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TNU9056

Product Name
TNU9056
CAS No.
1450644-28-6
Chemical Name
TNU9056
Synonyms
TNU9056;Isothiazole, 5,5'-dithiobis-;NU 9056, KAT5 (Tip60) inhibitor;1,2-Di(isothiazol-5-yl)disulfane;NU9056 1,2-Bis(isothiazol-5-yl)disulfane;TNU9056 1,2-Di(isothiazol-5-yl)disulfane;5-(1,2-thiazol-5-yldisulfanyl)-1,2-thiazole
CBNumber
CB33165811
Molecular Formula
C6H4N2S4
Formula Weight
232.37
MOL File
1450644-28-6.mol
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TNU9056 Property

Boiling point:
209.2±40.0 °C(Predicted)
Density 
1.60±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
<10mg/ml in DMSO
form 
Liquid
pka
2.44±0.38(Predicted)
color 
Yellow to brown
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
5.00511
Product name
Histone Acetyltransferase Inhibitor VIII, NU9056
Packaging
10 mg
Price
$259
Updated
2025/07/31
TRC
Product number
N925310
Product name
NU9056
Packaging
5mg
Price
$70
Updated
2021/12/16
ApexBio Technology
Product number
A4492
Product name
1,2-di(isothiazol-5-yl)disulfane
Packaging
10mg
Price
$223
Updated
2021/12/16
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TNU9056 Chemical Properties,Usage,Production

Uses

NU 9056 is a selective KAT5 (Tip60) histone acetyltransferase inhibitor. It inhibits protein acetylation in prostate cancer cell lines and blocks DNA damage response. Iy decreases proliferation of LNCaP cells and induces apoptosis via caspase activation.

Biological Activity

Cell permeable: yes', 'Primary Target
KAT5', 'Reversible: yes

in vivo

The mice are injected with Nu9056 (2 μg/g) and the hippocampus is collected 1 h later. Tip60 inhibition reduces H2A.Z binding at the -1 nucleosome of Arc, and the +1 nucleosome of Arc and Syp. Additionally, Nu9056 increases acetylation at the -1 nucleosome of Fos, Tacstd2, and Gria4, and the +1 nucleosome of Gria4[2].

storage

Store at -20°C

TNU9056 Preparation Products And Raw materials

Raw materials

Preparation Products

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TNU9056 Suppliers

China 35 United Kingdom 1 United States 3 USA 1 Global 40
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
15883
Advantage
64
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9658
Advantage
60
Beijing Yisiyan Technology Research Center
Tel
010-56645598 13366904824
Fax
01062230033
Email
bjkaida@163.com
Country
China
ProdList
1618
Advantage
59
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Nanjing Dulai Biotechnology Co., Ltd.
Tel
025-846993838003-8003 18013301590
Fax
025-84699383-8003
Email
njduly@126.com
Country
China
ProdList
3249
Advantage
55
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3506
Advantage
58
Yancheng Schiemann Biological Technology Co.,Ltd
Tel
515-88280676 18921872653
Email
sales@ximanbio.com
Country
China
ProdList
1524
Advantage
56
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62

1450644-28-6, TNU9056Related Search:


  • TNU9056
  • TNU9056 1,2-Di(isothiazol-5-yl)disulfane
  • 5-(1,2-thiazol-5-yldisulfanyl)-1,2-thiazole
  • 1,2-Di(isothiazol-5-yl)disulfane
  • Isothiazole, 5,5'-dithiobis-
  • NU9056 1,2-Bis(isothiazol-5-yl)disulfane
  • NU 9056, KAT5 (Tip60) inhibitor
  • 1450644-28-6