BAR 501
- Product Name
- BAR 501
- CAS No.
- 1632118-69-4
- Chemical Name
- BAR 501
- Synonyms
- BAR 501;CPDD0945;BAR 501; BAR-501;BAR501, 10 mM in DMSO;Cholane-3,7,24-triol, 6-ethyl-, (3α,5β,6β,7β)-;BAR501, 98%, a potent and selective agonist of GPBAR1;Inhibitor,GPBAR1,TGR5,GPCR19,G-protein coupled receptor 19,BAR-501,BAR501,G protein-coupled Bile Acid Receptor 1,inhibit;(3R,5S,6S,7S,8S,9S,10S,13R,14S,17R)-6-ethyl-17-((R)-5-hydroxypentan-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol
- CBNumber
- CB33153036
- Molecular Formula
- C26H46O3
- Formula Weight
- 406.64
- MOL File
- 1632118-69-4.mol
BAR 501 Property
- Boiling point:
- 527.6±25.0 °C(Predicted)
- Density
- 1.047±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:65.5(Max Conc. mg/mL);161.07(Max Conc. mM)
DMF:20.0(Max Conc. mg/mL);49.18(Max Conc. mM)
Ethanol:34.33(Max Conc. mg/mL);84.42(Max Conc. mM) - form
- A crystalline solid
- pka
- 14.82±0.70(Predicted)
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- 22460
- Product name
- BAR501
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 22460
- Product name
- BAR501
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $161
- Updated
- 2024/03/01
- Product number
- 22460
- Product name
- BAR501
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $283
- Updated
- 2024/03/01
- Product number
- 22460
- Product name
- BAR501
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $618
- Updated
- 2024/03/01
- Product number
- BB178048
- Product name
- BAR-501
- Packaging
- 25mg
- Price
- $700
- Updated
- 2021/12/16
BAR 501 Chemical Properties,Usage,Production
Uses
BAR501 is a potent and selective agonist of GPBAR1 with an EC50 of 1 μM.
in vivo
Pretreating rats for 6 days with BAR501, 15 mg/kg, reduces basal portal pressure and blunts the vasoconstriction activity of norepinephrine. Pretreatment with BAR501 attenuates the hepatic vasomotor activity induced by shear stress and methoxamine. Administration of BAR501 exerts a direct vasodilatory activity in the CCl4 model. Treating mice with BAR501 at the dose of 15 mg/Kg reduces portal pressure and AST plasma levels. BAR501 attenuates endothelial dysfunction by regulating CSE expression/activity[1].
References
[1] Renga B, et al. Reversal of Endothelial Dysfunction by GPBAR1 Agonism in Portal Hypertension Involves a AKT/FOXOA1 Dependent Regulation of H2S Generation and Endothelin-1. PLoS One. 2015 Nov 5;10(11):e0141082. DOI:10.1371/journal.pone.0141082
BAR 501 Preparation Products And Raw materials
Raw materials
Preparation Products
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