ChemicalBook > CAS DataBase List > Esaxerenone

Esaxerenone

Product Name
Esaxerenone
CAS No.
1632006-28-0
Chemical Name
Esaxerenone
Synonyms
cs3150;cs-3150;CS-2614;XL-550);RMA-888;Esaxerenone;5G,100G,500G;ESAXERENONE WS;Esaxerenone(CS-3150);CS-3150 (Esaxerenone
CBNumber
CB33159937
Molecular Formula
C22H21F3N2O4S
Formula Weight
466.48
MOL File
1632006-28-0.mol
More
Less

Esaxerenone Property

Boiling point:
581.3±50.0 °C(Predicted)
Density 
1.35±0.1 g/cm3(Predicted)
solubility 
DMSO:100.0(Max Conc. mg/mL);214.37(Max Conc. mM)
pka
12.76±0.70(Predicted)
form 
Solid
color 
White to light yellow
InChI
InChI=1S/C22H21F3N2O4S/c1-14-18(21(29)26-15-7-9-16(10-8-15)32(2,30)31)13-27(11-12-28)20(14)17-5-3-4-6-19(17)22(23,24)25/h3-10,13,28H,11-12H2,1-2H3,(H,26,29)
InChIKey
NOSNHVJANRODGR-UHFFFAOYSA-N
SMILES
C(N1C=C(C(=O)NC2C=CC(S(=O)(=O)C)=CC=2)C(C)=C1C1C=CC=CC=1C(F)(F)F)CO
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

More
Less

N-Bromosuccinimide Price

TRC
Product number
E888295
Product name
Esaxerenone
Packaging
10mg
Price
$270
Updated
2021/12/16
ChemScene
Product number
CS-8044
Product name
Esaxerenone
Purity
99.84%
Packaging
5mg
Price
$396
Updated
2021/12/16
ChemScene
Product number
CS-8044
Product name
Esaxerenone
Purity
99.84%
Packaging
10mg
Price
$600
Updated
2021/12/16
ChemScene
Product number
CS-8044
Product name
Esaxerenone
Purity
99.84%
Packaging
50mg
Price
$1800
Updated
2021/12/16
ChemScene
Product number
CS-8044
Product name
Esaxerenone
Purity
99.84%
Packaging
100mg
Price
$2520
Updated
2021/12/16
More
Less

Esaxerenone Chemical Properties,Usage,Production

Uses

Esaxerenone, is a novel, highly potent and selective non-steroidal mineralocorticoid receptor antagonist.

Biological Activity

Esaxerenone exerts its antihypertensive effect by blocking excessive activation of the mineralocorticoid receptor by endogenous ligands (such as aldosterone), has a mineralocorticoid receptor selectivity at least 1000-fold greater than other steroid hormone receptors, a long half-life, high oral bioavailability, and has a more significant antihypertensive effect than spironolactone or eplerenone.

Synthesis

below shows the synthesis route of Esaxerenone

in vivo

After single oral administration of Esaxerenone at 0.1, 0.3, 1, and 3mg/kg, maximum plasma concentration (Cmax) and the area under the plasma concentration versus time curve (AUC) are increased with dose. Time to reach the maximum plasma concentration (Tmax) of Esaxerenone ranges from 2.0 to 4.5h. After intravenous administration of Esaxerenone at 0.1, 0.3, 1, and 3mg/kg, the total body clearance (CL) and distribution volume at steady state (Vss) are 3.53 to 6.69mL/min/kg and 1.47 to 2.49L/kg, respectively, in rats, and 2.79 to 3.69mL/min/kg and 1.34 to 1.54L/kg, respectively, in cynomolgus monkeys. Up to 168h after administration, 3.9% and 91.4% of dosed radioactivity are excreted in rat urine and feces, respectively, and 95.2% in total. In monkeys, the excreted radioactivity up to 168h is 11.5% in urine, 82.3% in feces, and 93.9% in total[1].

Esaxerenone Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Esaxerenone Suppliers

China 67 India 1 United States 5 USA 1 Global 74
Nanjing Vcare PharmaTech Co., Ltd
Tel
025-58741518 13327700685
Email
sales@vcarepharmatech.com
Country
China
ProdList
487
Advantage
58
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
Tel
17702719238 18971495150;
Email
sales@sun-shinechem.com
Country
China
ProdList
1136
Advantage
64
Shanghai Famo Bio-chemical Technology Company Ltd.
Tel
021-36680027 15821745250
Email
fengqiang@famobiotech.com
Country
China
ProdList
485
Advantage
56
Valiant Co., Ltd.
Tel
0535-6101880
Fax
0535-6386989
Email
liutao@valiant-cn.com
Country
China
ProdList
286
Advantage
60
Bide Pharmatech Ltd.
Tel
400-400-164-7117 18317119277
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
40000
Advantage
60
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4817
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
86249
Advantage
60
Shanghai Biopharmaleader Co., Ltd.
Tel
+86 18721201413
Fax
+86 (21) 5775-8967
Email
sales@biopharmaleader.com
Country
China
ProdList
1720
Advantage
58
Wuhan Sun-shine Bio-technology Corporation Limited
Tel
+86-027-6552-2453
Email
sales@sun-shinechem.com
Country
China
ProdList
727
Advantage
58
Niuruisi Medical Technology Co. Ltd.
Tel
13872091715
Email
cheng1297@126.com
Country
China
ProdList
282
Advantage
58
More
Less

View Lastest Price from Esaxerenone manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
Esaxerenone 1632006-28-0
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kg
Release date
2025-06-07

1632006-28-0, EsaxerenoneRelated Search:


  • cs3150
  • cs-3150
  • Esaxerenone
  • CS-3150 (Esaxerenone
  • XL-550)
  • CS-2614
  • 5G,100G,500G
  • CS-3150; CS 3150; CS3150; XL-550; XL550; XL 550.
  • 1H-Pyrrole-3-carboxamide, 1-(2-hydroxyethyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-5-[2-(trifluoromethyl)phenyl]-, (5S)-
  • 1-(2-hydroxyethyl)-4-methyl-N-(4-methylsulfonylphenyl)-5-[2-(trifluoromethyl)phenyl]pyrrole-3-carboxamide
  • Esaxerenone(CS-3150)
  • Esaxerenone,Inhibitor,Mineralocorticoid Receptor,CS 3150,CS3150,inhibit,XL550,XL 550
  • 1-(2-Hydroxyethyl)-4-methyl-N-(4-(methylsulfonyl)phenyl)-5-(2-(trifluoromethyl)phenyl)-1H-pyrrole-3-carboxamide
  • Esaxerenone, 10 mM in DMSO
  • 1-(2-Hydroxyethyl)-4-methyl-N-(4-(methylsulfonyl)phenyl)-5-(2-(trifluoromethyl)phenyl)-1H-pyrrole-3-carboxamide , Esaxerenone
  • (5P)-1-(2-Hydroxyethyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-5-[2- (trifluoromethyl) phenyl]-1H-pyrrole-3-carboxamide
  • RMA-888
  • ESAXERENONE WS
  • 1632006-28-0