NVX-207
- Product Name
- NVX-207
- CAS No.
- 745020-66-0
- Chemical Name
- NVX-207
- Synonyms
- NVX-207;NVX 207,NVX207;Lup-20(29)-en-28-oic acid, 3-(acetyloxy)-, 2-amino-3-hydroxy-2-(hydroxymethyl)propyl ester, (3β)-
- CBNumber
- CB33175566
- Molecular Formula
- C36H59NO6
- Formula Weight
- 601.87
- MOL File
- 745020-66-0.mol
NVX-207 Property
- Boiling point:
- 664.8±55.0 °C(Predicted)
- Density
- 1.14±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 125 mg/mL (207.69 mM)
- pka
- 11.71±0.20(Predicted)
- form
- Solid
- color
- White to off-white
NVX-207 Chemical Properties,Usage,Production
Uses
NVX-207, a Betulinic acid-derived anti-cancer compound, shows anti-tumor activity (mean IC50=3.5 μM) against various human and canine cell lines. NVX-207-induced apoptosis is associated with activation of the intrinsic apoptotic pathway via cleavage of caspases -9, -3, -7 and of PARP[1].
in vivo
Intravenous application of NVX-207 in mice is well tolerated[1].
References
[1] Willmann M, et al. Characterization of NVX-207, a novel betulinic acid-derived anti-cancer compound. Eur J Clin Invest. 2009;39(5):384-394. DOI:10.1111/j.1365-2362.2009.02105.x
[2] Bache M, et al. Betulinic acid derivatives NVX-207 and B10 for treatment of glioblastoma--an in vitro study of cytotoxicity and radiosensitization. Int J Mol Sci. 2014 Oct 30;15(11):19777-90. DOI:10.3390/ijms151119777
NVX-207 Preparation Products And Raw materials
Raw materials
Preparation Products
NVX-207 Suppliers
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- +1-781-999-5354; +17819995354
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- United States
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