CC220

Product Name: CC220
CAS No.: 1323403-33-3
Chemical Name: CC220
Synonyms: CC220;CS-2470;Iberdomide;CC-220 Iberdomide;Iberdomide(CC220);CC220; CC 220; CC-220;Iberdomide, 10 mM in DMSO;Iberdomide (CC220) ，S8760;(S)-3-(4-((4-(Morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione;(S)-3-(4-((4-(Morpholin-4-ylmethyl)-benzyloxy))-1-oxoisoindolin-2-yl)piperidin-2,6-dione
CBNumber: CB33170516
Molecular Formula: C25H27N3O5
Formula Weight: 449.5
MOL File: 1323403-33-3.mol

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CC220 Property

Boiling point:: 717.8±60.0 °C(Predicted)
Density: 1.332±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:125.0(Max Conc. mg/mL);278.09(Max Conc. mM)
form: A crystalline solid
pka: 10.70±0.40(Predicted)
color: White to off-white
InChIKey: IXZOHGPZAQLIBH-NRFANRHFSA-N
SMILES: N1C(=O)CC[C@H](N2CC3=C(C2=O)C=CC=C3OCC2=CC=C(CN3CCOCC3)C=C2)C1=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22615
Product name: Iberdomide
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 22615
Product name: Iberdomide
Purity: ≥98%
Packaging: 5mg
Price: $139
Updated: 2024/03/01

Cayman Chemical

Product number: 22615
Product name: Iberdomide
Purity: ≥98%
Packaging: 10mg
Price: $243
Updated: 2024/03/01

Cayman Chemical

Product number: 22615
Product name: Iberdomide
Purity: ≥98%
Packaging: 25mg
Price: $533
Updated: 2024/03/01

AK Scientific

Product number: 4100DT
Product name: Iberdomide
Packaging: 5mg
Price: $252
Updated: 2021/12/16

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CC220 Chemical Properties,Usage,Production

Uses

Iberdomide (CC-220) is an orally active and potent cereblon (CRBN) E3 ligase modulator (CELMoD) with an IC50 of ~150?nM for cereblon-binding affinity. Iberdomide, a derivative of Thalidomide (HY-14658), has antitumor and immunostimulatory activities[1][2].

in vivo

Iberdomide (CC-220; 10 mg/kg; oral gavage) after 6 or 24 hours causes higher hCRBN expression in hC343 splenocytes correlated to deeper IKZF1/3 downregulation in WT (C57BL/6), hC123, or-343, (representing two different transgenic founder lines expressing hCRBN) and mCrbn^-/- mice^[2].

IC 50

Cereblon

References

[1] Chad C Bjorklund, et al. Iberdomide (CC-220) is a potent cereblon E3 ligase modulator with antitumor and immunostimulatory activities in lenalidomide- and pomalidomide-resistant multiple myeloma cells with dysregulated CRBN. Leukemia. 2020 Apr;34(4):1197-1201. DOI:10.1038/s41375-019-0620-8
[2] Erin W Meermeier, et al. Tumor burden limits bispecific antibody efficacy through T cell exhaustion averted by concurrent cytotoxic therapy. Blood Cancer Discov. 2021 Jul;2(4):354-369. DOI:10.1158/2643-3230.BCD-21-0038

CC220 Preparation Products And Raw materials

Raw materials

Preparation Products

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CC220 Suppliers

China 99 India 1 United States 5 USA 1 Global 106

Shanghai Jinyin Biological Technology Co., Ltd

Tel: 021-20986266 18019349802
Email: 814527417@qq.com
Country: China
ProdList: 461
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 16075
Advantage: 64

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4747
Advantage: 58

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9510
Advantage: 58

Changzhou Renaissance Chem Co. Ltd

Tel: 86-519-86202821
Fax: Email： sales@rosewellchem.com
Country: China
ProdList: 116
Advantage: 56

Hangzhou J&H Chemical Co., Ltd.

Tel: 0571-87396432
Fax: 0571-87396431
Email: sales@jhechem.com
Country: China
ProdList: 14912
Advantage: 59

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4769
Advantage: 55

Shanghai Send Pharmaceutical Technology Co., Ltd.

Tel: 021-58088081 Q2635253576
Fax: QQ3382968513
Email: hailey@shsendpharm.com
Country: China
ProdList: 2081
Advantage: 55

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View Lastest Price from CC220 manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: Iberdomide 1323403-33-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2021-09-13

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: Iberdomide 1323403-33-3
Price: US $100.00/Kg/Bag
Min. Order: 1KG
Purity: 99%
Supply Ability: 10kg
Release date: 2021-09-15

Career Henan Chemical Co

Product: CC220 1323403-33-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99.9%
Supply Ability: 100kg
Release date: 2019-12-26

1323403-33-3, CC220Related Search:

CC-220 Iberdomide

CC220

(S)-3-[4-(4-morpholin-4-yl-methyl-benzyloxy)-1-oxo-1,3-dihydro-isoindol-2-yl]-piperidine-2,6-dione

Iberdomide

Iberdomide(CC220)

CS-2470

CC220; CC 220; CC-220

2,6-Piperidinedione, 3-[1,3-dihydro-4-[[4-(4-morpholinylmethyl)phenyl]methoxy]-1-oxo-2H-isoindol-2-yl]-, (3S)-

(S)-3-(4-((4-(Morpholinomethyl)benzyl)oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

CELMoD,H929,CRBN,Ligands for E3 Ligase,KMS12PE,KMS11,orally,sub-G1,Apoptosis,Iberdomide,cereblon,G0/G1,U266,multiple,ligase,Inhibitor,Thalidomide,RPM-8226,MM1.R,MM1.S,CC220,EJM,KMS128M,CC 220,inhibit,E3 ligase-recruiting Moiety,myeloma

Iberdomide, 10 mM in DMSO

Iberdomide (CC220) ，S8760

(S)-3-(4-((4-(Morpholin-4-ylmethyl)-benzyloxy))-1-oxoisoindolin-2-yl)piperidin-2,6-dione

1323403-33-3