2-fluoro-4-(2-methyl-8-((3-(methylsulfonyl)benzyl)amino)imidazo[1,2-a]pyrazin-3-yl)phenol

Product Name: 2-fluoro-4-(2-methyl-8-((3-(methylsulfonyl)benzyl)amino)imidazo[1,2-a]pyrazin-3-yl)phenol
CAS No.: 1436383-95-7
Chemical Name: 2-fluoro-4-(2-methyl-8-((3-(methylsulfonyl)benzyl)amino)imidazo[1,2-a]pyrazin-3-yl)phenol
Synonyms: BF738735;BF738735 (BF 738735;BF738735, 10 mM in DMSO;PI4KIIIβ Inhibitor, BF738735;2-Fluoro-4-[2-methyl-8-[[3-(methylsulfonyl)benzyl]amino]-3-imidazo[1,2-a]pyrazinyl]phenol;2-fluoro-4-(2-methyl-8-((3-(methylsulfonyl)benzyl)amino)imidazo[1,2-a]pyrazin-3-yl)phenol;Phenol, 2-fluoro-4-[2-methyl-8-[[[3-(methylsulfonyl)phenyl]methyl]amino]imidazo[1,2-a]pyrazin-3-yl]-;BF738735,Phosphatidylinositol 4 kinases,Inhibitor,BF 738735,PI4 kinases,inhibit,BF-738735,Reverse Transcriptase,PI4K
CBNumber: CB33303776
Molecular Formula: C21H19FN4O3S
Formula Weight: 426.46
MOL File: 1436383-95-7.mol

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2-fluoro-4-(2-methyl-8-((3-(methylsulfonyl)benzyl)amino)imidazo[1,2-a]pyrazin-3-yl)phenol Property

Density: 1.42±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 125 mg/mL (293.11 mM)
pka: 8.08±0.20(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 5.33657
Product name: PI4KIIIβ Inhibitor, BF738735
Packaging: 10 mg
Price: $203
Updated: 2025/07/31

Tocris

Product number: 6246
Product name: BF738735
Purity: ≥98%(HPLC)
Packaging: 10
Price: $180
Updated: 2021/12/16

ChemScene

Product number: CS-0035356
Product name: BF738735
Purity: 99.10%
Packaging: 10mg
Price: $190
Updated: 2021/12/16

ChemScene

Product number: CS-0035356
Product name: BF738735
Purity: 99.10%
Packaging: 25mg
Price: $410
Updated: 2021/12/16

ChemScene

Product number: CS-0035356
Product name: BF738735
Purity: 99.10%
Packaging: 5mg
Price: $110
Updated: 2021/12/16

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2-fluoro-4-(2-methyl-8-((3-(methylsulfonyl)benzyl)amino)imidazo[1,2-a]pyrazin-3-yl)phenol Chemical Properties,Usage,Production

Uses

BF738735 is a phosphatidylinositol 4-kinase III beta (PI4KIIIβ) inhibitor with an IC50 of 5.7 nM.

Biological Activity

Cell permeable: yes', 'Primary Target
PI4KIII&beta', 'Reversible: yes

in vivo

BF738735 is well tolerated by specimens with good plasma levels of the antiviral in circulation and a complete inhibition with 25 mg/kg and some inhibition with 5 mg/kg dose is observed^[2].

IC 50

PI4KIIIβ: 5.7 nM (IC₅₀); PI4KIIIα: 1.7 μM (IC₅₀)

storage

Store at -20°C

References

[1] van der Schaar HM, et al. A novel, broad-spectrum inhibitor of enterovirus replication that targets host cell factor phosphatidylinositol 4-kinase IIIβ. Antimicrob Agents Chemother. 2013 Oct;57(10):4971-81. DOI:10.1128/AAC.01175-13
[2] V Saarnio. Antiviral Molecules of Enteroviruses. 13.1.2017.

2-fluoro-4-(2-methyl-8-((3-(methylsulfonyl)benzyl)amino)imidazo[1,2-a]pyrazin-3-yl)phenol Preparation Products And Raw materials

Raw materials

Preparation Products

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2-fluoro-4-(2-methyl-8-((3-(methylsulfonyl)benzyl)amino)imidazo[1,2-a]pyrazin-3-yl)phenol Suppliers

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1436383-95-7, 2-fluoro-4-(2-methyl-8-((3-(methylsulfonyl)benzyl)amino)imidazo[1,2-a]pyrazin-3-yl)phenolRelated Search:

2-fluoro-4-(2-methyl-8-((3-(methylsulfonyl)benzyl)amino)imidazo[1,2-a]pyrazin-3-yl)phenol

BF738735

BF738735 (BF 738735

Phenol, 2-fluoro-4-[2-methyl-8-[[[3-(methylsulfonyl)phenyl]methyl]amino]imidazo[1,2-a]pyrazin-3-yl]-

BF738735,Phosphatidylinositol 4 kinases,Inhibitor,BF 738735,PI4 kinases,inhibit,BF-738735,Reverse Transcriptase,PI4K

2-Fluoro-4-[2-methyl-8-[[3-(methylsulfonyl)benzyl]amino]-3-imidazo[1,2-a]pyrazinyl]phenol

BF738735, 10 mM in DMSO

PI4KIIIβ Inhibitor, BF738735

1436383-95-7