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Esaxerenone

Product Name
Esaxerenone
CAS No.
1632006-28-0
Chemical Name
Esaxerenone
Synonyms
cs3150;cs-3150;CS-2614;XL-550);Esaxerenone;5G,100G,500G;Esaxerenone(CS-3150);CS-3150 (Esaxerenone;Esaxerenone, 10 mM in DMSO;CS-3150; CS 3150; CS3150; XL-550; XL550; XL 550.
CBNumber
CB33159937
Molecular Formula
C22H21F3N2O4S
Formula Weight
466.48
MOL File
1632006-28-0.mol
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Esaxerenone Property

Boiling point:
581.3±50.0 °C(Predicted)
Density 
1.35±0.1 g/cm3(Predicted)
solubility 
DMSO:100.0(Max Conc. mg/mL);214.37(Max Conc. mM)
pka
12.76±0.70(Predicted)
form 
Solid
color 
White to light yellow
InChI
InChI=1S/C22H21F3N2O4S/c1-14-18(21(29)26-15-7-9-16(10-8-15)32(2,30)31)13-27(11-12-28)20(14)17-5-3-4-6-19(17)22(23,24)25/h3-10,13,28H,11-12H2,1-2H3,(H,26,29)
InChIKey
NOSNHVJANRODGR-UHFFFAOYSA-N
SMILES
C(N1C=C(C(=O)NC2C=CC(S(=O)(=O)C)=CC=2)C(C)=C1C1C=CC=CC=1C(F)(F)F)CO
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
E888295
Product name
Esaxerenone
Packaging
10mg
Price
$270
Updated
2021/12/16
ChemScene
Product number
CS-8044
Product name
Esaxerenone
Purity
99.84%
Packaging
5mg
Price
$396
Updated
2021/12/16
ChemScene
Product number
CS-8044
Product name
Esaxerenone
Purity
99.84%
Packaging
10mg
Price
$600
Updated
2021/12/16
ChemScene
Product number
CS-8044
Product name
Esaxerenone
Purity
99.84%
Packaging
50mg
Price
$1800
Updated
2021/12/16
ChemScene
Product number
CS-8044
Product name
Esaxerenone
Purity
99.84%
Packaging
100mg
Price
$2520
Updated
2021/12/16
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Esaxerenone Chemical Properties,Usage,Production

Uses

Esaxerenone, is a novel, highly potent and selective non-steroidal mineralocorticoid receptor antagonist.

Biological Activity

Esaxerenone exerts its antihypertensive effect by blocking excessive activation of the mineralocorticoid receptor by endogenous ligands (such as aldosterone), has a mineralocorticoid receptor selectivity at least 1000-fold greater than other steroid hormone receptors, a long half-life, high oral bioavailability, and has a more significant antihypertensive effect than spironolactone or eplerenone.

Synthesis

below shows the synthesis route of Esaxerenone

in vivo

After single oral administration of Esaxerenone at 0.1, 0.3, 1, and 3?mg/kg, maximum plasma concentration (Cmax) and the area under the plasma concentration versus time curve (AUC) are increased with dose. Time to reach the maximum plasma concentration (Tmax) of Esaxerenone ranges from 2.0 to 4.5?h. After intravenous administration of Esaxerenone at 0.1, 0.3, 1, and 3?mg/kg, the total body clearance (CL) and distribution volume at steady state (Vss) are 3.53 to 6.69?mL/min/kg and 1.47 to 2.49?L/kg, respectively, in rats, and 2.79 to 3.69?mL/min/kg and 1.34 to 1.54?L/kg, respectively, in cynomolgus monkeys. Up to 168?h after administration, 3.9% and 91.4% of dosed radioactivity are excreted in rat urine and feces, respectively, and 95.2% in total. In monkeys, the excreted radioactivity up to 168?h is 11.5% in urine, 82.3% in feces, and 93.9% in total[1].

Esaxerenone Preparation Products And Raw materials

Raw materials

Preparation Products

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Esaxerenone Suppliers

China 65 India 1 United States 5 USA 1 Global 72
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52923
Advantage
58
ChemShuttle. Inc.
Tel
--
Fax
--
Email
Sales@ChemShuttle.com
Country
United States
ProdList
6695
Advantage
58
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View Lastest Price from Esaxerenone manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
Esaxerenone 1632006-28-0
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kg
Release date
2025-06-07

1632006-28-0, EsaxerenoneRelated Search:


  • cs3150
  • cs-3150
  • Esaxerenone
  • CS-3150 (Esaxerenone
  • XL-550)
  • CS-2614
  • 5G,100G,500G
  • CS-3150; CS 3150; CS3150; XL-550; XL550; XL 550.
  • 1H-Pyrrole-3-carboxamide, 1-(2-hydroxyethyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-5-[2-(trifluoromethyl)phenyl]-, (5S)-
  • 1-(2-hydroxyethyl)-4-methyl-N-(4-methylsulfonylphenyl)-5-[2-(trifluoromethyl)phenyl]pyrrole-3-carboxamide
  • Esaxerenone(CS-3150)
  • Esaxerenone,Inhibitor,Mineralocorticoid Receptor,CS 3150,CS3150,inhibit,XL550,XL 550
  • 1-(2-Hydroxyethyl)-4-methyl-N-(4-(methylsulfonyl)phenyl)-5-(2-(trifluoromethyl)phenyl)-1H-pyrrole-3-carboxamide
  • Esaxerenone, 10 mM in DMSO
  • 1-(2-Hydroxyethyl)-4-methyl-N-(4-(methylsulfonyl)phenyl)-5-(2-(trifluoromethyl)phenyl)-1H-pyrrole-3-carboxamide , Esaxerenone
  • (5P)-1-(2-Hydroxyethyl)-4-methyl-N-[4-(methylsulfonyl)phenyl]-5-[2- (trifluoromethyl) phenyl]-1H-pyrrole-3-carboxamide
  • 1632006-28-0