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Esaxerenone

Product Name
Esaxerenone
CAS No.
1632006-28-0
Chemical Name
Esaxerenone
Synonyms
cs3150;cs-3150;CS-2614;XL-550);Esaxerenone;5G,100G,500G;Esaxerenone(CS-3150);CS-3150 (Esaxerenone;Esaxerenone, 10 mM in DMSO;CS-3150; CS 3150; CS3150; XL-550; XL550; XL 550.
CBNumber
CB33159937
Molecular Formula
C22H21F3N2O4S
Formula Weight
466.48
MOL File
1632006-28-0.mol
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Esaxerenone Property

Boiling point:
581.3±50.0 °C(Predicted)
Density 
1.35±0.1 g/cm3(Predicted)
solubility 
DMSO:100.0(Max Conc. mg/mL);214.37(Max Conc. mM)
pka
12.76±0.70(Predicted)
form 
Solid
color 
White to light yellow
InChI
InChI=1S/C22H21F3N2O4S/c1-14-18(21(29)26-15-7-9-16(10-8-15)32(2,30)31)13-27(11-12-28)20(14)17-5-3-4-6-19(17)22(23,24)25/h3-10,13,28H,11-12H2,1-2H3,(H,26,29)
InChIKey
NOSNHVJANRODGR-UHFFFAOYSA-N
SMILES
C(N1C=C(C(=O)NC2C=CC(S(=O)(=O)C)=CC=2)C(C)=C1C1C=CC=CC=1C(F)(F)F)CO
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
E888295
Product name
Esaxerenone
Packaging
10mg
Price
$270
Updated
2021/12/16
ChemScene
Product number
CS-8044
Product name
Esaxerenone
Purity
99.84%
Packaging
5mg
Price
$396
Updated
2021/12/16
ChemScene
Product number
CS-8044
Product name
Esaxerenone
Purity
99.84%
Packaging
10mg
Price
$600
Updated
2021/12/16
ChemScene
Product number
CS-8044
Product name
Esaxerenone
Purity
99.84%
Packaging
50mg
Price
$1800
Updated
2021/12/16
ChemScene
Product number
CS-8044
Product name
Esaxerenone
Purity
99.84%
Packaging
100mg
Price
$2520
Updated
2021/12/16
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Esaxerenone Chemical Properties,Usage,Production

Uses

Esaxerenone, is a novel, highly potent and selective non-steroidal mineralocorticoid receptor antagonist.

Biological Activity

Esaxerenone exerts its antihypertensive effect by blocking excessive activation of the mineralocorticoid receptor by endogenous ligands (such as aldosterone), has a mineralocorticoid receptor selectivity at least 1000-fold greater than other steroid hormone receptors, a long half-life, high oral bioavailability, and has a more significant antihypertensive effect than spironolactone or eplerenone.

Synthesis

below shows the synthesis route of Esaxerenone

in vivo

After single oral administration of Esaxerenone at 0.1, 0.3, 1, and 3?mg/kg, maximum plasma concentration (Cmax) and the area under the plasma concentration versus time curve (AUC) are increased with dose. Time to reach the maximum plasma concentration (Tmax) of Esaxerenone ranges from 2.0 to 4.5?h. After intravenous administration of Esaxerenone at 0.1, 0.3, 1, and 3?mg/kg, the total body clearance (CL) and distribution volume at steady state (Vss) are 3.53 to 6.69?mL/min/kg and 1.47 to 2.49?L/kg, respectively, in rats, and 2.79 to 3.69?mL/min/kg and 1.34 to 1.54?L/kg, respectively, in cynomolgus monkeys. Up to 168?h after administration, 3.9% and 91.4% of dosed radioactivity are excreted in rat urine and feces, respectively, and 95.2% in total. In monkeys, the excreted radioactivity up to 168?h is 11.5% in urine, 82.3% in feces, and 93.9% in total[1].

Esaxerenone Preparation Products And Raw materials

Raw materials

Preparation Products

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Esaxerenone Suppliers

China 65 India 1 United States 5 USA 1 Global 72
Nanjing Vcare PharmaTech Co., Ltd
Tel
025-58741518 13327700685
Email
sales@vcarepharmatech.com
Country
China
ProdList
506
Advantage
58
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
Tel
17702719238 18971495150;
Email
sales@sun-shinechem.com
Country
China
ProdList
1077
Advantage
64
Shanghai Famo Bio-chemical Technology Company Ltd.
Tel
021-02136680027 15800370750
Email
1706640024@qq.com
Country
China
ProdList
570
Advantage
56
Taizhou Tongxin Bio-Tech Co., Ltd
Tel
0523-86818997 18652728585
Email
sales@allyrise.com
Country
China
ProdList
2966
Advantage
60
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
Advantage
55
Shanghai SuperLan Chemcial Technique Centre
Tel
0-2022843681 15618226720
Fax
+86-21-51601218
Email
chaolaichem@foxmail.com
Country
China
ProdList
12476
Advantage
58
Shanghai Biopharmaleader Co., Ltd.
Tel
+86 18721201413
Fax
+86 (21) 5775-8967
Email
sales@biopharmaleader.com
Country
China
ProdList
1720
Advantage
58
Wuhan Sun-shine Bio-technology Corporation Limited
Tel
+86-027-6552-2453
Email
sales@sun-shinechem.com
Country
China
ProdList
727
Advantage
58
Niuruisi Medical Technology Co. Ltd.
Tel
13872091715
Email
cheng1297@126.com
Country
China
ProdList
291
Advantage
58
Chongqing Genco Pharmaceutical Co.,Ltd
Tel
023-88654579 13637703915
Fax
375097861
Email
375097861@qq.com
Country
China
ProdList
282
Advantage
58
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View Lastest Price from Esaxerenone manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
Esaxerenone 1632006-28-0
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kg
Release date
2025-06-07

1632006-28-0, EsaxerenoneRelated Search:


  • cs3150
  • cs-3150
  • Esaxerenone
  • CS-3150 (Esaxerenone
  • XL-550)
  • CS-2614
  • 5G,100G,500G
  • CS-3150; CS 3150; CS3150; XL-550; XL550; XL 550.
  • 1H-Pyrrole-3-carboxamide, 1-(2-hydroxyethyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-5-[2-(trifluoromethyl)phenyl]-, (5S)-
  • 1-(2-hydroxyethyl)-4-methyl-N-(4-methylsulfonylphenyl)-5-[2-(trifluoromethyl)phenyl]pyrrole-3-carboxamide
  • Esaxerenone(CS-3150)
  • Esaxerenone,Inhibitor,Mineralocorticoid Receptor,CS 3150,CS3150,inhibit,XL550,XL 550
  • 1-(2-Hydroxyethyl)-4-methyl-N-(4-(methylsulfonyl)phenyl)-5-(2-(trifluoromethyl)phenyl)-1H-pyrrole-3-carboxamide
  • Esaxerenone, 10 mM in DMSO
  • 1-(2-Hydroxyethyl)-4-methyl-N-(4-(methylsulfonyl)phenyl)-5-(2-(trifluoromethyl)phenyl)-1H-pyrrole-3-carboxamide , Esaxerenone
  • (5P)-1-(2-Hydroxyethyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-5-[2- (trifluoromethyl) phenyl]-1H-pyrrole-3-carboxamide
  • 1632006-28-0