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(S)-CR8

Product Name
(S)-CR8
CAS No.
1084893-56-0
Chemical Name
(S)-CR8
Synonyms
CR8, (S)-Isomer;(S)-CR8, CDK 1, 2, 5, 7 and 9 inhibitor;CR8, (S)-Isomer - CAS 1084893-56-0 - Calbiochem;(S)-2-((9-Isopropyl-6-((4-(pyridin-2-yl)benzyl)amino)-9H-purin-2-yl)amino)butan-1-ol;1-Butanol, 2-[[9-(1-methylethyl)-6-[[[4-(2-pyridinyl)phenyl]methyl]amino]-9H-purin-2-yl]amino]-, (2S)-
CBNumber
CB33152923
Molecular Formula
C24H29N7O
Formula Weight
431.53
MOL File
1084893-56-0.mol
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(S)-CR8 Property

Boiling point:
671.4±65.0 °C(Predicted)
Density 
1.27±0.1 g/cm3(Predicted)
storage temp. 
+2C to +8C
solubility 
DMSO: soluble,Ethanol: soluble
form 
Off-white solid
pka
14.56±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
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N-Bromosuccinimide Price

Cayman Chemical
Product number
29985
Product name
(S)-CR8
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
29985
Product name
(S)-CR8
Packaging
25mg
Price
$479
Updated
2024/03/01
Cayman Chemical
Product number
29985
Product name
(S)-CR8
Packaging
5mg
Price
$183
Updated
2024/03/01
Cayman Chemical
Product number
29985
Product name
(S)-CR8
Packaging
10mg
Price
$278
Updated
2024/03/01
Adipogen Life Sciences
Product number
AG-MR-C0004-M010
Product name
(S)-CR8
Purity
≥99%(NMR)
Packaging
10mg
Price
$200
Updated
2021/12/16
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(S)-CR8 Chemical Properties,Usage,Production

Description

(S)-CR8 is a second generation derivative of (R)-roscovitine and an inhibitor of cyclin-dependent kinase 1 (Cdk1/cyclin B), Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p25, and Cdk9/cyclin T (IC50s = 0.15, 0.08, 0.06, 0.12, and 0.11 μM, respectively). It also inhibits casein kinase CK1δ/ε (CKδ/ε) and DYRK1A (IC50s = 0.61 and 0.9 μM, respectively). (S)-CR8 reduces cell viability in human neuroblastoma cell lines, including SH-SY5Y, SK-N-AS, SK-N-BE, and IMR32 cells (IC50s = 0.43, 1.46, 0.13, and 0.14 μM, respectively). It also reduces protein levels of the survival factor Mcl-1 in SH-SY5Y cells.

Uses

(S)-CR8 is the S-isomer of CR8. (S)-CR8 is a potent and selective CDK inhibitor with IC50s of 0.060, 0.080, 0.11, 0.12, and 0.15 μM for CDK2/cyclin E, CDK2/cyclin A, CDK9/cyclin T, CDK5/p25, and CDK1/cyclin B, respectively. (S)-CR8 reduces SH-SY5Y cells survival (IC50 0.40?μM)[1].

Definition

ChEBI: (2S)-2-[[9-propan-2-yl-6-[[4-(2-pyridinyl)phenyl]methylamino]-2-purinyl]amino]-1-butanol is a phenylpyridine.

References

[1] K Bettayeb, et al. CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases. Oncogene. 2008 Oct 2;27(44):5797-807. DOI:10.1038/onc.2008.191

(S)-CR8 Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-CR8 Suppliers

China 18 United States 6 Global 24
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
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58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52923
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58
Abcam Limited
Tel
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Email
us.orders@abcam.com
Country
United States
ProdList
6001
Advantage
50
Cayman Chemical Company
Tel
--
Fax
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Email
cayman@caymanchem.com
Country
United States
ProdList
6213
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81
Riedel-de Haen AG
Tel
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Country
United States
ProdList
6773
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87

1084893-56-0, (S)-CR8Related Search:

Indirubin RP107 KENPAULLONE INDIRUBIN-3'-MONOXIME Alsterpaullone

  • CR8, (S)-Isomer - CAS 1084893-56-0 - Calbiochem
  • 1-Butanol, 2-[[9-(1-methylethyl)-6-[[[4-(2-pyridinyl)phenyl]methyl]amino]-9H-purin-2-yl]amino]-, (2S)-
  • CR8, (S)-Isomer
  • (S)-CR8, CDK 1, 2, 5, 7 and 9 inhibitor
  • (S)-2-((9-Isopropyl-6-((4-(pyridin-2-yl)benzyl)amino)-9H-purin-2-yl)amino)butan-1-ol
  • 1084893-56-0