CRANAD 28
- Product Name
- CRANAD 28
- CAS No.
- 1623747-97-6
- Chemical Name
- CRANAD 28
- Synonyms
- CRANAD 28;CRANAD-28,beta plaques,Inhibitor,CRANAD 28,inhibit;1,7-Bis(5-methyl-1-phenyl-1H-pyrazol-4-yl)hepta-1,6-diene-3,5-dione-difluoroboron;4,4'-((1E,1'E)-(2,2-difluoro-2H-1l3,3,2l4-dioxaborinine-4,6-diyl)bis(ethene-2,1-diyl))bis(5-methyl-1-phenyl-1H-pyrazole);4,4'-((1E,1'E)-(2,2-difluoro-2H-1l3,3,2l4-dioxaborinine-4,6-diyl)bis(ethene-2,1-diyl))bis(5-methyl-1-phenyl-1H-pyrazole);4-[(E)-2-[2,2-difluoro-6-[2-(5-methyl-1-phenylpyrazol-1-ium-4-ylidene)ethylidene]-1,3-dioxa-2-boranuidacyclohex-4-en-4-yl]ethenyl]-5-methyl-1-phenylpyrazole
- CBNumber
- CB33152594
- Molecular Formula
- C27H23BF2N4O2
- Formula Weight
- 484.3049264
- MOL File
- 1623747-97-6.mol
CRANAD 28 Property
- storage temp.
- Store at -20°C
- solubility
- DMF: 2 mg/ml; DMSO: 2 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
- form
- A crystalline solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 19816
- Product name
- CRANAD 28
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 19816
- Product name
- CRANAD 28
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $61
- Updated
- 2024/03/01
- Product number
- 19816
- Product name
- CRANAD 28
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $243
- Updated
- 2024/03/01
- Product number
- 19816
- Product name
- CRANAD 28
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $426
- Updated
- 2024/03/01
- Product number
- SYN5491
- Product name
- CRANAD-28
- Packaging
- 50mg
- Price
- $1268
- Updated
- 2021/12/16
CRANAD 28 Chemical Properties,Usage,Production
Description
CRANAD 28 is a curcumin derivative and non-conjugated fluorescent affinity probe for the detection of amyloid-β (Aβ) in vitro and in vivo that has excitation/emission spectra of 498/578 nm, respectively. It binds to various forms of Aβ, including Aβ40 monomers and aggregates, as well as Aβ42 monomers, dimers, and oligomers (Kds = 68.8, 52.4, 159.7, 162.9, and 85.7 nM, respectively). When bound to Aβ, the fluorescence intensity decreases, in contrast to similar curcumin-based fluorescent probes. CRANAD 28 labels amyloid plaques and cerebral amyloid angiopathy both in APP/PS1 mouse brain sections and in live mice following i.v. administration. It also inhibits copper-induced and naturally occurring Aβ crosslinking.
CRANAD 28 Preparation Products And Raw materials
Raw materials
Preparation Products
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