ChemicalBook > CAS DataBase List > KDU691

KDU691

Product Name: KDU691
CAS No.: 1513879-19-0
Chemical Name: KDU691
Synonyms: KDU691;KDU691 >=98% (HPLC);KDU691, 10 mM in DMSO;KDU691;KDU-691;KDU 691;1513879-19-0;N-(4-Chlorophenyl)-N-methyl-3-(4-(methylcarbamoyl)phenyl)imidazo[1,2-a]pyrazine-6-carboxamide;Imidazo[1,2-a]pyrazine-6-carboxamide, N-(4-chlorophenyl)-N-methyl-3-[4-[(methylamino)carbonyl]phenyl]-;PI4 kinases,blood,Inhibitor,liver,Phosphatidylinositol 4 kinases,ring-stage,falciparum,Parasite,plasmodium,schizonts,gametocytes,KDU 691,PI4K,KDU-691,inhibit,KDU691,stage
CBNumber: CB33384777
Molecular Formula: C22H18ClN5O2
Formula Weight: 419.86
MOL File: 1513879-19-0.mol

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KDU691 Property

Density: 1.35±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:PBS (pH 7.2) (1:9):0.1(Max Conc. mg/mL);0.24(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);23.82(Max Conc. mM)
form: A crystalline solid
pka: 14.59±0.46(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2375
Product name: KDU691
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $127.98
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2375
Product name: KDU691
Purity: ≥98% (HPLC)
Packaging: 25 mg
Price: $254.5
Updated: 2025/07/31

Cayman Chemical

Product number: 29019
Product name: KDU691
Packaging: 1mg
Price: $59
Updated: 2024/03/01

Cayman Chemical

Product number: 29019
Product name: KDU691
Packaging: 25mg
Price: $699
Updated: 2024/03/01

Cayman Chemical

Product number: 29019
Product name: KDU691
Packaging: 5mg
Price: $184
Updated: 2024/03/01

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KDU691 Chemical Properties,Usage,Production

Description

KDU691 is an antimalarial compound. It inhibits recombinant P. vivax phosphatidylinositol 4-kinase (PI4K) with an IC₅₀ value of 1.5 nM. KDU691 is selective for P. vivax PI4K over recombinant human PI4KβIII and PI3Kα, -β, -γ, and -δ (IC₅₀s = 7.9, 8.8, 2.4, 8, and 3.4 μM, respectively), as well as VPS34 (IC₅₀ = >9.7 μM) and 36 additional kinases in a panel of lipid and protein kinases (IC₅₀s = >10 μM). It is active against P. falciparum and P. yoelii schizonts (IC₅₀s = 0.06 and 0.04 μM, respectively), as well as P. cynomolgi schizonts and hypnozoites (IC₅₀s = 0.11 and 0.2 μM, respectively). KDU691 completely prevents, but does not eradicate established, P. cynomolgi infection in rhesus monkeys when administered at a dose of 20 mg/kg.

Uses

KDU691, is a PI4K inhibitor.

in vivo

During the 5 days of dosing, no major weight changes are observed in the animals that receive KDU691 as prophylactic treatment (group 691-proph). From the fourth day of dosing, the animals that are treated with KDU691 show a transient yellow skin color. The KDU691 radical-cure group (group 691-RC) becomes blood-stage positive again at 31.8 days p.i. (range, 31 to 32 days). Clinical chemistry analysis of the group 691-RC monkeys reveals that bilirubin levels accumulate during the 5-day radical-cure treatment with KDU691^[2].

IC 50

Plasmodium

References

[1] CASE W. MCNAMARA. Targeting Plasmodium PI(4)K to eliminate malaria[J]. Nature, 2013, 504 7479: 248-253. DOI: 10.1038/nature12782
[2] BIN ZOU*. Lead Optimization of Imidazopyrazines: A New Class of Antimalarial with Activity on Plasmodium Liver Stages[J]. ACS Medicinal Chemistry Letters, 2014, 5 8: 947-950. DOI: 10.1021/ml500244m
[3] A. ZEEMAN. PI4 Kinase Is a Prophylactic but Not Radical Curative Target in Plasmodium vivax-Type Malaria Parasites[J]. Antimicrobial Agents and Chemotherapy, 2016, 60 1: 2858-2863. DOI: 10.1128/aac.03080-15

KDU691 Preparation Products And Raw materials

Raw materials

Preparation Products

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KDU691 Suppliers

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1513879-19-0, KDU691Related Search:

KDU691

KDU691;KDU-691;KDU 691;1513879-19-0

KDU691 >=98% (HPLC)

Imidazo[1,2-a]pyrazine-6-carboxamide, N-(4-chlorophenyl)-N-methyl-3-[4-[(methylamino)carbonyl]phenyl]-

PI4 kinases,blood,Inhibitor,liver,Phosphatidylinositol 4 kinases,ring-stage,falciparum,Parasite,plasmodium,schizonts,gametocytes,KDU 691,PI4K,KDU-691,inhibit,KDU691,stage

KDU691, 10 mM in DMSO

N-(4-Chlorophenyl)-N-methyl-3-(4-(methylcarbamoyl)phenyl)imidazo[1,2-a]pyrazine-6-carboxamide

1513879-19-0