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RP107

Product Name
RP107
CAS No.
496864-16-5
Chemical Name
RP107
Synonyms
RP107;ALOISINE A;ALOISINE A RP107;Aloisine A - CAS 496864-16-5 - Calbiochem;4-(7-Butyl-4H-pyrrolo[2,3-b]pyrazin-6-yl)phenol;4-(7-BUTYL-5H-PYRROLO[2,3-B]PYRAZIN-6-YL)-PHENOL;Phenol, 4-(7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)-;7-Butyl-6-(4-hydroxyphenyl)-5H-pyrrolo[2,3-b]pyrazine;7-N-BUTYL-6-(4-HYDROXPHENYL)[5H]PYRROLO[2,3-B]PYRAZINE;7-N-BUTYL-6-(4-HYDROXYPHENYL)-[5H]PYRROLO[2,3-B]PYRAZINE
CBNumber
CB4265483
Molecular Formula
C16H17N3O
Formula Weight
267.33
MOL File
496864-16-5.mol
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RP107 Property

Melting point:
281-283°C
Density 
1.227
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Yellow solid
pka
9.67±0.15(Predicted)
color 
Light Orangish Yellow
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Safety

Risk Statements 
36/37/38
Safety Statements 
26-36/37
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
128125
Product name
Aloisine A - CAS 496864-16-5 - Calbiochem<br />A cell-permeable pyrrolo-pyrazine compound that exerts anti-proliferative effects.
Packaging
5mg
Price
$187
Updated
2024/03/01
TRC
Product number
A575450
Product name
AloisineARP107
Packaging
100mg
Price
$1175
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA17320
Product name
Aloisine A RP107
Packaging
1mg
Price
$65
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA17320
Product name
Aloisine A RP107
Packaging
2mg
Price
$100
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA17320
Product name
Aloisine A RP107
Packaging
5mg
Price
$200
Updated
2021/12/16
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RP107 Chemical Properties,Usage,Production

Chemical Properties

Yellow solid

Uses

A cell-permeable pyrrolo-pyrazine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of cyclin dependent kinases (Cdks: IC50 =150nM, 120 nM, 400 nM and 200 nM for Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p25,

Definition

ChEBI: 4-(7-butyl-1,5-dihydropyrrolo[2,3-b]pyrazin-6-ylidene)-1-cyclohexa-2,5-dienone is a member of quinomethanes.

General Description

A cell-permeable pyrrolo-pyrazine compound that exerts anti-proliferative effects. Acts as a potent, selective, reversible, and ATP-competitive inhibitor of cyclin-dependent kinases (Cdks; IC50 = 150 nM, 120 nM, 400 nM, and 200 nM for Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p25, respectively), glycogen synthase kinase-3 (GSK-3; IC50 = 500 nM and 1.5 μM for GSK-3α, GSK-3β, respectively), and c-Jun N-terminal kinase (JNK; IC50 = ~ 3 - 10 μM). It inhibits several other enzymes (CK1, CK2, MAPKK, PKA, PKG, PKCs, and c-raf) poorly (IC50 ≥ 100 μM). Shown to arrest cells in both G1 and G2 phases (IC50 = 7 μM and 10.5 μM for undifferentiated human teratocarcinoma cells NT2 and differentiated postmitotic neurons hNT, respectively). Shown to selectively stimulate CFTR-dependent iodide efflux in wtCFTR-CHO, Calu-3 and F508del-CFTR-CF15 cells in the presence of 1 μM Forskolin (Cat. No. 344270) with high affinity (EC50 = 150 nM, 140 nM and 111 nM, respectively).

Biochem/physiol Actions

EC50 = 150 nM, 140 nM and 111 nM, in stimulating CFTR-dependent iodide efflux in wtCFTR-CHO, Calu-3 and F508del-CFTR-CF15 cells in the presence of 1 μM Forskolin, respectively

RP107 Preparation Products And Raw materials

Raw materials

Preparation Products

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RP107 Suppliers

Canada 1 China 44 Switzerland 1 United Kingdom 1 United States 9 USA 1 Global 57
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
Advantage
69
Shanghai Paulshine Chemical Co., Ltd.
Tel
+86-021-37788663
Fax
+86-021-37788663
Country
China
ProdList
186
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
SynAsst Chemical.
Tel
021-60343070
Fax
021-35122006
Country
China
ProdList
12742
Advantage
55
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51471
Advantage
80
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9709
Advantage
58
Zhengzhou Acme Chemical Co., Ltd.
Tel
0371-0371-55629727 13323845623
Fax
037155629727
Email
2885676761@qq.com
Country
China
ProdList
9859
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131981
Advantage
58
Chengdu Senior Pharma Technology Co.Ltd.
Tel
+86-0838-2319818 +86-15982001943
Email
seniorpharma@163.com
Country
China
ProdList
411
Advantage
55

496864-16-5, RP107Related Search:

tert-Butyl methyl ether Indirubin (S)-CR8 KENPAULLONE INDIRUBIN-3'-MONOXIME Alsterpaullone PTH-RP (107-111) (HUMAN, BOVINE, DOG, HORSE, MOUSE, RABBIT, RAT),PTH-RP (107-111) (HUMAN, RAT) PTH-RP (107-111) AMIDE (HUMAN, BOVINE, DOG, HORSE, MOUSE, RABBIT, RAT),PTH-RP (107-111) AMIDE (HUMAN, RAT) RP107 RP106 2-PHENYL-4,7-DIAZAINDOLE

  • RP107
  • 4-(7-BUTYL-5H-PYRROLO[2,3-B]PYRAZIN-6-YL)-PHENOL
  • ALOISINE A
  • ALOISINE A RP107
  • 7-N-BUTYL-6-(4-HYDROXPHENYL)[5H]PYRROLO[2,3-B]PYRAZINE
  • 7-N-BUTYL-6-(4-HYDROXYPHENYL)-[5H]PYRROLO[2,3-B]PYRAZINE
  • RP107, 7-n-Butyl-6-(4-hydroxyphenyl)-[5H]pyrrolo[2,3-b]pyrazine
  • RP107, 7-n-Butyl-6-(4-hydroxyphenyl)-[5H]pyrrolo[2,3-β]pyrazine
  • 4-(7-Butyl-4H-pyrrolo[2,3-b]pyrazin-6-yl)phenol
  • 7-Butyl-6-(4-hydroxyphenyl)-5H-pyrrolo[2,3-b]pyrazine
  • Aloisine A - CAS 496864-16-5 - Calbiochem
  • Phenol, 4-(7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)-
  • 4-(7-butyl-1,5-dihydropyrrolo[2,3-b]pyrazin-6-ylidene)cyclohexa-2,5-dien-1-one
  • 4-(7-butyl-l,5-dihydropyrrolo[2,3-b]pyrazin-6-ylidene)cyclohexa-2,5-dien-l-one
  • 496864-16-5
  • All Inhibitors
  • Inhibitors
  • Protein Kinase Inhibitors and Activators
  • Aromatics
  • Heterocycles