RIPA-56

Product Name: RIPA-56
CAS No.: 1956370-21-0
Chemical Name: RIPA-56
Synonyms: RIPA-56;RIPA56; RIPA 56;RIPA-56 >=98% (HPLC);N-Benzyl-N-hydroxy-2,2-dimethylbutanamide;Butanamide, N-hydroxy-2,2-dimethyl-N-(phenylmethyl)-;RIPA-56,inhibit,Receptor-interacting protein kinases,RIP kinase,RIPK,Inhibitor,RIPA 56,RIPA56
CBNumber: CB33167633
Molecular Formula: C13H19NO2
Formula Weight: 221.3
MOL File: 1956370-21-0.mol

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RIPA-56 Property

Boiling point:: 346.0±35.0 °C(Predicted)
Density: 1.070±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 50 mg/ml)
form: solid
pka: 9.42±0.50(Predicted)
color: White
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2100
Product name: RIPA-56
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $64.9
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML2100
Product name: RIPA-56
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $198
Updated: 2024/03/01

Axon Medchem

Product number: Axon2677
Product name: RIPA-56
Purity: 99%
Packaging: 50mg
Price: $132
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb546233
Product name: RIPA-56 ???
Purity: >98%
Packaging: 10mg
Price: $136
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb546233
Product name: RIPA-56 ???
Purity: >98%
Packaging: 50mg
Price: $307.7
Updated: 2021/12/16

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RIPA-56 Chemical Properties,Usage,Production

Description

RIPA-56 (1956370-21-0) is a potent (IC50?= 13 nM, EC50?= 28nM for HT-29 cells) and selective inhibitor of Receptor-Interacting Protein 1 (RIP1) kinase with significant metabolic stability (t1/2?= 128min human liver microsomal stability assay).? RIPA-56 showed excellent kinase selectivity and did not inhibit IDO at 200 μM.?It was able to block the progression of multiple sclerosis in an immune-induced demyelination model.2

Biochem/physiol Actions

RIPA-56 is a metabolically stable type III kinase inhibitor that targets receptor-interacting protein 1 kinase (RIP1; RIPK1) in a highly potent and selective manner (RIP1 IC50 = 13 nM) by locking RIP1 in its inactive form, exhibiting no inhibitory potency toward RIP3, IDO or a panel of multiple kinases (tested at 10, 200, and 5 μM, respectively). RIPA-56 protects against TNFα-induced necroptosis (necrosis) upon apoptosis/NF-κB pathway blockage (EC50?= 27 nM/murine L929 and 28 nM/human HT-29 cells) in cultures as well as TNFα-induced mortality and multiorgan damage in a murine model of systemic inflammatory response syndrome (SIRS) in vivo (100% survival rate with 3 mg/kg/12 h or single 6 mg/kg i.p.) with good pharmacokinetics and bioavailability (F post 10 mg/kg p.o. or i.p. dosing = 22% and 100%, respectively, of 2 mg/kg i.v.). Long-term daily RIPA-56 supplementation (150 or 300 mg/kg in chow) is reported to prevent aging-associated deterioration of the male reproductive system in mice.

storage

Store at -20°C

References

1) Ren?et al.?(2017),?Discovery of a Highly Potent, Selective, and Metabolically Stable Inhibitor of Receptor-Interacting Protein 1 (RIP1) for the Treatment of Systemic Inflammatory Response Syndrome; J. Med. Chem.?60?972

RIPA-56 Preparation Products And Raw materials

Raw materials

Preparation Products

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RIPA-56 Suppliers

China 49 United States 6 USA 1 Global 56

Shanghai JiYi Biotechnology Co. Ltd.

Tel: 13621943973
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Email: sales@shjiyipharmatech.com
Country: China
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Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4121
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Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
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ShangHai Biochempartner Co.,Ltd

Tel: 17754423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
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Shanghai Rechem science Co., Ltd.

Tel: 21-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
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Shanghai Chaolan Chemical Technology Center

Tel: QQ:65489617 15618227136
Fax: 21-5161 9052
Email: info@SuperLan-chem.com
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Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
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Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
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Email: psaitong@jm-bio.com
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Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9730
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InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
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1956370-21-0, RIPA-56Related Search:

ZM 336372 1,9-Pyrazoloanthrone 2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- SU 4312

RIPA56; RIPA 56

RIPA-56

Butanamide, N-hydroxy-2,2-dimethyl-N-(phenylmethyl)-

RIPA-56 >=98% (HPLC)

N-Benzyl-N-hydroxy-2,2-dimethylbutanamide

RIPA-56,inhibit,Receptor-interacting protein kinases,RIP kinase,RIPK,Inhibitor,RIPA 56,RIPA56

1956370-21-0