ChemicalBook > CAS DataBase List > Ceftriaxone sodium

Ceftriaxone sodium

Product Name
Ceftriaxone sodium
CAS No.
104376-79-6
Chemical Name
Ceftriaxone sodium
Synonyms
Rosihlitazone;CEFTRIAXONE NA;RO-13-9904/001;Hemiheptahydrate;ROCEFIN ROCEPHINE;CEFTRIASONE SODIUM;Ceftriaxone （USP34 ）;Ceftriaxone Sodium RS;CEFTRIAXONE SODIUM INJ;Ceftriaxone sodium CRS
CBNumber
CB3350760
Molecular Formula
C18H21N8NaO8S3
Formula Weight
596.58
MOL File
104376-79-6.mol
More
Less

Ceftriaxone sodium Property

Melting point:
236 °C
alpha 
D25 -165° (c = 1 in water) (calc for water-free substance)
refractive index 
-160 ° (C=1, H2O)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
H2O: soluble50mg/mL
pka
~3 (COOH), 3.2 (NH3+), 4.1 (enolic OH)
form 
powder or crystals
color 
White to Off-White
Water Solubility 
Freely soluble in water
InChIKey
FDRNWTJTHBSPMW-BBJOQENWSA-L
SMILES
C(C1=C(CS[C@]2([H])[C@H](NC(=O)/C(/C3N=C(N)SC=3)=N\OC)C(=O)N12)CSC1=NC(=O)C(=O)NN1C)(=O)O.[NaH].O |&1:5,7,r|
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
36/37/38-42/43
Safety Statements 
26-36-45-37-24-22
WGK Germany 
1
RTECS 
XI0368800
HS Code 
29349990
Toxicity
LD50 in male, female, mice, rats (mg/kg): 3000, 2800, 2175, 2175 i.v.; >10000 all species orally; >5000 all species s.c. (Teelman)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C5793
Product name
Ceftriaxone disodium salt hemi(heptahydrate)
Purity
third-generation cephalosporin antibiotic
Packaging
1g
Price
$361
Updated
2025/07/31
Sigma-Aldrich
Product number
C0691000
Product name
Ceftriaxone sodium
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
100 mg
Price
$236
Updated
2025/07/31
Sigma-Aldrich
Product number
1098184
Product name
Ceftriaxone sodium
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
350mg
Price
$425
Updated
2025/07/31
TCI Chemical
Product number
C2226
Product name
Ceftriaxone Disodium Salt Hemiheptahydrate
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$87
Updated
2025/07/31
TCI Chemical
Product number
C2226
Product name
Ceftriaxone Disodium Salt Hemiheptahydrate
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$250
Updated
2025/07/31
More
Less

Ceftriaxone sodium Chemical Properties,Usage,Production

Description

Ceftriaxone is a third-generation, broad-spectrum cephalosporin antibiotic that disrupts the synthesis of the peptidoglycan layer of bacterial cell walls. It has been shown to increase excitatory amino acid transporter-2 pump expression in the central nervous system and to reduce glutamatergic toxicity in both in vitro and in vivo models.

Chemical Properties

White Crystalline Solid

Uses

antipsychotic

Uses

A potentially useful antibacterial agent for proteomics research.

Uses

An antibacterial, a third-generation cephalosporin.

Definition

ChEBI: Ceftriaxone disodium salt hemiheptahydrate is a cephalosporin.

brand name

Rocephin (Roche).

Biological Activity

β -lactam antibiotic. Displays neuroprotective activity in vivo via upregulation and increased activity of the EAAT2 glutamate transporter.

References

[1] H. NEU F KWUNGP N Meropol. Antibacterial Activity of Ceftriaxone (Ro 13-9904), a β-Lactamase-Stable Cephalosporin[J]. Antimicrobial Agents and Chemotherapy, 1981, 19 1: 940-940. DOI: 10.1128/aac.19.5.940-b
[2] SIZHUANG YAN  Dennis L S  Paul M Mendelman. The in vitro antibacterial activity of ceftriaxone against Streptococcus pyogenes is unrelated to penicillin-binding protein 4[J]. Fems Microbiology Letters, 1993, 110 3: Pages 313-317.

