Cyclo (-RGDfK) 2,2,2-Trifluoroacetic acid

Product Name: Cyclo (-RGDfK) 2,2,2-Trifluoroacetic acid
CAS No.: 500577-51-5
Chemical Name: Cyclo (-RGDfK) 2,2,2-Trifluoroacetic acid
Synonyms: Cyclo(-RGDfK) Trifluoroacetate;Cyclo(-RGDfK) TFA, 10 mM in DMSO;Cyclo (-RGDfK) 2,2,2-Trifluoroacetic acid;Cyclo(-Arg-Gly-Asp-D-Phe-Lys) trifluoroacetate;2-((2S,5R,8S,11S)-8-(4-Aminobutyl)-5-benzyl-11-(3-guanidinopropyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecan-2-yl)acetic acid Trifluoroacetate (1:1)
CBNumber: CB33367651
Molecular Formula: C29H42F3N9O9
Formula Weight: 717.6938896
MOL File: 500577-51-5.mol

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Cyclo (-RGDfK) 2,2,2-Trifluoroacetic acid Property

storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: DMSO: 100 mg/mL (139.34 mM)
form: Solid
color: White to off-white
Water Solubility: Water: 33.33 mg/mL (46.44 mM)
Sequence: Cyclo(Arg-Gly-Asp-Phe-Lys)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0102584
Product name: Cyclo(-RGDfK)TFA
Purity: 99.81%
Packaging: 5mg
Price: $139
Updated: 2021/12/16

ChemScene

Product number: CS-0102584
Product name: Cyclo(-RGDfK)TFA
Purity: 99.81%
Packaging: 10mg
Price: $216
Updated: 2021/12/16

AK Scientific

Product number: 1378EC
Product name: Cyclo(-RGDfK)2,2,2-Trifluoroaceticacid
Packaging: 50mg
Price: $614
Updated: 2021/12/16

ChemScene

Product number: CS-0102584
Product name: Cyclo(-RGDfK)TFA
Purity: 99.81%
Packaging: 50mg
Price: $660
Updated: 2021/12/16

Crysdot

Product number: CD00003792
Product name: Cyclo(-RGDfK)2,2,2-Trifluoroaceticacid
Purity: 98+%
Packaging: 100mg
Price: $673
Updated: 2021/12/16

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Cyclo (-RGDfK) 2,2,2-Trifluoroacetic acid Chemical Properties,Usage,Production

Uses

Cyclo(-RGDfK) TFA is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM[1]. Cyclo(-RGDfK) TFA potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface[3].

IC 50

αvβ3: 0.94 nM (IC₅₀)

References

[1] Simecek J, et al. Benefits of NOPO as chelator in gallium-68 peptides, exemplified by preclinical characterization of (68)Ga-NOPO-c(RGDfK). Mol Pharm. 2014 May 5;11(5):1687-95. DOI:10.1021/mp5000746
[2] Lopez-Rodriguez V, et al. Preparation and preclinical evaluation of (66)Ga-DOTA-E(c(RGDfK))2 as a potential theranostic radiopharmaceutical. Nucl Med Biol. 2015 Feb;42(2):109-14. DOI:10.1016/j.nucmedbio.2014.09.010

Cyclo (-RGDfK) 2,2,2-Trifluoroacetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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Cyclo (-RGDfK) 2,2,2-Trifluoroacetic acid Suppliers

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500577-51-5, Cyclo (-RGDfK) 2,2,2-Trifluoroacetic acidRelated Search:

cyclo (Arg-Ala-Asp-d-Phe-Lys)

Cyclo (-RGDfK) 2,2,2-Trifluoroacetic acid

Cyclo(-RGDfK) Trifluoroacetate

2-((2S,5R,8S,11S)-8-(4-Aminobutyl)-5-benzyl-11-(3-guanidinopropyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecan-2-yl)acetic acid Trifluoroacetate (1:1)

Cyclo(-RGDfK) TFA, 10 mM in DMSO

Cyclo(-Arg-Gly-Asp-D-Phe-Lys) trifluoroacetate

500577-51-5