GSK9311

Product Name: GSK9311
CAS No.: 1923851-49-3
Chemical Name: GSK9311
Synonyms: GSK9311;GSK 9311;GSK-9311;GSK9311 >=98% (HPLC);GSK 9311 hydrochloride;BRPF1 bromodomain inhibitor GS9311;Benzamide, N-[2,3-dihydro-1,3-dimethyl-6-[(2R)-2-methyl-1-piperazinyl]-2-oxo-1H-benzimidazol-5-yl]-N-ethyl-2-methoxy-
CBNumber: CB33309536
Molecular Formula: C24H31N5O3
Formula Weight: 437.53
MOL File: 1923851-49-3.mol

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GSK9311 Property

Boiling point:: 625.5±55.0 °C(Predicted)
Density: 1.204±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : ≥ 30 mg/mL (68.57 mM)
pka: 8.82±0.40(Predicted)
form: Solid
color: White to off-white
optical activity: [α]/D 90 to 100°, c =0.3 in methanol

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1984
Product name: GSK9311
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $95.07
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1984
Product name: GSK9311
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $423
Updated: 2022/05/15

Tocris

Product number: 6203
Product name: GSK9311hydrochloride
Purity: ≥98%(HPLC)
Packaging: 25
Price: $279
Updated: 2021/12/16

Tocris

Product number: 6203
Product name: GSK9311hydrochloride
Purity: ≥98%(HPLC)
Packaging: 5
Price: $72
Updated: 2021/12/16

ChemScene

Product number: CS-6907
Product name: GSK9311
Purity: 99.23%
Packaging: 5mg
Price: $90
Updated: 2021/12/16

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GSK9311 Chemical Properties,Usage,Production

Uses

GSK9311, a less active analogue of GSK6853, can be used as a negative control. GSK9311 inhibits BRPF bromodomain with pIC50 values of 6.0 and 4.3 for BRPF1 and BRPF2, respectively[1].

Biological Activity

GSK9311 is a negative control for the SGC epigenetic probe GSK6853. GSK9311 exhibits 125- and 185-fold reduced potency than its structural analog GSK6853 toward BRPF1 in cell-free and cell-based assays (pIC50 = 6.0/GSK9311 vs. 8.1/GSK6853 in ligand competition binding assay by TR-FRET; IC50 = 3.7 μM/GSK9311 vs. 20 nM/GSK6853 against NanoLuc-BRPF1 bromodomain interaction with Histone H3.3-HaloTag in HEK293 cells), and therefore serves as a good inactive control compound in BRPF1 inhibition studies employing GSK6853. For characterization details of the active probe, GSK6853, please visit the GSK6853 probe summary on the Structural Genomics Consortium (SGC) website.

GSK6853, the active probe, is available from Sigma. To learn more about and purchase GSK6853, click here.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

IC 50

BRPF1: 6.0 (pIC₅₀); BRPF2: 4.3 (pIC₅₀)

References

[1] Bamborough P, et al. GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain. ACS Med Chem Lett. 2016 May 9;7(6):552-7. DOI:10.1021/acsmedchemlett.6b00092

GSK9311 Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK9311 Suppliers

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1923851-49-3, GSK9311Related Search:

GSK9311

GSK 9311;GSK-9311

BRPF1 bromodomain inhibitor GS9311

GSK 9311 hydrochloride

Benzamide, N-[2,3-dihydro-1,3-dimethyl-6-[(2R)-2-methyl-1-piperazinyl]-2-oxo-1H-benzimidazol-5-yl]-N-ethyl-2-methoxy-

GSK9311 >=98% (HPLC)

1923851-49-3