1-(2-ETHYLPHENOXY)-3-[[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL]AMINO]-(2S)-2-PROPANOL HYDROCHLORIDE

Product Name: 1-(2-ETHYLPHENOXY)-3-[[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL]AMINO]-(2S)-2-PROPANOL HYDROCHLORIDE
CAS No.: 174689-39-5
Chemical Name: 1-(2-ETHYLPHENOXY)-3-[[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL]AMINO]-(2S)-2-PROPANOL HYDROCHLORIDE
Synonyms: SR 59230A;SR59230AHCl;SR 59230A HYDROCHLORIDE;SR 59230A >=98% (HPLC), powder;(2S)-1-(2-ethylphenoxy)-3-{[(1S)-1,2,3,4-tetrahydronaphthalen-1-yl]amino}propan-2-ol;3-(2-ETHYLPHENOXY)-1-((1S)-1,2,3,4-TETRA-HYDRONAPHTH-1-YLAMINO)-(2S)-2-PROPANOL OXALATE;(S)-1-(2-Ethylphenoxy)-3-(((S)-1,2,3,4-tetrahydronaphthalen-1-yl)amino)propan-2-ol oxalate;3-(2-Ethylphenoxy)-1-[[(1S)-1,2,3,4-tetrahydronaphth-1-yl]amino]-(2S)-2-propanol oxalate salt;1-(2-ETHYLPHENOXY)-3-[[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL]AMINO]-(2S)-2-PROPANOL HYDROCHLORIDE;hyperthermia,adrenoceptor,Adrenergic Receptor,adrenergic,Beta Receptor,inhibit,hypothermia,receptor,Inhibitor,SR59230A,SR-59230A
CBNumber: CB3331761
Molecular Formula: C23H29NO6
Formula Weight: 415.49
MOL File: 174689-39-5.mol

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1-(2-ETHYLPHENOXY)-3-[[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL]AMINO]-(2S)-2-PROPANOL HYDROCHLORIDE Property

storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO: >10mg/mL
form: powder
color: white

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Safety

Safety Statements: 22-24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S8688
Product name: SR 59230A
Purity: ≥98% (HPLC), powder
Packaging: 5mg
Price: $165
Updated: 2024/03/01

Sigma-Aldrich

Product number: S8688
Product name: SR 59230A
Purity: ≥98% (HPLC), powder
Packaging: 25mg
Price: $228.4
Updated: 2024/03/01

Tocris

Product number: 1511
Product name: SR59230Ahydrochloride
Purity: ≥98%(HPLC)
Packaging: 10
Price: $220
Updated: 2021/12/16

Tocris

Product number: 1511
Product name: SR59230Ahydrochloride
Purity: ≥98%(HPLC)
Packaging: 50
Price: $926
Updated: 2021/12/16

Usbiological

Product number: 256751
Product name: SR 59230A hydrochloride
Packaging: 10mg
Price: $466
Updated: 2021/12/16

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1-(2-ETHYLPHENOXY)-3-[[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL]AMINO]-(2S)-2-PROPANOL HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

SR 59230A was used in the identification of β-adrenoceptors in rat aorta.³ It was tested as a potential therapeutic agent in improving cardiac function in rat model of heart failure.⁴

Hazard

A poison.

Biological Activity

Potent and selective β 3 adrenoceptor antagonist (IC 50 values are 40, 408 and 648 nM for β 3 , β 1 and β 2 receptors respectively). Orally active in vivo . Also available as part of the β -Adrenoceptor Antagonist Tocriset™ .

Biochem/physiol Actions

SR 59230A is a β3-adrenoceptor antagonist. It has high affinity for the β3 adrenoceptors occurring in human gut that affect the function of human colonic circular smooth muscle.1 It is reported that SR 59230A inhibits the Kir2.1-2.3 cardiac potassium channels.2

1-(2-ETHYLPHENOXY)-3-[[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL]AMINO]-(2S)-2-PROPANOL HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(2-ETHYLPHENOXY)-3-[[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL]AMINO]-(2S)-2-PROPANOL HYDROCHLORIDE Suppliers

China 45 Europe 1 Germany 3 Switzerland 1 United Kingdom 1 United States 6 Global 57

3B Pharmachem (Wuhan) International Co.,Ltd.

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Sigma-Aldrich

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Amadis Chemical Company Limited

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Aikon International Limited

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174689-39-5, 1-(2-ETHYLPHENOXY)-3-[[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL]AMINO]-(2S)-2-PROPANOL HYDROCHLORIDERelated Search:

(S)-N-METHYL-1,2,3,4-TETRAHYDRONAPHTHALEN-1-AMINE (S)--1-AMINOTETRALINE HCL 1-(2-ETHYLPHENOXY)-3-[[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL]AMINO]-(2S)-2-PROPANOL HYDROCHLORIDE (S)-(-)-1-BENZYLAMINO-3-PHENOXY-2-PROPANOL

3-(2-ETHYLPHENOXY)-1-((1S)-1,2,3,4-TETRA-HYDRONAPHTH-1-YLAMINO)-(2S)-2-PROPANOL OXALATE

SR 59230A HYDROCHLORIDE

SR59230AHCl

3-(2-Ethylphenoxy)-1-[[(1S)-1,2,3,4-tetrahydronaphth-1-yl]amino]-(2S)-2-propanol oxalate salt

SR 59230A

1-(2-ETHYLPHENOXY)-3-[[(1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL]AMINO]-(2S)-2-PROPANOL HYDROCHLORIDE

SR 59230A >=98% (HPLC), powder

(S)-1-(2-Ethylphenoxy)-3-(((S)-1,2,3,4-tetrahydronaphthalen-1-yl)amino)propan-2-ol oxalate

hyperthermia,adrenoceptor,Adrenergic Receptor,adrenergic,Beta Receptor,inhibit,hypothermia,receptor,Inhibitor,SR59230A,SR-59230A

(2S)-1-(2-ethylphenoxy)-3-{[(1S)-1,2,3,4-tetrahydronaphthalen-1-yl]amino}propan-2-ol

174689-39-5

C21H27NO2HCl

Adrenoceptor