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KDU691

Product Name
KDU691
CAS No.
1513879-19-0
Chemical Name
KDU691
Synonyms
KDU691;KDU691 >=98% (HPLC);KDU691;KDU-691;KDU 691;1513879-19-0;Imidazo[1,2-a]pyrazine-6-carboxamide, N-(4-chlorophenyl)-N-methyl-3-[4-[(methylamino)carbonyl]phenyl]-;PI4 kinases,blood,Inhibitor,liver,Phosphatidylinositol 4 kinases,ring-stage,falciparum,Parasite,plasmodium,schizonts,gametocytes,KDU 691,PI4K,KDU-691,inhibit,KDU691,stage
CBNumber
CB33384777
Molecular Formula
C22H18ClN5O2
Formula Weight
419.86
MOL File
1513879-19-0.mol
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KDU691 Property

Density 
1.35±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:PBS (pH 7.2) (1:9):0.1(Max Conc. mg/mL);0.24(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);23.82(Max Conc. mM)
form 
A crystalline solid
pka
14.59±0.46(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29019
Product name
KDU691
Packaging
1mg
Price
$59
Updated
2024/03/01
Cayman Chemical
Product number
29019
Product name
KDU691
Packaging
25mg
Price
$699
Updated
2024/03/01
Cayman Chemical
Product number
29019
Product name
KDU691
Packaging
5mg
Price
$184
Updated
2024/03/01
Cayman Chemical
Product number
29019
Product name
KDU691
Packaging
10mg
Price
$336
Updated
2024/03/01
TRC
Product number
K145605
Product name
KDU691
Packaging
2.5mg
Price
$535
Updated
2021/12/16
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KDU691 Chemical Properties,Usage,Production

Description

KDU691 is an antimalarial compound. It inhibits recombinant P. vivax phosphatidylinositol 4-kinase (PI4K) with an IC50 value of 1.5 nM. KDU691 is selective for P. vivax PI4K over recombinant human PI4KβIII and PI3Kα, -β, -γ, and -δ (IC50s = 7.9, 8.8, 2.4, 8, and 3.4 μM, respectively), as well as VPS34 (IC50 = >9.7 μM) and 36 additional kinases in a panel of lipid and protein kinases (IC50s = >10 μM). It is active against P. falciparum and P. yoelii schizonts (IC50s = 0.06 and 0.04 μM, respectively), as well as P. cynomolgi schizonts and hypnozoites (IC50s = 0.11 and 0.2 μM, respectively). KDU691 completely prevents, but does not eradicate established, P. cynomolgi infection in rhesus monkeys when administered at a dose of 20 mg/kg.

Uses

KDU691, is a PI4K inhibitor.

KDU691 Preparation Products And Raw materials

Raw materials

Preparation Products

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KDU691 Suppliers

Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696,15000506266 15000506266
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+86-21-52996696
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China
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
Fax
021-65675885
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info@efebio.com
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China
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9708
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58
ShangHai Biochempartner Co.,Ltd
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17754423994 17754423994
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QQ:2853530913
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2853530910@QQ.com
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China
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Shanghai Chaolan Chemical Technology Center
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QQ:65489617 15618227136
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21-5161 9052
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info@SuperLan-chem.com
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China
ProdList
9833
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Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
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China
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Twochem Co.Ltd.
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021-58111628 15800915896
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QQ 3285589261
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China
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Angel Pharmatech, Ltd.
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17317130613
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QQ3358272972
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3358272972@qq.com
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Tianjin Kaifu Pharmaceutical Technology Co., Ltd.
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18081075745
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chemflowtech@sina.com
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HANGZHOU CLAP TECHNOLOGY CO.,LTD
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86-571-88216897,88216896 13588875226
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86-571-88216895
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sales@hzclap.com
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DC Chemicals
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021-58447131 13564518121
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sales@dcchemicals.com
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China
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Changzhou Chenhong Biotechnology Co., Ltd.
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0519-85788828 13775037613
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sales@chemrenpharm.com
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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18818260767
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QQ 3610331285
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Absin Bioscience Inc.
Tel
021-38015121 15000105423
Email
chenjw@absin.cn
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China
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Shanghai hongqu biomedical technology co. LTD
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88888888888
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hongquchem@qq.com
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Chunchuang (Wuhan) Technology Co., Ltd
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yutianchun2007@126.com
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Energy Chemical
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021-58432009 400-005-6266
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marketing1@energy-chemical.com
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Jinan Jiuli Biotechnology Co. , Ltd.
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2717893647 14768611851
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486064515@qq.com
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Shanghai tingchong biology science and technology co., ltd
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China
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Beijing Jin Ming Biotechnology Co., Ltd.
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010-60605840
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psaitong@jm-bio.com
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China
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Bide Pharmatech Ltd.
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product02@bidepharm.com
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InvivoChem
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sales@invivochem.cn
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China
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TargetMol Chemicals Inc.
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4008200310
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marketing@tsbiochem.com
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Shanghai Jieshikai Biotechnology Co. , Ltd.
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13764600721
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wangkang@jskchem.com
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Nanjing Shizhou Biology Technology Co.,Ltd
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Shanghai Aladdin Biochemical Technology Co.,Ltd.
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YJ Pharma
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ATK CHEMICAL COMPANY LIMITED
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Shanghai Hao Zhun Biological Technology Co., Ltd.
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1513879-19-0, KDU691Related Search:


  • KDU691
  • KDU691;KDU-691;KDU 691;1513879-19-0
  • KDU691 >=98% (HPLC)
  • Imidazo[1,2-a]pyrazine-6-carboxamide, N-(4-chlorophenyl)-N-methyl-3-[4-[(methylamino)carbonyl]phenyl]-
  • PI4 kinases,blood,Inhibitor,liver,Phosphatidylinositol 4 kinases,ring-stage,falciparum,Parasite,plasmodium,schizonts,gametocytes,KDU 691,PI4K,KDU-691,inhibit,KDU691,stage
  • 1513879-19-0