RIPA-56
- Product Name
- RIPA-56
- CAS No.
- 1956370-21-0
- Chemical Name
- RIPA-56
- Synonyms
- RIPA-56;RIPA56; RIPA 56;RIPA-56 >=98% (HPLC);RIPA-56, 10 mM in DMSO;RIPA-56/1956370-21-0/98%;N-Benzyl-N-hydroxy-2,2-dimethylbutanamide;Butanamide, N-hydroxy-2,2-dimethyl-N-(phenylmethyl)-;RIPA-56,inhibit,Receptor-interacting protein kinases,RIP kinase,RIPK,Inhibitor,RIPA 56,RIPA56
- CBNumber
- CB33167633
- Molecular Formula
- C13H19NO2
- Formula Weight
- 221.3
- MOL File
- 1956370-21-0.mol
RIPA-56 Property
- Boiling point:
- 346.0±35.0 °C(Predicted)
- Density
- 1.070±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 50 mg/ml)
- pka
- 9.42±0.50(Predicted)
- form
- solid
- color
- White
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
- InChI
- InChI=1S/C13H19NO2/c1-4-13(2,3)12(15)14(16)10-11-8-6-5-7-9-11/h5-9,16H,4,10H2,1-3H3
- InChIKey
- AVYVHIKSFXVDBG-UHFFFAOYSA-N
- SMILES
- C(N(O)CC1=CC=CC=C1)(=O)C(C)(C)CC
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- SML2100
- Product name
- RIPA-56
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $56.7
- Updated
- 2025/07/31
- Product number
- SML2100
- Product name
- RIPA-56
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $173
- Updated
- 2025/07/31
- Product number
- Axon2677
- Product name
- RIPA-56
- Purity
- 99%
- Packaging
- 50mg
- Price
- $132
- Updated
- 2021/12/16
- Product number
- orb546233
- Product name
- RIPA-56 ???
- Purity
- >98%
- Packaging
- 10mg
- Price
- $136
- Updated
- 2021/12/16
- Product number
- orb546233
- Product name
- RIPA-56 ???
- Purity
- >98%
- Packaging
- 50mg
- Price
- $307.7
- Updated
- 2021/12/16
RIPA-56 Chemical Properties,Usage,Production
Description
RIPA-56 (1956370-21-0) is a potent (IC50?= 13 nM, EC50?= 28nM for HT-29 cells) and selective inhibitor of Receptor-Interacting Protein 1 (RIP1) kinase with significant metabolic stability (t1/2?= 128min human liver microsomal stability assay).? RIPA-56 showed excellent kinase selectivity and did not inhibit IDO at 200 μM.?It was able to block the progression of multiple sclerosis in an immune-induced demyelination model.2
Uses
RIPA-56 is a highly potent, selective, and metabolically stable inhibitor of receptor-interacting protein 1 (RIP1) with an IC50 of 13 nM. RIPA-56 can be used for the treatment of systemic inflammatory response syndrome[1].
Biochem/physiol Actions
RIPA-56 is a metabolically stable type III kinase inhibitor that targets receptor-interacting protein 1 kinase (RIP1; RIPK1) in a highly potent and selective manner (RIP1 IC50 = 13 nM) by locking RIP1 in its inactive form, exhibiting no inhibitory potency toward RIP3, IDO or a panel of multiple kinases (tested at 10, 200, and 5 μM, respectively). RIPA-56 protects against TNFα-induced necroptosis (necrosis) upon apoptosis/NF-κB pathway blockage (EC50?= 27 nM/murine L929 and 28 nM/human HT-29 cells) in cultures as well as TNFα-induced mortality and multiorgan damage in a murine model of systemic inflammatory response syndrome (SIRS) in vivo (100% survival rate with 3 mg/kg/12 h or single 6 mg/kg i.p.) with good pharmacokinetics and bioavailability (F post 10 mg/kg p.o. or i.p. dosing = 22% and 100%, respectively, of 2 mg/kg i.v.). Long-term daily RIPA-56 supplementation (150 or 300 mg/kg in chow) is reported to prevent aging-associated deterioration of the male reproductive system in mice.
in vivo
In the SIRS mice disease model, RIPA-56 efficiently reduces tumor necrosis factor alpha (TNFα)-induced mortality and multi-organ damage. Compared to known RIP1 inhibitors, RIPA-56 is potent in both human and murine cells, is much more stable in vivo, and is efficacious in animal model studies. RIPA-56 has an impressive PK profile in mice with a 3.1 h half-life, 22% oral bioavailability (P.O.), and 100% bioavailability from intraperitoneal injection (I.P.)[1].
storage
Store at -20°C
References
[1] YAN REN. Discovery of a Highly Potent, Selective, and Metabolically Stable Inhibitor of Receptor-Interacting Protein 1 (RIP1) for the Treatment of Systemic Inflammatory Response Syndrome[J]. Journal of Medicinal Chemistry, 2016, 60 3: 972-986. DOI:10.1021/acs.jmedchem.6b01196
RIPA-56 Preparation Products And Raw materials
Raw materials
Preparation Products
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