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KDU691

Product Name
KDU691
CAS No.
1513879-19-0
Chemical Name
KDU691
Synonyms
KDU691;KDU691 >=98% (HPLC);KDU691;KDU-691;KDU 691;1513879-19-0;Imidazo[1,2-a]pyrazine-6-carboxamide, N-(4-chlorophenyl)-N-methyl-3-[4-[(methylamino)carbonyl]phenyl]-;PI4 kinases,blood,Inhibitor,liver,Phosphatidylinositol 4 kinases,ring-stage,falciparum,Parasite,plasmodium,schizonts,gametocytes,KDU 691,PI4K,KDU-691,inhibit,KDU691,stage
CBNumber
CB33384777
Molecular Formula
C22H18ClN5O2
Formula Weight
419.86
MOL File
1513879-19-0.mol
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KDU691 Property

Density 
1.35±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:PBS (pH 7.2) (1:9):0.1(Max Conc. mg/mL);0.24(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);23.82(Max Conc. mM)
form 
A crystalline solid
pka
14.59±0.46(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29019
Product name
KDU691
Packaging
1mg
Price
$59
Updated
2024/03/01
Cayman Chemical
Product number
29019
Product name
KDU691
Packaging
25mg
Price
$699
Updated
2024/03/01
Cayman Chemical
Product number
29019
Product name
KDU691
Packaging
5mg
Price
$184
Updated
2024/03/01
Cayman Chemical
Product number
29019
Product name
KDU691
Packaging
10mg
Price
$336
Updated
2024/03/01
TRC
Product number
K145605
Product name
KDU691
Packaging
2.5mg
Price
$535
Updated
2021/12/16
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KDU691 Chemical Properties,Usage,Production

Description

KDU691 is an antimalarial compound. It inhibits recombinant P. vivax phosphatidylinositol 4-kinase (PI4K) with an IC50 value of 1.5 nM. KDU691 is selective for P. vivax PI4K over recombinant human PI4KβIII and PI3Kα, -β, -γ, and -δ (IC50s = 7.9, 8.8, 2.4, 8, and 3.4 μM, respectively), as well as VPS34 (IC50 = >9.7 μM) and 36 additional kinases in a panel of lipid and protein kinases (IC50s = >10 μM). It is active against P. falciparum and P. yoelii schizonts (IC50s = 0.06 and 0.04 μM, respectively), as well as P. cynomolgi schizonts and hypnozoites (IC50s = 0.11 and 0.2 μM, respectively). KDU691 completely prevents, but does not eradicate established, P. cynomolgi infection in rhesus monkeys when administered at a dose of 20 mg/kg.

Uses

KDU691, is a PI4K inhibitor.

KDU691 Preparation Products And Raw materials

Raw materials

Preparation Products

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KDU691 Suppliers

China 28 United States 7 USA 1 Global 36
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
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China
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4182
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Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
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China
ProdList
9708
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58
ShangHai Biochempartner Co.,Ltd
Tel
17754423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
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China
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8011
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Shanghai Chaolan Chemical Technology Center
Tel
QQ:65489617 15618227136
Fax
21-5161 9052
Email
info@SuperLan-chem.com
Country
China
ProdList
9838
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58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12308
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58
Twochem Co.Ltd.
Tel
021-58111628 15800915896
Fax
QQ 3285589261
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China
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1988
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58
Angel Pharmatech, Ltd.
Tel
17317130613
Fax
QQ3358272972
Email
3358272972@qq.com
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China
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3246
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58
Tianjin Kaifu Pharmaceutical Technology Co., Ltd.
Tel
18081075745
Email
chemflowtech@sina.com
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China
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1886
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HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel
86-571-88216897,88216896 13588875226
Fax
86-571-88216895
Email
sales@hzclap.com
Country
CHINA
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6313
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DC Chemicals
Tel
021-58447131 13564518121
Email
sales@dcchemicals.com
Country
China
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9412
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Changzhou Chenhong Biotechnology Co., Ltd.
Tel
0519-85788828 13775037613
Email
sales@chemrenpharm.com
Country
China
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3574
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
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11289
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58
Absin Bioscience Inc.
Tel
021-38015121 15000105423
Email
chenjw@absin.cn
Country
China
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24734
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58
Shanghai hongqu biomedical technology co. LTD
Tel
88888888888
Email
hongquchem@qq.com
Country
China
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5132
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Chunchuang (Wuhan) Technology Co., Ltd
Tel
15342225168
Email
yutianchun2007@126.com
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China
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Energy Chemical
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021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
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China
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44843
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Jinan Jiuli Biotechnology Co. , Ltd.
Tel
2717893647 14768611851
Email
486064515@qq.com
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China
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1554
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Shanghai tingchong biology science and technology co., ltd
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18964309092 18964309092
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2769493375@qq.com
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China
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Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840
Email
psaitong@jm-bio.com
Country
China
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29778
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58
Bide Pharmatech Ltd.
Tel
400-1647117 15221909166
Email
product02@bidepharm.com
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China
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63720
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InvivoChem
Tel
13549236410
Email
sales@invivochem.cn
Country
China
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6749
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TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
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China
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24017
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Shanghai Jieshikai Biotechnology Co. , Ltd.
Tel
021-57520305 15221441005
Email
wangkang@jskchem.com
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China
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49242
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Nanjing Shizhou Biology Technology Co.,Ltd
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025-85560043 15850508050
Fax
025-85563444
Email
cindy.huang@synzest.com
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China
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Shanghai Aladdin Biochemical Technology Co.,Ltd.
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+86-18521732826
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market@aladdin-e.com
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China
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48467
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YJ Pharma
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0513-15251351988 15251351988
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3686954964@qq.com
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China
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ATK CHEMICAL COMPANY LIMITED
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+undefined-21-51877795
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+86 21 5161 9052/ 5187 7796
Email
ivan@atkchemical.com
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China
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32715
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Shanghai Hao Zhun Biological Technology Co., Ltd.
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--
Fax
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Email
info@zzsrm.com
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CHINA
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6846
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58

1513879-19-0, KDU691Related Search:


  • KDU691
  • KDU691;KDU-691;KDU 691;1513879-19-0
  • KDU691 >=98% (HPLC)
  • Imidazo[1,2-a]pyrazine-6-carboxamide, N-(4-chlorophenyl)-N-methyl-3-[4-[(methylamino)carbonyl]phenyl]-
  • PI4 kinases,blood,Inhibitor,liver,Phosphatidylinositol 4 kinases,ring-stage,falciparum,Parasite,plasmodium,schizonts,gametocytes,KDU 691,PI4K,KDU-691,inhibit,KDU691,stage
  • 1513879-19-0