ChemicalBook > CAS DataBase List > SODIUM 2-(4-METHOXYPHENOXY)PROPIONATE

SODIUM 2-(4-METHOXYPHENOXY)PROPIONATE

Product Name: SODIUM 2-(4-METHOXYPHENOXY)PROPIONATE
CAS No.: 13794-15-5
Chemical Name: SODIUM 2-(4-METHOXYPHENOXY)PROPIONATE
Synonyms: Lactisol;FEMA 3773;Sweetness;Sweet pink;ODIUM 2-(4-;SODIUM 2-(4-;Sweetness inhibitor;Lactisole (free acid);Propanoic acid,2-(4-methoxyphe.;SODIUM2-(4-METHOXYPHENOXY)PROPANOATE
CBNumber: CB3338467
Molecular Formula: C10H12O4
Formula Weight: 196.2
MOL File: 13794-15-5.mol

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SODIUM 2-(4-METHOXYPHENOXY)PROPIONATE Property

Melting point:: 92-94℃
Boiling point:: 173-175 °C(Press: 1 Torr)
Density: 1.185
FEMA: 3773 | SODIUM 2-(4-METHOXYPHENOXY)PROPANOATE
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 3.29±0.10(Predicted)
color: Pale Brown to Brown
biological source: synthetic (organic)
JECFA Number: 1029
LogP: 1.650 (est)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 2918999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: M6546
Product name: (±)-2-(p-Methoxyphenoxy)propionic acid
Purity: ≥98%
Packaging: 100mg
Price: $182
Updated: 2025/07/31

Sigma-Aldrich

Product number: M6546
Product name: (±)-2-(p-Methoxyphenoxy)propionic acid
Purity: ≥98%
Packaging: 500mg
Price: $651
Updated: 2025/07/31

TRC

Product number: M329623
Product name: 2-(4-Methoxyphenoxy)propanoicacid
Packaging: 250mg
Price: $55
Updated: 2021/12/16

AK Scientific

Product number: J98937
Product name: 2-(4-Methoxyphenoxy)propanoicacid
Packaging: 25g
Price: $420
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0001124
Product name: 2-(4-METHOXYPHENOXY)PROPIONIC ACID
Purity: 95.00%
Packaging: 1G
Price: $692.46
Updated: 2021/12/16

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SODIUM 2-(4-METHOXYPHENOXY)PROPIONATE Chemical Properties,Usage,Production

Chemical Properties

2-(4-Methoxyphenoxy)propanoate is a potent inhibitor of the sweetness of sucrose and other sweeteners.

Chemical Properties

Lactisole, the sodium salt of racemic 2(4 methoxyphenoxy) propionic acid, is a sweet-taste inhibitor marketed by Domino Sugar. It was affirmed as a GRAS flavor (FEMA no. 3773). At a concentration of 100–150 ppm, lactisole eliminates the sweet taste of a 10% sugar solution. This inhibition appears to be receptor related because lactisole also inhibits the sweet taste of aspartame. The (S?) enantiomer [CAS: 4276-74-8] (38), isolated from roasted coffee beans, is the active isomer; the (R+) enantiomer is inert.

Occurrence

Reported found in coffee beans.

Uses

Sodium 2-(4-methoxyphenoxy)propanoic acid is a taste modulator that inhibits the perception of sweetness in humans, but not in rats.

Definition

ChEBI: (S)-2-(4-Methoxyphenoxy)propanoic acid is a carboxylic acid and an aromatic ether.

Biochem/physiol Actions

As a taste modulator, the sodium salt inhibits the perception of sweetness in humans, but not in rats.

Synthesis

17639-93-9

150-76-5

13794-15-5

(1) Add p-methoxyphenol (10 kg), sodium hydroxide (10 kg), potassium iodide (0.12 kg) and water (100 kg) to the reaction vessel and stir for 30 minutes at room temperature. Subsequently, the reaction mixture was heated to 60°C and the temperature was maintained in the range of 60°C to 70°C. At this temperature, methyl 2-chloropropionate (11.85 kg) was added slowly and dropwise. The reaction was catalyzed by potassium iodide and p-methoxyphenol reacted with methyl 2-chloropropionate while sodium hydroxide continued to react with the resulting acid. The reaction temperature was maintained in the range of 60°C to 90°C. The reaction was carried out for 12 hours and then completed; (2) the reaction product was cooled to room temperature, and a 30% sulfuric acid solution was slowly added, and the addition of acid was stopped after adjusting the pH of the mixture to 2.0. Subsequently, the mixture was cooled to below 45°C and centrifuged to obtain white solid 2-(4-methoxyphenoxy)propionic acid (14.28 kg).

References

[1] Patent: US4760172, 1988, A
[2] Patent: CN103922923, 2016, B. Location in patent: Paragraph 0029; 0030

SODIUM 2-(4-METHOXYPHENOXY)PROPIONATE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from SODIUM 2-(4-METHOXYPHENOXY)PROPIONATE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: SODIUM 2-(4-METHOXYPHENOXY)PROPIONATE 13794-15-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-25

Hebei Yanxi Chemical Co., Ltd.

Product: SODIUM 2-(4-METHOXYPHENOXY)PROPIONATE 13794-15-5
Price: US $30.00-25.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 30 tons
Release date: 2024-03-05

Jiangsu Monade Biological Technology Co., Ltd.

Product: 2-(4-Methoxyphenoxy)propanoic acid 13794-15-5
Price: US $0.00/ASSAYS
Min. Order: 100ASSAYS
Purity: 99.99%
Supply Ability: 10000
Release date: 2021-09-03

13794-15-5, SODIUM 2-(4-METHOXYPHENOXY)PROPIONATERelated Search:

Fenoxaprop-P 2-[4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxyphenoxy]propanoic acid Diclofop-methyl FENOXAPROP-ETHYL Haloxyfop-etotyl Fluazifop-butyl FENOXAPROP Quizalofop-p-ethyl FLUAZIFOP Diclofop Methyl 2-(4-((3-chloro-5-(trifluoromethyl)-2-pyridinyl)oxy)phenoxy)propanoate Quizalofop-P QUIZALOFOP SODIUM 2-(4-METHOXYPHENOXY)PROPIONATE DL-2-[4-(TRIFLUOROMETHOXY)PHENOXY]PROPIONIC ACID (R)-6-METHOXY-2,5,7,8-TETRAMETHYLCHROMANE-2-CARBOXYLIC ACID QUIZALOFOP METHYL DICLOFOP METHYL, 5-HYDROXY

FEMA 3773

SODIUM 2-(4-METHOXYPHENOXY)PROPIONATE

Propanoic acid, 2-(4-methoxyphenoxy)-

SODIUM2-(4-METHOXYPHENOXY)PROPANOATE

2-(4-METHOXYPHENOXY)PROPIONIC ACID SODIUM SALT

Lactisol

Sweetness inhibitor

Sweetness

Cover sweet powder (inhibiting sweetener)

Sweet pink

Propanoic acid,2-(4-methoxyphe.

(+/-)-2-(p-Methoxyphenoxy)propionic acid

(±)-2-(p-Methoxyphenoxy)propionicaci

SODIUM 2-(4-METHOXYPHENOXY)PROPIONATE USP/EP/BP

TIANFU CHEM--SODIUM 2-(4-METHOXYPHENOXY)PROPIONATE

Lactisole (free acid)

ODIUM 2-(4-

SODIUM 2-(4-

(±)-2-(p-Methoxyphenoxy)propionic acid

13794-15-5

C10H11NaO4