RIPA-56

Product Name: RIPA-56
CAS No.: 1956370-21-0
Chemical Name: RIPA-56
Synonyms: RIPA-56;RIPA56; RIPA 56;RIPA-56 >=98% (HPLC);N-Benzyl-N-hydroxy-2,2-dimethylbutanamide;Butanamide, N-hydroxy-2,2-dimethyl-N-(phenylmethyl)-;RIPA-56,inhibit,Receptor-interacting protein kinases,RIP kinase,RIPK,Inhibitor,RIPA 56,RIPA56
CBNumber: CB33167633
Molecular Formula: C13H19NO2
Formula Weight: 221.3
MOL File: 1956370-21-0.mol

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RIPA-56 Property

Boiling point:: 346.0±35.0 °C(Predicted)
Density: 1.070±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 50 mg/ml)
form: solid
pka: 9.42±0.50(Predicted)
color: White
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2100
Product name: RIPA-56
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $64.9
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML2100
Product name: RIPA-56
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $198
Updated: 2024/03/01

Axon Medchem

Product number: Axon2677
Product name: RIPA-56
Purity: 99%
Packaging: 50mg
Price: $132
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb546233
Product name: RIPA-56 ???
Purity: >98%
Packaging: 10mg
Price: $136
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb546233
Product name: RIPA-56 ???
Purity: >98%
Packaging: 50mg
Price: $307.7
Updated: 2021/12/16

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RIPA-56 Chemical Properties,Usage,Production

Description

RIPA-56 (1956370-21-0) is a potent (IC50?= 13 nM, EC50?= 28nM for HT-29 cells) and selective inhibitor of Receptor-Interacting Protein 1 (RIP1) kinase with significant metabolic stability (t1/2?= 128min human liver microsomal stability assay).? RIPA-56 showed excellent kinase selectivity and did not inhibit IDO at 200 μM.?It was able to block the progression of multiple sclerosis in an immune-induced demyelination model.2

Biochem/physiol Actions

RIPA-56 is a metabolically stable type III kinase inhibitor that targets receptor-interacting protein 1 kinase (RIP1; RIPK1) in a highly potent and selective manner (RIP1 IC50 = 13 nM) by locking RIP1 in its inactive form, exhibiting no inhibitory potency toward RIP3, IDO or a panel of multiple kinases (tested at 10, 200, and 5 μM, respectively). RIPA-56 protects against TNFα-induced necroptosis (necrosis) upon apoptosis/NF-κB pathway blockage (EC50?= 27 nM/murine L929 and 28 nM/human HT-29 cells) in cultures as well as TNFα-induced mortality and multiorgan damage in a murine model of systemic inflammatory response syndrome (SIRS) in vivo (100% survival rate with 3 mg/kg/12 h or single 6 mg/kg i.p.) with good pharmacokinetics and bioavailability (F post 10 mg/kg p.o. or i.p. dosing = 22% and 100%, respectively, of 2 mg/kg i.v.). Long-term daily RIPA-56 supplementation (150 or 300 mg/kg in chow) is reported to prevent aging-associated deterioration of the male reproductive system in mice.

storage

Store at -20°C

References

1) Ren?et al.?(2017),?Discovery of a Highly Potent, Selective, and Metabolically Stable Inhibitor of Receptor-Interacting Protein 1 (RIP1) for the Treatment of Systemic Inflammatory Response Syndrome; J. Med. Chem.?60?972

RIPA-56 Preparation Products And Raw materials

Raw materials

Preparation Products

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RIPA-56 Suppliers

China 48 United States 7 USA 1 Global 56

Changsha Fuzhen Biotechnology Co.，LTD

Tel: 13823398779 18670069958
Email: 3062105966@qq.com
Country: China
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Shanghai JiYi Biotechnology Co. Ltd.

Tel: 13621943973
Fax: -
Email: sales@shjiyipharmatech.com
Country: China
ProdList: 1166
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Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4512
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Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
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ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
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Shanghai Rechem science Co., Ltd.

Tel: 21-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
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Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
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Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
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ProdList: 29785
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Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
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Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

1956370-21-0, RIPA-56Related Search:

ZM 336372 1,9-Pyrazoloanthrone 2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- SU 4312

RIPA56; RIPA 56

RIPA-56

Butanamide, N-hydroxy-2,2-dimethyl-N-(phenylmethyl)-

RIPA-56 >=98% (HPLC)

N-Benzyl-N-hydroxy-2,2-dimethylbutanamide

RIPA-56,inhibit,Receptor-interacting protein kinases,RIP kinase,RIPK,Inhibitor,RIPA 56,RIPA56

1956370-21-0