ChemicalBook > CAS DataBase List > Schisandrin

Schisandrin

Product Name: Schisandrin
CAS No.: 7432-28-2
Chemical Name: Schisandrin
Synonyms: SCHISANDROL A;SCHIZANDRIN;SCHIZANDROL A;Schisandrol;SCHIZANDROL;12aR)-;schizandra;SCHISANDRIN;Schisadrol A;Schisandrinum
CBNumber: CB3334838
Molecular Formula: C24H32O7
Formula Weight: 432.51
MOL File: 7432-28-2.mol

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Schisandrin Property

Melting point:: 128.5°C
Boiling point:: 466.17°C (rough estimate)
Density: 1.1480 (rough estimate)
refractive index: 1.5800 (estimate)
storage temp.: 2-8°C
solubility: DMSO: ≥13mg/mL
pka: 14.58±0.40(Predicted)
form: powder
color: white to beige
optical activity: [α]/D 75 to 95°, c = 1 in methanol
InChI: InChI=1S/C24H32O7/c1-13-9-14-10-16(26-3)20(28-5)22(30-7)18(14)19-15(12-24(13,2)25)11-17(27-4)21(29-6)23(19)31-8/h10-11,13,25H,9,12H2,1-8H3
InChIKey: YEFOAORQXAOVJQ-UHFFFAOYSA-N
SMILES: O(C1C(=C(OC)C=C2CC(O)(C)C(C)CC3C=C(OC)C(OC)=C(OC)C=3C=12)OC)C
LogP: 3.153 (est)

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Safety

Hazard Codes: Xn,N
Risk Statements: 22-50/53
Safety Statements: 60-61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3
HS Code: 29093090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0054
Product name: Schizandrin
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $80.18
Updated: 2025/07/31

Sigma-Aldrich

Product number: Y0001818
Product name: Schizandrin
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 15 mg
Price: $153
Updated: 2025/07/31

Sigma-Aldrich

Product number: PHL89885
Product name: Schisandrol A
Purity: phyproof? Reference Substance
Packaging: 10MG
Price: $597
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1609895
Product name: Schisandrin
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 15mg
Price: $321
Updated: 2025/07/31

Cayman Chemical

Product number: 27211
Product name: Schizandrin
Packaging: 10mg
Price: $57
Updated: 2024/03/01

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Schisandrin Chemical Properties,Usage,Production

Description

Schizandrin is a dibenzocyclooctadiene lignan and a major component of S. chinensis and has diverse biological activities. It induces cell cycle arrest at the G₀/G₁ phase and inhibits growth of T47D and MDA-MB-231 breast cancer cells when used at a concentration of 100 μM. Schizandrin (10 and 100 μM) prevents glutamate-induced cytotoxicity, inhibits production of nitric oxide (NO) and reactive oxygen species (ROS), and preserves the mitochondrial membrane potential in isolated rat cortical cells. It reduces apoptosis induced by cisplatin in HK-2 human kidney cells. In vivo, schizandrin (1 and 10 mg/kg, p.o.) reverses scopolamine-induced impairment of spatial memory and the passive avoidance response in rats. It enhances oxotremorine-induced tremors in mice. Schizandrin (10 mg/kg) reduces serum levels of IgE, IgG1, IL-4, and IFN-γ in an ovalbumin-sensitized mouse model of allergy.

Chemical Properties

White crystals soluble in DMSO, slightly soluble in methanol and ethanol. Derived from the dried mature fruit of Schisandra chinensis (Turcz.) Baill., a plant of the Magnoliaceae family.

Uses

Schizandrin may be used in oxidative stress-related cell signaling studies.

Application

Schizandrin is a natural compound that belongs to the group of schisandrins. Schizandrins are a class of compounds with biochemical properties and biological activities, such as anti-inflammatory, antioxidant, and anti-cancer effects. This compound has been shown to have pro-apoptotic properties in a model system. It has also demonstrated the ability to inhibit influenza A virus replication in vitro and protect mice against Listeria monocytogenes infection. It can be used as an inhibitor of gsh-px activity in myocardial infarcts.

Definition

ChEBI: Schizandrin is a tannin.

Biochem/physiol Actions

Schizandrin is a natural product with several biological properties involved with antioxidant and anti-inflammatory activities. It reduces the formation of ROS, inhibits the mitochondrial pathway of the apoptotic process and oxidative stress. Schizandrin has been reported to have hepatoprotective, antitumor, antiviral, and antiamnesic effects, and has neuroprotective activity against glutamate induced neurotoxicity.

