WITHANOLIDE B(P)(NEW)

Product Name: WITHANOLIDE B(P)(NEW)
CAS No.: 56973-41-2
Chemical Name: WITHANOLIDE B(P)(NEW)
Synonyms: Withanolide B;Withanolide B-RM;WITHANOLIDE B(SH);Withanolide B(AS);Lycium substance B;WITHANOLIDE B(P)(NEW);WITHANOLIDE B(SH)(NEW);Withanolide B 56973-41-2;(5a,6a,7a,22R)-6,7-Epoxy-5,22-dihydroxy-1-oxoergosta-2,24-dien-26-oic acid d-lactone;(5α,6α,7α,22R)-6,7-Epoxy-5,22-dihydroxy-1-oxo-ergosta-2,24-dien-26-oic acid δ-lactone
CBNumber: CB1500956
Molecular Formula: C28H38O5
Formula Weight: 454.6
MOL File: 56973-41-2.mol

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WITHANOLIDE B(P)(NEW) Property

Density: 1.206
storage temp.: Store at -20°C
solubility: Acetonitrile: 0.1 mg/ml; Methanol: 0.5 mg/ml
form: Solid
color: White to off-white
InChIKey: ZTEVDTFJUUJBLP-MBMSZCMESA-N

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 11798
Product name: Withanolide B
Packaging: 1mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 11798
Product name: Withanolide B
Packaging: 10mg
Price: $435
Updated: 2024/03/01

Cayman Chemical

Product number: 11798
Product name: Withanolide B
Packaging: 5mg
Price: $298
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: SHG0005937
Product name: Withanolide B
Purity: 95.00%
Packaging: 5MG
Price: $498.01
Updated: 2021/12/16

AvaChem

Product number: 4492
Product name: Withanolide B
Packaging: 1mg
Price: $59
Updated: 2021/12/16

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WITHANOLIDE B(P)(NEW) Chemical Properties,Usage,Production

Uses

Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects[1][2][3].

Definition

ChEBI: Withanolide B is a withanolide.

in vivo

Withanolide B (10 mg/kg; topical administration) promotes bone healing in a rat tibial defect model^[1].

Animal Model:	Male Sprague-Dawley rats (8 weeks, 200 g) with tibial defect^[1]
Dosage:	10 mg/kg
Administration:	Injected in situ at the bone defect site at different time points (0, 3, 5, 7, and 9 days)
Result:	Increased the trabecular number, trabecular thickness and the thickness of the cortical bone.

References

[1] Kuang Z, et, al. Withanolide B promotes osteogenic differentiation of human bone marrow mesenchymal stem cells via ERK1/2 and Wnt/β-catenin signaling pathways. Int Immunopharmacol. 2020 Nov;88:106960. DOI:10.1016/j.intimp.2020.106960
[2] Dubey S, et, al. Improving the inhibition of β-amyloid aggregation by withanolide and withanoside derivatives. Int J Biol Macromol. 2021 Mar 15;173:56-65. DOI:10.1016/j.ijbiomac.2021.01.094
[3] Sivanandha G, et, al. Enhanced biosynthesis of withanolides by elicitation and precursor feeding in cell suspension culture of Withania somnifera (L.) Dunal in shake-flask culture and bioreactor. PLoS One. 2014 Aug 4;9(8):e104005. DOI:10.1371/journal.pone.0104005

WITHANOLIDE B(P)(NEW) Preparation Products And Raw materials

Raw materials

Preparation Products

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WITHANOLIDE B(P)(NEW) Suppliers

China 55 India 4 United States 5 USA 1 Global 65

Chembest Research Laboratories Limited

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View Lastest Price from WITHANOLIDE B(P)(NEW) manufacturers

NanJing Spring & Autumn Biological Engineering CO., LTD.

Product: Withanolide B 56973-41-2 56973-41-2
Price: US $18.00/g
Min. Order: 1g
Purity: ≥98%
Supply Ability: 1000.00 kgs
Release date: 2019-07-17

56973-41-2, WITHANOLIDE B(P)(NEW)Related Search:

Vitamin B6 WITHANOLIDE A(P) (1alpha,3beta,22R)-3-[(6-O-beta-D-Glucopyranosyl-beta-D-glucopyranosyl)oxy]-1,22-dihydroxyergosta-5,24-dien-26-oic acid delta-lactone Withanolides Withanolide C buddlejasaponin IV (22R)-5β,6β-Epoxy-3-methoxy-1-oxo-4β,22,27-trihydroxyergost-24-en-26-oic acid 26,22-lactone (13R,22R)-13,14:18,20-Diepoxy-14,18,22-trihydroxy-1-oxo-13,14-secoergosta-2,5,24-trien-26-oic acid 26,22-lactone (22R)-14,20,22-Trihydroxy-1-oxoergosta-2,5,24-triene-18,26-dioic acid 18,20:26,22-dilactone Withaphysalin E Withaperuvin C WITHANOSIDEIV Withaphysalin S (22R)-5α,17α-Dihydroxy-6α,7α:22,26-diepoxyergosta-2,24-diene-1,26-dione WILFORINE WILFORDINE WILFORGINE wilfortrine

Withanolide B 56973-41-2

WITHANOLIDE B(SH)(NEW)

(5a,6a,7a,22R)-6,7-Epoxy-5,22-dihydroxy-1-oxoergosta-2,24-dien-26-oic acid d-lactone

Lycium substance B

Withanolide B

WITHANOLIDE B(SH)

(5α,6α,7α,22R)-6,7-Epoxy-5,22-dihydroxy-1-oxo-ergosta-2,24-dien-26-oic acid δ-lactone

WITHANOLIDE B(P)(NEW)

Ergosta-2,24-dien-26-oic acid, 6,7-epoxy-5,22-dihydroxy-1-oxo-, δ-lactone, (5α,6α,7α,22R)-

Withanolide B(AS)

Withanolide B-RM

56973-41-2