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ADU-S100 ammonium salt

Product Name
ADU-S100 ammonium salt
CAS No.
1638750-96-5
Chemical Name
ADU-S100 ammonium salt
Synonyms
MIW815 ammonium salt;ADU-S100 ammonium salt;ML RR-S2 CDA (ammonium salt);STING-INDUCER-1 AMMONIUM SALT;ML RR-S2 CDA ammonium salt(ADU-S100);ADU-S100 ammonium salt, 10 mM in DMSO;Adenosine, [P(R)]-5'-O-[(R)-hydroxymercaptophosphinyl]-P-thioadenylyl-(2'→5')-, cyclic nucleotide, ammonium salt (1:2);inhibit,ADU S100 ammonium salt,TMEM173,STING,MIW815,Inhibitor,MIW-815,Stimulator of Interferon Genes,MITA,MPYS,ERIS,ADU-S100,ML RR-S2 CDA,MIW 815,ADUS100 ammonium salt
CBNumber
CB33155065
Molecular Formula
C20H27N11O10P2S2
Formula Weight
707.57
MOL File
1638750-96-5.mol
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ADU-S100 ammonium salt Property

storage temp. 
Store at -20°C
solubility 
DMSO: 15 mg/ml; Water: 12.5 mg/ml
form 
A solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
24106
Product name
ML RR-S2 CDA (ammonium salt)
Purity
≥98%
Packaging
500μg
Price
$778
Updated
2024/03/01
Cayman Chemical
Product number
24106
Product name
ML RR-S2 CDA (ammonium salt)
Purity
≥98%
Packaging
1mg
Price
$1164
Updated
2024/03/01
ChemScene
Product number
CS-6093
Product name
ADU-S100ammoniumsalt
Purity
99.44%
Packaging
1mg
Price
$195
Updated
2021/12/16
ChemScene
Product number
CS-6093
Product name
ADU-S100ammoniumsalt
Purity
99.44%
Packaging
5mg
Price
$645
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611556
Product name
ML RR-S2 CDA ammonium salt
Purity
>98%
Packaging
5mg
Price
$765
Updated
2021/12/16
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ADU-S100 ammonium salt Chemical Properties,Usage,Production

Description

ML RR-S2 CDA is a synthetic cyclic dinucleotide (CDN) that contains non-canonical 2''5''-phosphodiester bonds and is an activator of stimulator of interferon genes (STING). It contains mixed linkages (ML) with both 2''5'' and 3''5'' linkages, which leads to increased thermal stability of human STING in a differential scanning fluorimetry (DSF) assay. ML RR-S2 CDA increases type I interferon production by THP-1 human monocytes relative to unmodified cyclic di-AMP (CDA; ), indicating the ML enhances its action at human STING. It induces expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and Mcp-1 in murine bone marrow macrophages (BMM) isolated from wild-type, but not STING-/-, mice. ML RR-S2 CDA also induces IFN-β expression in peripheral blood mononuclear cells (PBMCs) isolated from donors carrying STINGWT/WT, STINGWT/REF, and STINGWT/HAQ alleles. In vivo, ML RR-S2 CDA initiates tumor regression and prevents tumor growth upon tumor cell reimplantation in 4T1 murine mammary and CT26 murine colon cancer models.

Uses

2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt (ADU-S100 ammonium salt), an activator of stimulator of interferon genes (STING), leads to potent and systemic tumor regression and immunity[1].

in vivo

2’3’-c-di-AM(PS)2 (Rp,Rp) shows higher anti-tumor control than the endogenous ML cGAMP. A dose response of the 2’3’-c-di-AM(PS)2 (Rp,Rp) compound is performed in B16 tumor-bearing mice, which identifies an optimal antitumor dose level that also elicites maximum tumor antigen-specific CD8+ T cell responses, and improves long-term survival to 50%[1].

References

[1] Corrales L, et al. Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity. Cell Rep. 2015 May 19;11(7):1018-30. DOI:10.1016/j.celrep.2015.04.031

ADU-S100 ammonium salt Preparation Products And Raw materials

Raw materials

Preparation Products

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ADU-S100 ammonium salt Suppliers

China 37 United States 8 Global 45
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
Advantage
65
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 18101056239
Email
3193328036@qq.com
Country
China
ProdList
29760
Advantage
68
Heze Development Zone chuangli Chemical Co., Ltd.
Tel
0530-+86-530-529 6766，+86-15666160102 15666160102
Fax
0530-529 6766
Email
info@chuangli-chem.com
Country
China
ProdList
836
Advantage
55
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58

1638750-96-5, ADU-S100 ammonium saltRelated Search:

Ammonia

  • ML RR-S2 CDA (ammonium salt)
  • Adenosine, [P(R)]-5'-O-[(R)-hydroxymercaptophosphinyl]-P-thioadenylyl-(2'→5')-, cyclic nucleotide, ammonium salt (1:2)
  • ADU-S100 ammonium salt
  • STING-INDUCER-1 AMMONIUM SALT
  • MIW815 ammonium salt
  • ML RR-S2 CDA ammonium salt(ADU-S100)
  • inhibit,ADU S100 ammonium salt,TMEM173,STING,MIW815,Inhibitor,MIW-815,Stimulator of Interferon Genes,MITA,MPYS,ERIS,ADU-S100,ML RR-S2 CDA,MIW 815,ADUS100 ammonium salt
  • ADU-S100 ammonium salt, 10 mM in DMSO
  • 1638750-96-5