References

[1] SUN-JACK KIM. Growth inhibition and cell cycle arrest in the G0/G1 by schizandrin, a dibenzocyclooctadiene lignan isolated from Schisandra chinensis, on T47D human breast cancer cells.[J]. Phytotherapy Research, 2010, 24 2: 193-197. DOI: 10.1002/ptr.2907
[2] HAO-YUAN CHENG . Schizandrin Protects Primary Cultures of Rat Cortical Cells From Glutamate-Induced Excitotoxicity[J]. Journal of pharmacological sciences, 2008, 107 1: Pages 21-31. DOI: 10.1254/jphs.fp0072394
[3] VALéRIAN BUNEL. Protective effects of schizandrin and schizandrin B towards cisplatin nephrotoxicity in vitro.[J]. Journal of applied toxicology?: JAT, 2014: 1311-1319. DOI: 10.1002/jat.2951
[4] NOBUAKI EGASHIRA. Schizandrin reverses memory impairment in rats.[J]. Phytotherapy Research, 2008, 22 1: 49-52. DOI: 10.1002/ptr.2258
[5] NA‐RA HAN. Schisandra chinensis and Its Main Constituent Schizandrin Attenuate Allergic Reactions by Down-Regulating Caspase-1 in Ovalbumin-Sensitized Mice.[J]. The American journal of Chinese medicine, 2017, 45 1 1: 159-172. DOI: 10.1142/s0192415x17500112

Schisandrin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Schisandrin manufacturers

Lianyungang Kaiyu Environmental Tech Co., Ltd.

Product: Schizandrin 7432-28-2
Price: US $1200.00-1100.00/ton
Min. Order: 1ton
Purity: 99%
Supply Ability: 1000T/M
Release date: 2025-10-21

Wuhan JiyunZen Tech Co., Ltd.

Product: Schisandrin 7432-28-2
Price: US $5.00-0.50/KG
Min. Order: 1KG
Purity: 99% hplc
Supply Ability: 500TONS
Release date: 2025-05-08

Wuhan JiyunZen Tech Co., Ltd.

Product: Schisandrin 7432-28-2
Price: US $5.00-0.50/KG
Min. Order: 1KG
Purity: 99% hplc
Supply Ability: 500TONS
Release date: 2025-05-08

7432-28-2, SchisandrinRelated Search:

Dimethyl fumarate ETHANE Dimethyl sulfoxide Dimethyl phthalate S(-)-SCHISANDRIN,S(-) SCHISANDRIN B,SCHISANDRIN B,SCHISANDRIN, GAMMA-,GAMMA-SCHISANDRIN,SCHISANDRIN(SCHISANDROL A)(P) 4-Methoxybenzyl alcohol Schisandrin A N,N-Dimethylformamide Dimethyl carbonate Dimethyl sebacate Dimethyl ether Nortropine Gomisin A Benzo(3,4)cycloocta(1,2-f)(1,3)benzodioxol-1-ol, 5,6,7,8-tetrahydro-2, 3,13-trimethoxy-6,7-dimethyl-, stereoisomer 2-BUTENOIC ACID, 2-METHYL-, (5S,6S,7S,13AS)-5,6,7,13A-TETRAHYDRO-6-HYDROXY-1,2,3,13-TETRAMETHOXY-6,7-DIMETHYLBENZO[3,4]CYCLOOCTA[1,2-F][1,3]BENZODIOXOL-5-YL ESTER, (2Z)- schisanhenol WUWEIZISU C Schisantherin A

SCHIZANDROL

Schisandrin,Schizandrin

chisandrin 5,6,7,8-Tetrahydro-6,7-dimethyl-1,2 3,10,11,12-hexamethoxydibenzo[a,c]cycloocten-6-ol

Schizandrin, >=98%

Schizandrin, 98%, from Schisandra chinensis (Turcz.) Baill.

Schisandrae Berry Extract

Schisandrol A 7432-28-2

SCHIZANDROL A

SCHIZANDRIN

SCHISANDRIN

SCHISANDROL A

WUWEIZI ALCOHOL A

SCHISANDRIN (SCHISANDROL A)

Schizandrin std.

Schisandrin（Schizandrol A）

Schisadrol A

dibenzo(a,c)cycloocten-6-ol,5,6,7,8-tetrahydro-6,7-dimethyl-1,23,10,11,12-hex

schizandra

5,6,7,8-Tetrahydro-6,7-dimethyl-1,2 3,10,11,12-hexamethoxydibenzo[a,c]cycloocten-6-ol

(+)-Schizandrin Schisandrin Schisandrine Wuweizi alcohol A Schizandrin

1,2,3,10,11,12-hexamethoxy-6,7-dimethyl-,(6S,7S

12aR)-

Dibenzo[a,c]cycloocten-6-ol, 5,6,7,8-tetrahydro-

Schisandrol

5,6,7,8-Tetrahydro-1,2,3,10,11,12-hexamethoxy-6,7-dimethyldibenzo[a,c]cycloocten-6-ol

Schisandrin (Schizandrol

Dibenzo[a,c]cycloocten-6-ol, 5,6,7,8-tetrahydro-1,2,3,10,11,12-hexamethoxy-6,7-dimethyl-, (6S,7S,12aR)-

hot selling Schisandra Berries P.E

DeoxyschizandrinSchisandra chinensis extract

(6S,7S,12aR)-1,2,3,10,11,12-Hexamethoxy-6,7-dimethyl-5,6,7,8-tetrahydrodibenzo[a,c][8]annulen-6-ol

Schisandrin methyl

Schisandrol A structure

Abametapir Impurity 29

Schisandrin, 10 mM in DMSO

Schisandrinum

Extractum Schisandrae chinensis

Schisandra schisandrins

7432-28-2

C24H32O7

Inhibitors

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Miscellaneous Natural Products

Natural Plant Extract

chemical reagent

pharmaceutical intermediate