ChemicalBook > CAS DataBase List > 4beta-Hydroxywithanolide E

4beta-Hydroxywithanolide E

Product Name
4beta-Hydroxywithanolide E
CAS No.
54334-04-2
Chemical Name
4beta-Hydroxywithanolide E
Synonyms
4β-HydroxywithanolideE;4β-Hydroxywithanolide E;4beta-Hydroxywithanolide E;5β,6β-epoxy-4β,14,17α,20,22R-pentahydroxy-1-oxo-ergosta-2,24-dien-26-oic acid, ?-lactone;Ergosta-2,24-dien-26-oic acid, 5,6-epoxy-4,14,17,20,22-pentahydroxy-1-oxo-, δ-lactone, (4β,5β,6β,17α,22R)-
CBNumber
CB33372402
Molecular Formula
C28H38O8
Formula Weight
502.6
MOL File
54334-04-2.mol
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4beta-Hydroxywithanolide E Property

storage temp. 
Store at -20°C
solubility 
Chloroform: soluble; Ethanol: soluble; Methanol: soluble
form 
A crystalline solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
27245
Product name
4β-Hydroxywithanolide E
Packaging
1mg
Price
$763
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
INB0001928
Product name
4BETA-HYDROXYWITHANOLIDE E
Purity
95.00%
Packaging
5MG
Price
$505.84
Updated
2021/12/16
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4beta-Hydroxywithanolide E Chemical Properties,Usage,Production

Description

4β-Hydroxywithanolide E is a withanolide steroidal lactone that has been found in P. peruviana and has anti-inflammatory and anticancer activities.1,2,3 It inhibits LPS-induced nitric oxide (NO) production in RAW 264.7 cells and TNF-α-induced NF-κB activity in HEK293 cells (IC50s = 0.32 and 0.04 μM, respectively).1 4β-Hydroxywithanolide E (5 μM) inhibits LPS-induced increases in inducible nitric oxide synthase (iNOS) and COX-2 levels and Akt and STAT1 phosphorylation in RAW 264.7 cells.2 It inhibits Wnt signaling in HCT116 and SW480 colorectal cancer cells (IC50s = 1.85 and 2.67 μM, respectively).3 4β-Hydroxywithanolide E inhibits the proliferation of HCT116, SW480, HT-29, and LoVo cells (IC50s = 0.24-0.51 μM). It halts the cell cycle at the G0/G1 phase in HCT116 and HT-29 cells and induces apoptosis in HCT116 and SW480 cells in a concentration-dependent manner. 4β-Hydroxywithanolide E (10 mg/kg per day for 14 days) reduces tumor growth in an HCT116 mouse xenograft model.

Definition

ChEBI: 4beta-Hydroxywithanolide E is a withanolide.

References

1. Sang-Ngern, M., Youn, U.J., Park, E.J., et al. Withanolides derived from Physalis peruviana (Poha) with potential anti-inflammatory activity Bioorg. Med. Chem. Lett. 26(12),2755-2759(2016).
2. Park, E.J., Sang-Ngern, M., Chang, L.C., et al. Physalactone and 4β-hydroxywithanolide E isolated from Physalis peruviana inhibit LPS-induced expression of COX-2 and iNOS accompanied by abatement of Akt and STAT1 J. Nat. Prod. 82(3),492-499(2019).
3. Ye, Z.N., Yuan, F., Liu, J.Q., et al. Physalis peruviana-derived 4β-hydroxywithanolide E, a novel antagonist of Wnt signaling, inhibits colorectal cancer in vitro and in vivo Molecules 24(6),E1146(2019).

4beta-Hydroxywithanolide E Preparation Products And Raw materials

Raw materials

Preparation Products

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4beta-Hydroxywithanolide E Suppliers

China 25 United States 2 Global 27
BioBioPha Co., Ltd.
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54334-04-2, 4beta-Hydroxywithanolide ERelated Search:

WITHAFERIN A Withanolide C WITHANOLIDE A(P) 2,3-DIHYDROWITHAFERINA Withanolides WITHAFERIN A(P) Powdered Ashwagandha Root Extract (1 g) WITHANOLIDE D(P) WITHANOSIDEIV Withania somnifera, ext. ASHWAGANDHA EXTRACT 6α-chloro-5β-hydroxywithaferin A 3-Methoxy-2, 3-dihydrowithaferin-A WITHANOLIDE B(P)(NEW) (1alpha,3beta,22R)-3-[(6-O-beta-D-Glucopyranosyl-beta-D-glucopyranosyl)oxy]-1,22-dihydroxyergosta-5,24-dien-26-oic acid delta-lactone (22R)-5β,6β-Epoxy-3-methoxy-1-oxo-4β,22,27-trihydroxyergost-24-en-26-oic acid 26,22-lactone

  • 4beta-Hydroxywithanolide E
  • 4β-Hydroxywithanolide E
  • Ergosta-2,24-dien-26-oic acid, 5,6-epoxy-4,14,17,20,22-pentahydroxy-1-oxo-, δ-lactone, (4β,5β,6β,17α,22R)-
  • 4β-HydroxywithanolideE
  • 5β,6β-epoxy-4β,14,17α,20,22R-pentahydroxy-1-oxo-ergosta-2,24-dien-26-oic acid, ?-lactone
  • 54334-04-2