ChemicalBook > CAS DataBase List > Cyclo (-RGDfK) 2,2,2-Trifluoroacetic acid

Cyclo (-RGDfK) 2,2,2-Trifluoroacetic acid

Product Name
Cyclo (-RGDfK) 2,2,2-Trifluoroacetic acid
CAS No.
500577-51-5
Chemical Name
Cyclo (-RGDfK) 2,2,2-Trifluoroacetic acid
Synonyms
Cyclo(-RGDfK) Trifluoroacetate;Cyclo(-RGDfK) TFA, 10 mM in DMSO;Cyclo (-RGDfK) 2,2,2-Trifluoroacetic acid;Cyclo(-Arg-Gly-Asp-D-Phe-Lys) trifluoroacetate;2-((2S,5R,8S,11S)-8-(4-Aminobutyl)-5-benzyl-11-(3-guanidinopropyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecan-2-yl)acetic acid Trifluoroacetate (1:1)
CBNumber
CB33367651
Molecular Formula
C29H42F3N9O9
Formula Weight
717.6938896
MOL File
500577-51-5.mol
More
Less

Cyclo (-RGDfK) 2,2,2-Trifluoroacetic acid Property

storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
DMSO: 100 mg/mL (139.34 mM)
form 
Solid
color 
White to off-white
Water Solubility 
Water: 33.33 mg/mL (46.44 mM)
Sequence
Cyclo(Arg-Gly-Asp-Phe-Lys)
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

ChemScene
Product number
CS-0102584
Product name
Cyclo(-RGDfK)TFA
Purity
99.81%
Packaging
5mg
Price
$139
Updated
2021/12/16
ChemScene
Product number
CS-0102584
Product name
Cyclo(-RGDfK)TFA
Purity
99.81%
Packaging
10mg
Price
$216
Updated
2021/12/16
AK Scientific
Product number
1378EC
Product name
Cyclo(-RGDfK)2,2,2-Trifluoroaceticacid
Packaging
50mg
Price
$614
Updated
2021/12/16
ChemScene
Product number
CS-0102584
Product name
Cyclo(-RGDfK)TFA
Purity
99.81%
Packaging
50mg
Price
$660
Updated
2021/12/16
Crysdot
Product number
CD00003792
Product name
Cyclo(-RGDfK)2,2,2-Trifluoroaceticacid
Purity
98+%
Packaging
100mg
Price
$673
Updated
2021/12/16
More
Less

Cyclo (-RGDfK) 2,2,2-Trifluoroacetic acid Chemical Properties,Usage,Production

Uses

Cyclo(-RGDfK) TFA is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM[1]. Cyclo(-RGDfK) TFA potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface[3].

IC 50

αvβ3: 0.94 nM (IC50)

References

[1] Simecek J, et al. Benefits of NOPO as chelator in gallium-68 peptides, exemplified by preclinical characterization of (68)Ga-NOPO-c(RGDfK). Mol Pharm. 2014 May 5;11(5):1687-95. DOI:10.1021/mp5000746
[2] Lopez-Rodriguez V, et al. Preparation and preclinical evaluation of (66)Ga-DOTA-E(c(RGDfK))2 as a potential theranostic radiopharmaceutical. Nucl Med Biol. 2015 Feb;42(2):109-14. DOI:10.1016/j.nucmedbio.2014.09.010

Cyclo (-RGDfK) 2,2,2-Trifluoroacetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Cyclo (-RGDfK) 2,2,2-Trifluoroacetic acid Suppliers

China 33 India 1 United States 4 Global 38
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58

500577-51-5, Cyclo (-RGDfK) 2,2,2-Trifluoroacetic acidRelated Search:

cyclo (Arg-Ala-Asp-d-Phe-Lys)

  • Cyclo (-RGDfK) 2,2,2-Trifluoroacetic acid
  • Cyclo(-RGDfK) Trifluoroacetate
  • 2-((2S,5R,8S,11S)-8-(4-Aminobutyl)-5-benzyl-11-(3-guanidinopropyl)-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaazacyclopentadecan-2-yl)acetic acid Trifluoroacetate (1:1)
  • Cyclo(-RGDfK) TFA, 10 mM in DMSO
  • Cyclo(-Arg-Gly-Asp-D-Phe-Lys) trifluoroacetate
  • 500577-51-5