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ZORUBICIN HCL

Product Name
ZORUBICIN HCL
CAS No.
36508-71-1
Chemical Name
ZORUBICIN HCL
Synonyms
rubidaz;22050r.p.;nsc-164011;ZORUBICIN HCL;rp22,050hydrochloride;ZORUBICIN HCL USP/EP/BP;rubidazone,monohydrochloride;daunorubicin,benzoylhydrazone,monohydrochloride;benzoicacidhydrazide,3-hydrazonewithdaunorubicin,monohydrochloride;(2S-cis)-Benzoic acid[1-[4-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hex-opyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-napthacenyl]ethylidene]hydrazide hydroehloride
CBNumber
CB3339363
Molecular Formula
C34H36ClN3O10
Formula Weight
682.12
MOL File
36508-71-1.mol
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ZORUBICIN HCL Property

alpha 
D20 -50° (c = 0.2 in water)
solubility 
DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form 
Solid
color 
Orange to Dark Red
Stability:
Light Sensitive
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Safety

Toxicity
LD50 in mice (mg/kg): 13.66 s.c., 4.42 i.p., 8.50 i.v. (Maral, 1972)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
Z700550
Product name
ZorubicinHydrochloride
Packaging
20mg
Price
$195
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
INB0003637
Product name
ZORUBICIN HYDROCHLORIDE
Purity
95.00%
Packaging
5MG
Price
$503.99
Updated
2021/12/16
AHH
Product number
MT-60610
Product name
ZorubicinHCl
Purity
98%
Packaging
0.1g
Price
$610
Updated
2021/12/16
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ZORUBICIN HCL Chemical Properties,Usage,Production

Originator

Zorubicin Hydrochloride,ZYF Pharm Chemical

Uses

Zorubicin Hydrochloride is an anthracycline anti-cancer drug related to Daunorubicin (D194500).

Uses

Antineoplastic.

Manufacturing Process

9.024 g daunorubicin-hydrochloride (its preparation and physicochemical properties have been described in British Patent Specification No 985 598) was dissolved in 800 ml ethanol and mixed with 2.5 ml acetic acid and 2.162 g benzoyl hydrazide and heated for 24 hours at 60°C. On cooling the obtained precipitate was filtered off, washed with 100 ml of ethanol and dried in vacuum at 20°C. It was dissolved in water and small quantity of insoluble product was filtered off, the filtrate was lyophilized. (1-(4-((3-Amino-2,3,6- trideoxy-α,L-lyxohexopyranosyl)oxy)-1,2,3,4,6,11-hexahydro-2,5,12- trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl)ethylidene)hydrazide dihydrochloride (zorubicin) was obtained as red-orange crystalline powder; [α] D 20 = -50° (c=0.2 in water). The compound may be employed in the form of different non-toxic salts such as benzoates, fumarates, maleates, tartrates and so on. The best among these compounds proves to be daunorubicin benzoylhydrazone (rubidazone), which is less cardiotoxic (French Pat. No. 1,578,722 published in 1967, Class CO7d).

Therapeutic Function

Antineoplastic, Antileukemic

ZORUBICIN HCL Preparation Products And Raw materials

Raw materials

Preparation Products

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ZORUBICIN HCL Suppliers

ecochem international chemical broker
Tel
--
Fax
--
Email
export@ecochem.dk
Country
Europe
ProdList
6371
Advantage
66
kemikalieimport
Tel
--
Fax
--
Email
Sales@kemikalieimport.dk
Country
Europe
ProdList
6685
Advantage
47

36508-71-1, ZORUBICIN HCLRelated Search:


  • ZORUBICIN HCL
  • 22050r.p.
  • benzoicacidhydrazide,3-hydrazonewithdaunorubicin,monohydrochloride
  • daunorubicin,benzoylhydrazone,monohydrochloride
  • nsc-164011
  • rp22,050hydrochloride
  • rubidaz
  • rubidazone,monohydrochloride
  • Benzoic acid, 1-(2S,4S)-4-(3-amino-2,3,6-trideoxy-.alpha.-L-lyxo-hexopyranosyl)oxy-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenylethylidenehydrazide, monohydrochloride
  • (2S-cis)-Benzoic acid[1-[4-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hex-opyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-napthacenyl]ethylidene]hydrazide hydroehloride
  • Benzoic acid, [1-[4-[(3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl]ethylidene]hydrazide, monohydrochloride, (2S-cis)-
  • ZORUBICIN HCL USP/EP/BP
  • 36508-71-1
  • C34H35N3O10HCl