oxy)-2-chlorophenyl)carbamate
Synonyms
Lenvatinib Impurity 58;LenvatinibImpurity12HCl;Lenvatinib Intermediates 2;Phenyloxy Descyclopropylamino Lenvatinib;Phenyl N-(4-(6-carbamoyl-7-methoxy-4-quinolyl)oxy-2-chlorophenyl)carbamate;phenyl (4-((6-carbamoyl-7-methoxyquinolin-4-yl)oxy)-2-chlorophenyl)carbamate;Phenyl N-[4-[[6-(aminocarbonyl)-7-methoxy-4-quinolinyl]oxy]-2-chlorophenyl]carbamate;Carbamic acid,[4-[[6-(aminocarbonyl)-7-methoxy-4-quinolinyl]oxy]-2-chlorophenyl]-,phenyl ester;CARBAMIC ACID,[4-[[6-(AMINOCARBONYL)-7-METHOXY-4-QUINOLINYL]OXY]-2-CHLOROPHENYL]-,PHENYL ESTER;;Carbamic acid, N-[4-[[6-(aminocarbonyl)-7-methoxy-4-quinolinyl]oxy]-2-chlorophenyl]-, phenyl ester
CBNumber
CB33147460
Molecular Formula
C24H18ClN3O5
Formula Weight
463.87
MOL File
417722-95-3.mol
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phenyl (4-((6-carbamoyl-7-methoxyquinolin-4-yl)oxy)-2-chlorophenyl)carbamate Property

Boiling point:
644.8±55.0 °C(Predicted)
Density 
1.418±0.06 g/cm3(Predicted)
pka
11.16±0.70(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H319Causes serious eye irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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phenyl (4-((6-carbamoyl-7-methoxyquinolin-4-yl)oxy)-2-chlorophenyl)carbamate Chemical Properties,Usage,Production

Uses

Phenyloxy Descyclopropylamino Lenvatinib is an intermediate in the synthesis of Descyclopropyl Lenvatinib (D288150), a metabolite of Lenvatinib (L329400) which is an orally active inhibitor of multiple receptor tyrosine kinases including VEGF, FGF and SCF receptors.

phenyl (4-((6-carbamoyl-7-methoxyquinolin-4-yl)oxy)-2-chlorophenyl)carbamate Preparation Products And Raw materials

Raw materials

Preparation Products

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phenyl (4-((6-carbamoyl-7-methoxyquinolin-4-yl)oxy)-2-chlorophenyl)carbamate Suppliers

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417722-95-3, phenyl (4-((6-carbamoyl-7-methoxyquinolin-4-yl)oxy)-2-chlorophenyl)carbamateRelated Search:

Lenvatinib Impurity P 1-(2-chloro-4-hydroxyphenyl)-3-cyclopropylurea Lenvatinib Impurity 8 Lenvatinib Impurity f 6-Quinolinecarboxylic acid, 4-(4-amino-3-chlorophenoxy)-7-methoxy-, methyl ester Lenvatinib Impurity 5 Lenvatinib Impurity O 6-Quinolinecarboxamide, 4-[3-chloro-4-[[(ethylamino)carbonyl]amino]phenoxy]-7-methoxy- 6-Quinolinecarboxamide, 4-[(2-chloro-4-hydroxyphenyl)amino]-7-methoxy- 6-Quinolinecarboxamide, 4-hydroxy-7-methoxy- Descyclopropyl Lenvatinib 4-(4-amino-3-chlorophenoxy)-7-methoxyquinoline-6-carboxamide 4,4'-[Carbonylbis[imino(3-chloro-4,1-phenylene)oxy]]bis[7-methoxy-6-quinolinecarboxamide] Lenvatinib Impurity 2 Lenvatinib Impurity d 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxaMide 4-chloro-7-Methoxyquinoline-6-carboxaMide Lenvatinib Impurity 12

  • phenyl (4-((6-carbamoyl-7-methoxyquinolin-4-yl)oxy)-2-chlorophenyl)carbamate
  • Phenyl N-(4-(6-carbamoyl-7-methoxy-4-quinolyl)oxy-2-chlorophenyl)carbamate
  • Carbamic acid,[4-[[6-(aminocarbonyl)-7-methoxy-4-quinolinyl]oxy]-2-chlorophenyl]-,phenyl ester
  • CARBAMIC ACID,[4-[[6-(AMINOCARBONYL)-7-METHOXY-4-QUINOLINYL]OXY]-2-CHLOROPHENYL]-,PHENYL ESTER;
  • Lenvatinib Intermediates 2
  • Carbamic acid, N-[4-[[6-(aminocarbonyl)-7-methoxy-4-quinolinyl]oxy]-2-chlorophenyl]-, phenyl ester
  • Phenyloxy Descyclopropylamino Lenvatinib
  • Lenvatinib Impurity 14Q: What is Lenvatinib Impurity 14 Q: What is the CAS Number of Lenvatinib Impurity 14
  • LenvatinibImpurity12HCl
  • Phenyl N-[4-[[6-(aminocarbonyl)-7-methoxy-4-quinolinyl]oxy]-2-chlorophenyl]carbamate
  • Lenvatinib Impurity 58
  • 417722-95-3