Esaxerenone

Product Name: Esaxerenone
CAS No.: 1632006-28-0
Chemical Name: Esaxerenone
Synonyms: cs3150;cs-3150;CS-2614;XL-550);RMA-888;Esaxerenone;5G,100G,500G;ESAXERENONE WS;Esaxerenone(CS-3150);CS-3150 (Esaxerenone
CBNumber: CB33159937
Molecular Formula: C22H21F3N2O4S
Formula Weight: 466.48
MOL File: 1632006-28-0.mol

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Esaxerenone Property

Boiling point:: 581.3±50.0 °C(Predicted)
Density: 1.35±0.1 g/cm3(Predicted)
solubility: DMSO:100.0(Max Conc. mg/mL);214.37(Max Conc. mM)
pka: 12.76±0.70(Predicted)
form: Solid
color: White to light yellow
InChI: InChI=1S/C22H21F3N2O4S/c1-14-18(21(29)26-15-7-9-16(10-8-15)32(2,30)31)13-27(11-12-28)20(14)17-5-3-4-6-19(17)22(23,24)25/h3-10,13,28H,11-12H2,1-2H3,(H,26,29)
InChIKey: NOSNHVJANRODGR-UHFFFAOYSA-N
SMILES: C(N1C=C(C(=O)NC2C=CC(S(=O)(=O)C)=CC=2)C(C)=C1C1C=CC=CC=1C(F)(F)F)CO

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 41082
Product name: Esaxerenone
Purity: ≥98%
Packaging: 5mg
Price: $149
Updated: 2026/04/30

Cayman Chemical

Product number: 41082
Product name: Esaxerenone
Purity: ≥98%
Packaging: 10mg
Price: $268
Updated: 2026/04/30

Cayman Chemical

Product number: 41082
Product name: Esaxerenone
Purity: ≥98%
Packaging: 50mg
Price: $818
Updated: 2026/04/30

Cayman Chemical

Product number: 41082
Product name: Esaxerenone
Purity: ≥98%
Packaging: 100mg
Price: $1337
Updated: 2026/04/30

TRC

Product number: E888295
Product name: Esaxerenone
Packaging: 10mg
Price: $270
Updated: 2021/12/16

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Esaxerenone Chemical Properties,Usage,Production

Uses

Esaxerenone, is a novel, highly potent and selective non-steroidal mineralocorticoid receptor antagonist.

Biological Activity

Esaxerenone exerts its antihypertensive effect by blocking excessive activation of the mineralocorticoid receptor by endogenous ligands (such as aldosterone), has a mineralocorticoid receptor selectivity at least 1000-fold greater than other steroid hormone receptors, a long half-life, high oral bioavailability, and has a more significant antihypertensive effect than spironolactone or eplerenone.

Synthesis

below shows the synthesis route of Esaxerenone

in vivo

After single oral administration of Esaxerenone at 0.1, 0.3, 1, and 3mg/kg, maximum plasma concentration (C_max) and the area under the plasma concentration versus time curve (AUC) are increased with dose. Time to reach the maximum plasma concentration (T_max) of Esaxerenone ranges from 2.0 to 4.5h. After intravenous administration of Esaxerenone at 0.1, 0.3, 1, and 3mg/kg, the total body clearance (CL) and distribution volume at steady state (V_ss) are 3.53 to 6.69mL/min/kg and 1.47 to 2.49L/kg, respectively, in rats, and 2.79 to 3.69mL/min/kg and 1.34 to 1.54L/kg, respectively, in cynomolgus monkeys. Up to 168h after administration, 3.9% and 91.4% of dosed radioactivity are excreted in rat urine and feces, respectively, and 95.2% in total. In monkeys, the excreted radioactivity up to 168h is 11.5% in urine, 82.3% in feces, and 93.9% in total^[1].

Esaxerenone Preparation Products And Raw materials

Raw materials

Preparation Products

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Esaxerenone Suppliers

China 68 India 1 United States 5 USA 1 Global 75

Nanjing Vcare PharmaTech Co., Ltd

Tel: 025-58741518 13327700685
Email: sales@vcarepharmatech.com
Country: China
ProdList: 487
Advantage: 58

WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

Tel: 17702719238 18971495150;
Email: sales@sun-shinechem.com
Country: China
ProdList: 1150
Advantage: 64

Shanghai Famo Bio-chemical Technology Company Ltd.

Tel: 02136680027 15800370750
Email: 1706640024@qq.com
Country: China
ProdList: 485
Advantage: 56

Valiant Co., Ltd.

Tel: 0535-6101880
Fax: 0535-6386989
Email: liutao@valiant-cn.com
Country: China
ProdList: 286
Advantage: 60

Bide Pharmatech Ltd.

Tel: 400-400-164-7117 18317119277
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39999
Advantage: 60

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4827
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 89689
Advantage: 60

Shanghai Biopharmaleader Co., Ltd.

Tel: +86 18721201413
Fax: +86 (21) 5775-8967
Email: sales@biopharmaleader.com
Country: China
ProdList: 1720
Advantage: 58

Wuhan Sun-shine Bio-technology Corporation Limited

Tel: +86-027-6552-2453
Email: sales@sun-shinechem.com
Country: China
ProdList: 727
Advantage: 58

Niuruisi Medical Technology Co. Ltd.

Tel: 13872091715
Email: cheng1297@126.com
Country: China
ProdList: 282
Advantage: 58

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View Lastest Price from Esaxerenone manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: Esaxerenone 1632006-28-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-06-07

1632006-28-0, EsaxerenoneRelated Search:

cs3150

cs-3150

Esaxerenone

CS-3150 (Esaxerenone

XL-550)

CS-2614

5G,100G,500G

CS-3150; CS 3150; CS3150; XL-550; XL550; XL 550.

1H-Pyrrole-3-carboxamide, 1-(2-hydroxyethyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-5-[2-(trifluoromethyl)phenyl]-, (5S)-

1-(2-hydroxyethyl)-4-methyl-N-(4-methylsulfonylphenyl)-5-[2-(trifluoromethyl)phenyl]pyrrole-3-carboxamide

Esaxerenone(CS-3150)

Esaxerenone,Inhibitor,Mineralocorticoid Receptor,CS 3150,CS3150,inhibit,XL550,XL 550

1-(2-Hydroxyethyl)-4-methyl-N-(4-(methylsulfonyl)phenyl)-5-(2-(trifluoromethyl)phenyl)-1H-pyrrole-3-carboxamide

Esaxerenone, 10 mM in DMSO

1-(2-Hydroxyethyl)-4-methyl-N-(4-(methylsulfonyl)phenyl)-5-(2-(trifluoromethyl)phenyl)-1H-pyrrole-3-carboxamide , Esaxerenone

(5P)-1-(2-Hydroxyethyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-5-[2- (trifluoromethyl) phenyl]-1H-pyrrole-3-carboxamide

RMA-888

ESAXERENONE WS

1632006-28-0