ZORUBICIN HCL

Product Name: ZORUBICIN HCL
CAS No.: 36508-71-1
Chemical Name: ZORUBICIN HCL
Synonyms: rubidaz;22050r.p.;nsc-164011;ZORUBICIN HCL;rp22,050hydrochloride;ZORUBICIN HCL USP/EP/BP;rubidazone,monohydrochloride;daunorubicin,benzoylhydrazone,monohydrochloride;benzoicacidhydrazide,3-hydrazonewithdaunorubicin,monohydrochloride;(2S-cis)-Benzoic acid[1-[4-[(3-amino-2，3，6-trideoxy-α-L-lyxo-hex-opyranosyl)oxy]-1，2，3，4，6，11-hexahydro-2，5，12-trihydroxy-7-methoxy-6，11-dioxo-2-napthacenyl]ethylidene]hydrazide hydroehloride
CBNumber: CB3339363
Molecular Formula: C34H36ClN3O10
Formula Weight: 682.12
MOL File: 36508-71-1.mol

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ZORUBICIN HCL Property

alpha: D20 -50° (c = 0.2 in water)
solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form: Solid
color: Orange to Dark Red
Stability:: Light Sensitive

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Safety

Toxicity: LD50 in mice (mg/kg): 13.66 s.c., 4.42 i.p., 8.50 i.v. (Maral, 1972)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: Z700550
Product name: ZorubicinHydrochloride
Packaging: 20mg
Price: $195
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0003637
Product name: ZORUBICIN HYDROCHLORIDE
Purity: 95.00%
Packaging: 5MG
Price: $503.99
Updated: 2021/12/16

AHH

Product number: MT-60610
Product name: ZorubicinHCl
Purity: 98%
Packaging: 0.1g
Price: $610
Updated: 2021/12/16

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ZORUBICIN HCL Chemical Properties,Usage,Production

Originator

Zorubicin Hydrochloride,ZYF Pharm Chemical

Uses

Zorubicin Hydrochloride is an anthracycline anti-cancer drug related to Daunorubicin (D194500).

Uses

Antineoplastic.

Manufacturing Process

9.024 g daunorubicin-hydrochloride (its preparation and physicochemical properties have been described in British Patent Specification No 985 598) was dissolved in 800 ml ethanol and mixed with 2.5 ml acetic acid and 2.162 g benzoyl hydrazide and heated for 24 hours at 60°C. On cooling the obtained precipitate was filtered off, washed with 100 ml of ethanol and dried in vacuum at 20°C. It was dissolved in water and small quantity of insoluble product was filtered off, the filtrate was lyophilized. (1-(4-((3-Amino-2,3,6- trideoxy-α,L-lyxohexopyranosyl)oxy)-1,2,3,4,6,11-hexahydro-2,5,12- trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl)ethylidene)hydrazide dihydrochloride (zorubicin) was obtained as red-orange crystalline powder; [α] D 20 = -50° (c=0.2 in water). The compound may be employed in the form of different non-toxic salts such as benzoates, fumarates, maleates, tartrates and so on. The best among these compounds proves to be daunorubicin benzoylhydrazone (rubidazone), which is less cardiotoxic (French Pat. No. 1,578,722 published in 1967, Class CO7d).

Therapeutic Function

Antineoplastic, Antileukemic

ZORUBICIN HCL Preparation Products And Raw materials

Raw materials

Benzoyl hydrazine Daunorubicin hydrochloride

Preparation Products

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ZORUBICIN HCL Suppliers

China 12 Europe 2 India 2 United Kingdom 4 United States 6 Global 26

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18042
Advantage: 56

Jinan Renyuan Chemical Co., Ltd.

Tel: 0531-86128689 18396852370
Fax: 0531-86128689
Email: 1840274076@qq.com
Country: China
ProdList: 279
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-029-89586680 +86-18192503167
Fax: +86-29-88380327
Email: 1026@dideu.com
Country: China
ProdList: 7724
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Nantong Hanfang Biotechnology Co. , Ltd.

Tel: 18616537568
Email: hanfangpharma@126.com
Country: China
ProdList: 30961
Advantage: 58

SHANGHAI KEAN TECHNOLOGY CO., LTD.

Tel: +8613817748580
Fax: 021-50175322
Email: cooperation@kean-chem.com
Country: China
ProdList: 40066
Advantage: 58

Henan Fengda Chemical Co., Ltd

Tel: +86-371-86557731 +86-13613820652
Fax: 86-0371-86557731
Email: info@fdachem.com
Country: China
ProdList: 20287
Advantage: 58

36508-71-1, ZORUBICIN HCLRelated Search:

Dideiodo AMiodarone Hydrochloride Ethambutol dihydrochloride 5-Des[2-(tert-butylaMino)] BaMbuterol-5-ethylenediol Bispyridoxine Thioridazine-d3 Hydrochloride 3-Hydroxy DetoMidine Hydrochloride 3-Dechloro-3-broMo Trazodone Hydrochloride 2-[3-[4-(3-chloro-4-ethylphenyl)piperazin-1-yl]propyl]-[1,2,4]triazolo[4,3-a]pyridin-3-one 1,2-Ethanediamine, N,N,N',N'-tetrakis(2-aminoethyl)- Halofuginone Hydrochloride Zorubicin D-LYXOSE Daunorubicin ZORUBICIN HCL L-DaunosamineHCl DAUNOSAMINE HYDROCHLORIDE 13-Deoxocarminomycin Feudomycin A

ZORUBICIN HCL

22050r.p.

benzoicacidhydrazide,3-hydrazonewithdaunorubicin,monohydrochloride

daunorubicin,benzoylhydrazone,monohydrochloride

nsc-164011

rp22,050hydrochloride

rubidaz

rubidazone,monohydrochloride

Benzoic acid, 1-(2S,4S)-4-(3-amino-2,3,6-trideoxy-.alpha.-L-lyxo-hexopyranosyl)oxy-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenylethylidenehydrazide, monohydrochloride

(2S-cis)-Benzoic acid[1-[4-[(3-amino-2，3，6-trideoxy-α-L-lyxo-hex-opyranosyl)oxy]-1，2，3，4，6，11-hexahydro-2，5，12-trihydroxy-7-methoxy-6，11-dioxo-2-napthacenyl]ethylidene]hydrazide hydroehloride

Benzoic acid, [1-[4-[(3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]ethylidene]hydrazide, monohydrochloride, (2S-cis)-

ZORUBICIN HCL USP/EP/BP

36508-71-1

C34H35N3O10HCl