ChemicalBook > CAS DataBase List > 2-(2,6-Dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione

2-(2,6-Dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione

Product Name
2-(2,6-Dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione
CAS No.
835616-61-0
Chemical Name
2-(2,6-Dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione
Synonyms
2-(2,6-dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5-fluoroisoindole-1,3-dione;Thalidomide 5-fluoride;2-(2,6-dioxopiperidin-3-yl)-5-fluoro-2,3-dihydro-1H-isoindole-1,3-dione;135588;Thali-5F;Light purple to off white powder;2-(2,6-dioxo-3-piperidyl)-5-fluoro-isoindoline-1,3-dione;2-(2,6-Dioxo-3-piperidinyl)-5-fluoro-1,3-isoindolinedione;? 2-(2,6-Dioxopiperidin-3-yl)-5- difluoroisoindoline-1,3-dione
CBNumber
CB33266857
Molecular Formula
C13H9FN2O4
Formula Weight
276.22
MOL File
835616-61-0.mol
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2-(2,6-Dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione Property

Boiling point:
521.5±45.0 °C(Predicted)
Density 
1.570±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO: 83.33 mg/mL (301.68 mM)
pka
10.65±0.40(Predicted)
form 
Solid
color 
Off-white to gray
InChI
InChI=1S/C13H9FN2O4/c14-6-1-2-7-8(5-6)13(20)16(12(7)19)9-3-4-10(17)15-11(9)18/h1-2,5,9H,3-4H2,(H,15,17,18)
InChIKey
MPQLCQKBYRSPNA-UHFFFAOYSA-N
SMILES
C1(=O)C2=C(C=C(F)C=C2)C(=O)N1C1CCC(=O)NC1=O
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P310Immediately call a POISON CENTER or doctor/physician.

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Ambeed
Product number
A1004509
Product name
2-(2,6-Dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione
Purity
97%
Packaging
250mg
Price
$35
Updated
2021/12/16
Ambeed
Product number
A1004509
Product name
2-(2,6-Dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione
Purity
97%
Packaging
1g
Price
$70
Updated
2021/12/16
Ambeed
Product number
A1004509
Product name
2-(2,6-Dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione
Purity
97%
Packaging
5g
Price
$220
Updated
2021/12/16
Ambeed
Product number
A1004509
Product name
2-(2,6-Dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione
Purity
97%
Packaging
10g
Price
$300
Updated
2021/12/16
Acrotein
Product number
H-7889
Product name
2-(2,6-Dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione
Purity
97%
Packaging
10g
Price
$348.33
Updated
2021/12/16
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2-(2,6-Dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione Chemical Properties,Usage,Production

Description

2-(2,6-dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione is a thalidomide analog that can be useful in PROTAC research.

Uses

Thalidomide 5'- fluoro (2-(2,6-Dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione) is a derivative of Thalidomide, commonly used as a precursor to PROTAC® Degraders that hijacks cereblon as the E3 ubiquitin ligase component. Supplied with a fluoro functional handle at a position known not to significantly affect binding to cereblon, ready for conjugation to a linker/target protein ligand.

storage

Store at +4°C

2-(2,6-Dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(2,6-Dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione Suppliers

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View Lastest Price from 2-(2,6-Dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
2-(2,6-dioxopiperidin-3-yl)-5-fluoroisoindole-1,3-dione 835616-61-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-18

835616-61-0, 2-(2,6-Dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dioneRelated Search:


  • 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-fluoro-
  • 2-(2,6-dioxopiperidin-3-yl)-5-fluoroisoindoline-1,3-dione
  • 135588
  • 2-(2,6-Dioxo-3-piperidinyl)-5-fluoro-1H-isoindole-1,3(2H)-dione
  • 2-(2,6-dioxopiperidin-3-yl)-5-fluoroisoindole-1,3-dione
  • ? 2-(2,6-Dioxopiperidin-3-yl)-5- difluoroisoindoline-1,3-dione
  • Thalidomide 5-fluoride
  • Light purple to off white powder
  • 2-(2,6-dioxopiperidin-3-yl)-5-fluoro-2,3-dihydro-1H-isoindole-1,3-dione
  • 2-(2,6-Dioxo-3-piperidinyl)-5-fluoro-1,3-isoindolinedione
  • 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-fl...
  • H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-fluoro-
  • 2-(2,6-dioxo-3-piperidyl)-5-fluoro-isoindoline-1,3-dione
  • Thali-5F
  • 835616-61-0
  • pharmaceutical