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ONC212

Product Name
ONC212
CAS No.
1807861-48-8
Chemical Name
ONC212
Synonyms
ONC212;DUN61488;ONC212 ，S8673;ONC 212;ONC-212;ONC212, 10 mM in DMSO;ONC 212;ONC-212;ONC212;1807861-48-8;ONC212,ONC-212,Inhibitor,ONC 212,inhibit,Apoptosis;7-Benzyl-4-(4-(trifluoromethyl)benzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one;Imidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, 2,4,6,7,8,9-hexahydro-7-(phenylmethyl)-4-[[4-(trifluoromethyl)phenyl]methyl]-
CBNumber
CB33367929
Molecular Formula
C24H23F3N4O
Formula Weight
440.46
MOL File
1807861-48-8.mol
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ONC212 Property

Boiling point:
549.9±60.0 °C(Predicted)
Density 
1.35±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF:1.0(Max Conc. mg/mL);2.27(Max Conc. mM)
DMSO:25.5(Max Conc. mg/mL);57.89(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.57(Max Conc. mM)
form 
A crystalline solid
pka
6.22±0.20(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
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N-Bromosuccinimide Price

TRC
Product number
O656510
Product name
ONC212
Packaging
2.5mg
Price
$550
Updated
2021/12/16
DC Chemicals
Product number
DC11417
Product name
ONC212
Purity
>98%
Packaging
250mg
Price
$950
Updated
2021/12/16
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ONC212 Chemical Properties,Usage,Production

Uses

ONC212, is an analogue of ONC201 (H291055), that is shown to a promising anti-cancer drug and also a selective agonist of GPR132.

in vivo

Biweekly oral administration of 50 mg/kg ONC212 markedly inhibits Acute myeloid leukemia (AML) expansion and prolongs overall survival (p=0.0003). Median survival increases from 43 d in controls to 49 d in the ONC212-treated group (+14%)[1].
ONC212 treatment exhibits significantly greater growth inhibition in comparison to ONC201. A dose of 50 mg/kg of ONC212 administered three-times a week is sufficient to lead to significant growth inhibition of tumors compare to the control group for these two models. Results demonstrate that ONC212 treated tumors show reduced proliferation in the HPAF-II model[2].
In vivo toxicity assessment experiments show that ONC212 is well tolerated up to 250 mg/kg. 300 mg/kg of ONC212 causes splenic damage and elevates liver enzymes. ONC212 has a slightly shorter half-life than ONC201, with a clearance from the blood at 12 hours, T1/2 of 4.3 hours, and Cmax of 1.4 μg/mL[3].

ONC212 Preparation Products And Raw materials

Raw materials

Preparation Products

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ONC212 Suppliers

China 59 United States 7 Global 66
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
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58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
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58
Abcam Limited
Tel
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Fax
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Email
us.orders@abcam.com
Country
United States
ProdList
6001
Advantage
50
Cayman Chemical Company
Tel
--
Fax
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Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
United States Biological
Tel
--
Fax
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Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
MedChemExpress
Tel
--
Fax
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Email
sales@medchemexpress.com
Country
United States
ProdList
6398
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View Lastest Price from ONC212 manufacturers

Zhejiang J&C Biological Technology Co.,Limited
Product
ONC212 1807861-48-8
Price
US $0.00/gram
Min. Order
1gram
Purity
99%
Supply Ability
10kg
Release date
2022-02-18

1807861-48-8, ONC212Related Search:


  • ONC212
  • ONC 212;ONC-212;ONC212;1807861-48-8
  • ONC 212;ONC-212
  • Imidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, 2,4,6,7,8,9-hexahydro-7-(phenylmethyl)-4-[[4-(trifluoromethyl)phenyl]methyl]-
  • 7-Benzyl-4-(4-(trifluoromethyl)benzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one
  • DUN61488
  • ONC212,ONC-212,Inhibitor,ONC 212,inhibit,Apoptosis
  • ONC212, 10 mM in DMSO
  • ONC212 ，S8673
  • 1807861-48-8
  • APIs