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(S)-CR8

Product Name
(S)-CR8
CAS No.
1084893-56-0
Chemical Name
(S)-CR8
Synonyms
CR8, (S)-Isomer;(S)-CR8, CDK 1, 2, 5, 7 and 9 inhibitor;CR8, (S)-Isomer - CAS 1084893-56-0 - Calbiochem;1-Butanol, 2-[[9-(1-methylethyl)-6-[[[4-(2-pyridinyl)phenyl]methyl]amino]-9H-purin-2-yl]amino]-, (2S)-
CBNumber
CB33152923
Molecular Formula
C24H29N7O
Formula Weight
431.53
MOL File
1084893-56-0.mol
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(S)-CR8 Property

Boiling point:
671.4±65.0 °C(Predicted)
Density 
1.27±0.1 g/cm3(Predicted)
storage temp. 
+2C to +8C
solubility 
DMSO: soluble,Ethanol: soluble
form 
Off-white solid
pka
14.56±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
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N-Bromosuccinimide Price

Cayman Chemical
Product number
29985
Product name
(S)-CR8
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
29985
Product name
(S)-CR8
Packaging
25mg
Price
$479
Updated
2024/03/01
Cayman Chemical
Product number
29985
Product name
(S)-CR8
Packaging
5mg
Price
$183
Updated
2024/03/01
Cayman Chemical
Product number
29985
Product name
(S)-CR8
Packaging
10mg
Price
$278
Updated
2024/03/01
Adipogen Life Sciences
Product number
AG-MR-C0004-M010
Product name
(S)-CR8
Purity
≥99%(NMR)
Packaging
10mg
Price
$200
Updated
2021/12/16
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(S)-CR8 Chemical Properties,Usage,Production

Description

(S)-CR8 is a second generation derivative of (R)-roscovitine and an inhibitor of cyclin-dependent kinase 1 (Cdk1/cyclin B), Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25, and Cdk9/cyclin T (IC50s = 0.15, 0.08, 0.06, 0.12, and 0.11 μM, respectively). It also inhibits casein kinase CK1δ/ε (CKδ/ε) and DYRK1A (IC50s = 0.61 and 0.9 μM, respectively). (S)-CR8 reduces cell viability in human neuroblastoma cell lines, including SH-SY5Y, SK-N-AS, SK-N-BE, and IMR32 cells (IC50s = 0.43, 1.46, 0.13, and 0.14 μM, respectively). It also reduces protein levels of the survival factor Mcl-1 in SH-SY5Y cells.

Definition

ChEBI: (2S)-2-[[9-propan-2-yl-6-[[4-(2-pyridinyl)phenyl]methylamino]-2-purinyl]amino]-1-butanol is a phenylpyridine.

(S)-CR8 Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-CR8 Suppliers

China 10 United States 5 Global 15
Hubei Chuangliankangcheng Pharmaceutical Co., Ltd.
Tel
027-65388397 18164111589
Fax
027-65388397
Email
3321478047@qq.com
Country
China
ProdList
1995
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
7295
Advantage
58
Shanghai SuperLan Chemcial Technique Centre
Tel
021-2022843681 15618226720
Fax
+86-21-51601218
Email
lucy@atkchemical.com
Country
China
ProdList
9952
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Suzhou Chenrui Biotechnology Co. LTD
Tel
17625585511
Fax
qq：1580084073
Email
1580084073@qq.com
Country
China
ProdList
663
Advantage
58
JinOu Biomedical (Nanjing) Co., Ltd.
Tel
13000000000
Fax
jinoupharma@163
Email
jinoupharma@163.com
Country
China
ProdList
11721
Advantage
58
Changzhou Bojia Biomedical Technology Co., Ltd.
Tel
2122619822
Email
czbjpharma@126.com
Country
China
ProdList
18478
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24644
Advantage
58

1084893-56-0, (S)-CR8Related Search:

Indirubin RP107 KENPAULLONE INDIRUBIN-3'-MONOXIME Alsterpaullone

  • CR8, (S)-Isomer - CAS 1084893-56-0 - Calbiochem
  • 1-Butanol, 2-[[9-(1-methylethyl)-6-[[[4-(2-pyridinyl)phenyl]methyl]amino]-9H-purin-2-yl]amino]-, (2S)-
  • CR8, (S)-Isomer
  • (S)-CR8, CDK 1, 2, 5, 7 and 9 inhibitor
  • 1084893-56-0