ChemicalBook > CAS DataBase List > PKCε Inhibitor Peptide
PKCε Inhibitor Peptide
- Product Name
- PKCε Inhibitor Peptide
- CAS No.
- 182683-50-7
- Chemical Name
- PKCε Inhibitor Peptide
- Synonyms
- ε-V1-2;epsilonV1-2;KNTBAGOTDJPUJV-XMTFRXHISA-N;L-a-Glutamyl-L-alanyl-L-valyl-L-seryl-L-leucyl-L-lysyl-L-prolyl-L-threonine;L-α-Glutamyl-L-alanyl-L-valyl-L-seryl-L-leucyl-L-lysyl-L-prolyl-L-threonine;L-Threonine, L-α-glutamyl-L-alanyl-L-valyl-L-seryl-L-leucyl-L-lysyl-L-prolyl-
- CBNumber
- CB33152716
- Molecular Formula
- C37H65N9O13
- Formula Weight
- 843.96
- MOL File
- 182683-50-7.mol
More
Less
PKCε Inhibitor Peptide Property
- Boiling point:
- 1280.1±65.0 °C(Predicted)
- Density
- 1.288±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 10 mg/ml; PBS (pH 7.2): 5 mg/ml
- form
- A crystalline solid
- pka
- 3.28±0.10(Predicted)
- color
- White to off-white
More
Less
N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 17476
- Product name
- PKCε Inhibitor Peptide
- Purity
- ≥95%
- Packaging
- 500μg
- Price
- $32
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 17476
- Product name
- PKCε Inhibitor Peptide
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $50
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 17476
- Product name
- PKCε Inhibitor Peptide
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $230
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 17476
- Product name
- PKCε Inhibitor Peptide
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $426
- Updated
- 2024/03/01
TRC
- Product number
- G596920
- Product name
- L-α-Glutamyl-L-alanyl-L-valyl-L-seryl-L-leucyl-L-lysyl-L-prolyl-L-threonine
- Packaging
- 5mg
- Price
- $195
- Updated
- 2021/12/16
More
Less
PKCε Inhibitor Peptide Chemical Properties,Usage,Production
Uses
L-α-Glutamyl-L-alanyl-L-valyl-L-seryl-L-leucyl-L-lysyl-L-prolyl-L-threonine selectively and reversibly inhibits the translocation of PKC? to intracellular membranes, blocking activation. It is a calcium-independent, phospholipid- and diacylglycerol-dependent serine/threonine kinase.
in vivo
Epsilon-V1-2 (20 mg/kg/day; osmotic pumps; daily; for 4 weeks) treatment significantly improves the beating score in a murine heterotopic transplantation model. Epsilon-V1-2 reduces infiltration of macrophages and T cells into the cardiac grafts, and decreases parenchymal fibrosis. Epsilon-V1-2 treatment almost abolishes the rise in pro-fibrotic cytokine, TGF-β and monocyte recruiting chemokine MCP-1 levels[3].
| Animal Model: | C57BL/6J mice transplanted the hearts of FVB mice[3] |
| Dosage: | 20 mg/kg/day |
| Administration: | 0.1 mL osmotic pumps implanted subcutaneously; daily; for 4 weeks |
| Result: | Significantly improved the beating score throughout the treatment. |
IC 50
PKCε
PKCε Inhibitor Peptide Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
PKCε Inhibitor Peptide Suppliers
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9803
- Advantage
- 58
- Tel
- 021-QQ：65489617 15618227136
- Fax
- 21-5161 9052
- Sales@ATKchemical.com
- Country
- China
- ProdList
- 9125
- Advantage
- 58
- Tel
- 010-50973130 18101056239
- 3193328036@qq.com
- Country
- China
- ProdList
- 29760
- Advantage
- 68
- Tel
- +86-17380623303
- Fax
- 028-62328193
- Caroline@youngshechem.com
- Country
- China
- ProdList
- 4802
- Advantage
- 58
- Tel
- 0571-87213919
- Eric@peptidego.com
- Country
- China
- ProdList
- 7408
- Advantage
- 58
- Tel
- 400-9205774
- sales@glpbio.cn
- Country
- China
- ProdList
- 6777
- Advantage
- 58
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58
- Tel
- +1-2135480471
- sales@sarms4muscle.com
- Country
- China
- ProdList
- 10473
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11218
- Advantage
- 58
- Tel
- 0510-85629785 18013409632
- Fax
- 0510-85625359
- sales@reading-chemicals.com
- Country
- China
- ProdList
- 14081
- Advantage
- 58