GNE-140 (racemate)

Product Name: GNE-140 (racemate)
CAS No.: 1802977-61-2
Chemical Name: GNE-140 (racemate)
Synonyms: GNE-140 (racemate);GNE-140 racemate (GNE 140 racemate;3-((2-chlorophenyl)thio)-6-(4-morpholinophenyl)-6-(thiophen-3-yl)piperidine-2,4-dione;2,4-Piperidinedione, 3-[(2-chlorophenyl)thio]-6-[4-(4-morpholinyl)phenyl]-6-(3-thienyl)-
CBNumber: CB33152079
Molecular Formula: C25H23ClN2O3S2
Formula Weight: 499.04
MOL File: 1802977-61-2.mol

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GNE-140 (racemate) Property

Boiling point:: 739.0±60.0 °C(Predicted)
Density: 1.43±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO : ≥ 34 mg/mL (68.13 mM)
pka: 9.61±0.70(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-5958
Product name: GNE-140(racemate)
Purity: 99.66%
Packaging: 1mg
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-5958
Product name: GNE-140(racemate)
Purity: 99.66%
Packaging: 5mg
Price: $220
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BG166816
Product name: GNE 140
Packaging: 10mg
Price: $225
Updated: 2021/12/16

AK Scientific

Product number: 2927EF
Product name: GNE-140(racemate)
Packaging: 10mg
Price: $353
Updated: 2021/12/16

ChemScene

Product number: CS-5958
Product name: GNE-140(racemate)
Purity: 99.66%
Packaging: 10mg
Price: $370
Updated: 2021/12/16

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GNE-140 (racemate) Chemical Properties,Usage,Production

Description

GNE-140 racemate is a racemate mixture of (R)-GNE-140 and (S)-GNE-140. GNE-140 racemate is a potent lactate dehydrogenase A (LDHA) inhibitor

Uses

GNE-140 racemate is a racemate mixture of (R)-GNE-140 and (S)-GNE-140. GNE-140 racemate is a potent lactate dehydrogenase A (LDHA) inhibitor[1][2].

in vitro

Increased glucose consumption distinguishes cancer cells from normal cells and is known as the “Warburg effect” because of increased glycolysis. Lactate dehydrogenase A (LDHA) is a key glycolytic enzyme, a hallmark of aggressive cancers, and believed to be the major enzyme responsible for pyruvate-to-lactate conversion.

References

[1] dralevi M, et al. Double genetic disruption of lactate dehydrogenases A and B is required to ablate the "Warburg effect" restricting tumor growth to oxidative metabolism. J Biol Chem. 2018 Oct 12;293(41):15947-15961. DOI:10.1074/jbc.RA118.004180
[2] Purkey HE, et al. Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice. ACS Med Chem Lett. 2016 Aug 26;7(10):896-901. DOI:10.1021/acsmedchemlett.6b00190

GNE-140 (racemate) Preparation Products And Raw materials

Raw materials

Preparation Products

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GNE-140 (racemate) Suppliers

China 48 United States 3 Global 51

Shanghai Lollane Biological Technology Co.,Ltd.

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1802977-61-2, GNE-140 (racemate)Related Search:

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GNE-140 racemate (GNE 140 racemate

GNE-140 (racemate)

3-((2-chlorophenyl)thio)-6-(4-morpholinophenyl)-6-(thiophen-3-yl)piperidine-2,4-dione

2,4-Piperidinedione, 3-[(2-chlorophenyl)thio]-6-[4-(4-morpholinyl)phenyl]-6-(3-thienyl)-

1802977-61-2