RP107
- Product Name
- RP107
- CAS No.
- 496864-16-5
- Chemical Name
- RP107
- Synonyms
- RP107;ALOISINE A;ALOISINE A RP107;Aloisine A - CAS 496864-16-5 - Calbiochem;4-(7-Butyl-4H-pyrrolo[2,3-b]pyrazin-6-yl)phenol;4-(7-BUTYL-5H-PYRROLO[2,3-B]PYRAZIN-6-YL)-PHENOL;Phenol, 4-(7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)-;7-Butyl-6-(4-hydroxyphenyl)-5H-pyrrolo[2,3-b]pyrazine;7-N-BUTYL-6-(4-HYDROXPHENYL)[5H]PYRROLO[2,3-B]PYRAZINE;7-N-BUTYL-6-(4-HYDROXYPHENYL)-[5H]PYRROLO[2,3-B]PYRAZINE
- CBNumber
- CB4265483
- Molecular Formula
- C16H17N3O
- Formula Weight
- 267.33
- MOL File
- 496864-16-5.mol
RP107 Property
- Melting point:
- 281-283°C
- Density
- 1.227
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Yellow solid
- pka
- 9.67±0.15(Predicted)
- color
- Light Orangish Yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 128125
- Product name
- Aloisine A - CAS 496864-16-5 - Calbiochem<br />A cell-permeable pyrrolo-pyrazine compound that exerts anti-proliferative effects.
- Packaging
- 5mg
- Price
- $187
- Updated
- 2024/03/01
- Product number
- A575450
- Product name
- AloisineARP107
- Packaging
- 100mg
- Price
- $1175
- Updated
- 2021/12/16
- Product number
- FA17320
- Product name
- Aloisine A RP107
- Packaging
- 1mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FA17320
- Product name
- Aloisine A RP107
- Packaging
- 2mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FA17320
- Product name
- Aloisine A RP107
- Packaging
- 5mg
- Price
- $200
- Updated
- 2021/12/16
RP107 Chemical Properties,Usage,Production
Chemical Properties
Yellow solid
Uses
A cell-permeable pyrrolo-pyrazine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of cyclin dependent kinases (Cdks: IC50 =150nM, 120 nM, 400 nM and 200 nM for Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p25,
Definition
ChEBI: 4-(7-butyl-1,5-dihydropyrrolo[2,3-b]pyrazin-6-ylidene)-1-cyclohexa-2,5-dienone is a member of quinomethanes.
General Description
A cell-permeable pyrrolo-pyrazine compound that exerts anti-proliferative effects. Acts as a potent, selective, reversible, and ATP-competitive inhibitor of cyclin-dependent kinases (Cdks; IC50 = 150 nM, 120 nM, 400 nM, and 200 nM for Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p25, respectively), glycogen synthase kinase-3 (GSK-3; IC50 = 500 nM and 1.5 μM for GSK-3α, GSK-3β, respectively), and c-Jun N-terminal kinase (JNK; IC50 = ~ 3 - 10 μM). It inhibits several other enzymes (CK1, CK2, MAPKK, PKA, PKG, PKCs, and c-raf) poorly (IC50 ≥ 100 μM). Shown to arrest cells in both G1 and G2 phases (IC50 = 7 μM and 10.5 μM for undifferentiated human teratocarcinoma cells NT2 and differentiated postmitotic neurons hNT, respectively). Shown to selectively stimulate CFTR-dependent iodide efflux in wtCFTR-CHO, Calu-3 and F508del-CFTR-CF15 cells in the presence of 1 μM Forskolin (Cat. No. 344270) with high affinity (EC50 = 150 nM, 140 nM and 111 nM, respectively).
Biochem/physiol Actions
EC50 = 150 nM, 140 nM and 111 nM, in stimulating CFTR-dependent iodide efflux in wtCFTR-CHO, Calu-3 and F508del-CFTR-CF15 cells in the presence of 1 μM Forskolin, respectively