KR-33494
- Product Name
- KR-33494
- CAS No.
- 1021497-97-1
- Chemical Name
- KR-33494
- Synonyms
- KM-819;CS-2472;KR-33494;KR-33493;KR-33494 ，E2361;KR33494;KR 33494;KR-33493, 10 mM in DMSO;4-(2-(4-bromophenylthio)acetamido)-1-phenethyl-1H-pyrazole-3-carboxylic acid;4-[2-(4-bromo-phenylsulfanyl)-acetylamino]-1-phenethyl-1H-pyrazole-3-carboxylic acid;4-[[2-[(4-Bromophenyl)thio]acetyl]amino]-1-(2-phenylethyl)-1H-pyrazole-3-carboxylic acid
- CBNumber
- CB33164788
- Molecular Formula
- C20H18BrN3O3S
- Formula Weight
- 460.34
- MOL File
- 1021497-97-1.mol
KR-33494 Property
- storage temp.
- Store at -20°C
- solubility
- DMSO:61.5(Max Conc. mg/mL);133.6(Max Conc. mM)
- form
- A crystalline solid
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 22071
- Product name
- KR-33494
- Packaging
- 1mg
- Price
- $97
- Updated
- 2024/03/01
- Product number
- 22071
- Product name
- KR-33494
- Packaging
- 5mg
- Price
- $410
- Updated
- 2024/03/01
- Product number
- 22071
- Product name
- KR-33494
- Packaging
- 10mg
- Price
- $721
- Updated
- 2024/03/01
- Product number
- 22071
- Product name
- KR-33494
- Packaging
- 25mg
- Price
- $1199
- Updated
- 2024/03/01
- Product number
- 2477DC
- Product name
- 4-[[2-(4-Bromophenyl)sulfanylacetyl]amino]-1-(2-phenylethyl)pyrazole-3-carboxylicacid
- Packaging
- 1mg
- Price
- $206
- Updated
- 2021/12/16
KR-33494 Chemical Properties,Usage,Production
Uses
KR-33493 is a potent inhibitor of Fas-mediated cell death (FAF1).
in vivo
Body weight changes of both sexes are not related to KR-33493 in all doses. In rats administrated KR-33493 for 4 weeks, no test article-related changes in any treated groups of either sex are found in hematology, serum biochemistry, and urinalysis. In dogs administrated KR-33493 for 2 weeks, red blood cell count (RBC) value in males is significantly higher at the 1000 mg/kg/day dose than that of the control group (i.e., 6.96±0.323 vs. 6.12±0.418). However, the change of RBC is recovered after the end of the administration period. The dose-normalized AUClast is not significantly different between the groups, suggesting that KR-33493 is governed by linear kinetics[1].
IC 50
Fas
References
[1] Jeong JW, et al. Subacute toxicity evaluation of KR-33493, FAF1 inhibitor for a new anti-parkinson's disease agent, after oral administration in rats and dogs. Regul Toxicol Pharmacol. 2016 Nov;81:387-396. DOI:10.1016/j.yrtph.2016.09.022
KR-33494 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from KR-33494 manufacturers
- Product
- KR-33494 1021497-97-1
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2021-09-13
- Product
- KR-33494 1021497-97-1
- Price
- US $100.00/Kg/Bag
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10kg
- Release date
- 2021-09-15
- Product
- KR-33494 1021497-97-1
- Price
- US $0.00/gram
- Min. Order
- 1gram
- Purity
- 99%
- Supply Ability
- 10kg
- Release date
- 2022-02-17