KDU691
- Product Name
- KDU691
- CAS No.
- 1513879-19-0
- Chemical Name
- KDU691
- Synonyms
- KDU691;KDU691 >=98% (HPLC);KDU691;KDU-691;KDU 691;1513879-19-0;Imidazo[1,2-a]pyrazine-6-carboxamide, N-(4-chlorophenyl)-N-methyl-3-[4-[(methylamino)carbonyl]phenyl]-;PI4 kinases,blood,Inhibitor,liver,Phosphatidylinositol 4 kinases,ring-stage,falciparum,Parasite,plasmodium,schizonts,gametocytes,KDU 691,PI4K,KDU-691,inhibit,KDU691,stage
- CBNumber
- CB33384777
- Molecular Formula
- C22H18ClN5O2
- Formula Weight
- 419.86
- MOL File
- 1513879-19-0.mol
KDU691 Property
- Density
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:PBS (pH 7.2) (1:9):0.1(Max Conc. mg/mL);0.24(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);23.82(Max Conc. mM) - form
- A crystalline solid
- pka
- 14.59±0.46(Predicted)
N-Bromosuccinimide Price
- Product number
- 29019
- Product name
- KDU691
- Packaging
- 1mg
- Price
- $59
- Updated
- 2024/03/01
- Product number
- 29019
- Product name
- KDU691
- Packaging
- 25mg
- Price
- $699
- Updated
- 2024/03/01
- Product number
- 29019
- Product name
- KDU691
- Packaging
- 5mg
- Price
- $184
- Updated
- 2024/03/01
- Product number
- 29019
- Product name
- KDU691
- Packaging
- 10mg
- Price
- $336
- Updated
- 2024/03/01
- Product number
- K145605
- Product name
- KDU691
- Packaging
- 2.5mg
- Price
- $535
- Updated
- 2021/12/16
KDU691 Chemical Properties,Usage,Production
Description
KDU691 is an antimalarial compound. It inhibits recombinant P. vivax phosphatidylinositol 4-kinase (PI4K) with an IC50 value of 1.5 nM. KDU691 is selective for P. vivax PI4K over recombinant human PI4KβIII and PI3Kα, -β, -γ, and -δ (IC50s = 7.9, 8.8, 2.4, 8, and 3.4 μM, respectively), as well as VPS34 (IC50 = >9.7 μM) and 36 additional kinases in a panel of lipid and protein kinases (IC50s = >10 μM). It is active against P. falciparum and P. yoelii schizonts (IC50s = 0.06 and 0.04 μM, respectively), as well as P. cynomolgi schizonts and hypnozoites (IC50s = 0.11 and 0.2 μM, respectively). KDU691 completely prevents, but does not eradicate established, P. cynomolgi infection in rhesus monkeys when administered at a dose of 20 mg/kg.
Uses
KDU691, is a PI4K inhibitor.