Ceftriaxone sodium Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Ceftriaxone sodium Suppliers

Americas 1 Argentina 1 Belgium 1 Canada 2 China 311 Europe 5 France 1 Germany 7 India 30 Italy 2 Japan 2 Poland 1 South Korea 4 Switzerland 1 United Arab Emirates 1 United Kingdom 13 United States 42 Global 425
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19552
Advantage
58
Cato Research Chemicals Inc.
Tel
+86-020-81960175-877 4000-868-328
Email
tianwen.zhan@cato-chem.com
Country
United States
ProdList
10404
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Dimysh ( ShangHai ) Trading Co., Ltd.
Tel
--
Fax
--
Email
sales@dmschemical.com
Country
United States
ProdList
90
Advantage
0
TOKU-E Company
Tel
--
Fax
--
Email
info@toku-e.com
Country
United States
ProdList
320
Advantage
50
Abcam Limited
Tel
--
Fax
--
Email
us.orders@abcam.com
Country
United States
ProdList
6001
Advantage
50
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
MilliporeSigma (Sigma-Aldrich Corp.)
Tel
--
Fax
--
Email
@sial.com
Country
United States
ProdList
5414
Advantage
58
Selleck Chemicals LLC
Tel
--
Fax
--
Email
sales@selleckchem.com
Country
United States
ProdList
1848
Advantage
58
OChem Incorporation
Tel
--
Fax
--
Email
sales@ocheminc.com
Country
United States
ProdList
6501
Advantage
60
RIA International LLC
Tel
--
Fax
--
Email
marketing@riausa.net
Country
United States
ProdList
1324
Advantage
50
Spectrum Chemical Mfg. Corp.
Tel
--
Fax
--
Email
marketing@spectrumchemical.com
Country
United States
ProdList
3113
Advantage
60
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6962
Advantage
56
W & J PharmaChem, Inc.
Tel
--
Fax
--
Email
info@wjpharmachem.com
Country
United States
ProdList
595
Advantage
50
AlliChem, LLC
Tel
--
Fax
--
Email
sales@allichemllc.com
Country
United States
ProdList
6516
Advantage
60
Medical Isotopes
Tel
--
Fax
--
Email
stohler@medicalisotopes.com
Country
United States
ProdList
6181
Advantage
68
Ivy Fine Chemicals
Tel
--
Fax
--
Email
sales@ivychem.com
Country
United States
ProdList
6493
Advantage
58
Advance Scientific & Chemical
Tel
--
Fax
--
Email
sales@advance-scientific.com
Country
United States
ProdList
6419
Advantage
71
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
APAC Pharmaceutical, LLC
Tel
--
Fax
--
Email
sales@apacpharma.com
Country
United States
ProdList
6322
Advantage
38
SynFine Research
Tel
--
Fax
--
Email
research@synfine.com
Country
United States
ProdList
1024
Advantage
68
Sciencelab.com, Inc.
Tel
--
Fax
--
Email
accounting@sciencelab.com
Country
United States
ProdList
4159
Advantage
82
Beta Pharma, Inc.
Tel
--
Fax
--
Email
sales@betapharma.com
Country
United States
ProdList
6226
Advantage
60
Chem-Impex International, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6730
Advantage
64
LKT Laboratories, Inc.
Tel
--
Fax
--
Email
info@lktlabs.com
Country
United States
ProdList
2164
Advantage
64
Spectrum Chemicals & Laboratory Products
Tel
--
Fax
--
Email
sales@spectrumchemical.com
Country
United States
ProdList
6699
Advantage
77
ChemPacific Corporation
Tel
--
Fax
--
Email
sales@chempacific.com
Country
United States
ProdList
6891
Advantage
51
BOSCHE SCIENTIFIC, LLC
Tel
--
Fax
--
Email
Sales@BoscheSci.com
Country
United States
ProdList
6477
Advantage
55
American Custom Chemicals Corporation
Tel
--
Fax
--
Email
sales@acccorporation.com
Country
United States
ProdList
6820
Advantage
51
CGeneTech, Inc.
Tel
--
Fax
--
Email
qyu@cgenetech.com
Country
United States
ProdList
959
Advantage
30
More
Less

View Lastest Price from Ceftriaxone sodium manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
Ceftriaxone Sodium 104376-79-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kg
Release date
2025-12-09
Sinoway Industrial co., ltd.
Product
Ceftriaxone sodium 104376-79-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20tons
Release date
2024-05-15
Hebei Chuanghai Biotechnology Co., Ltd
Product
Ceftriaxone Sodium 104376-79-6
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10mt
Release date
2025-03-10

104376-79-6, Ceftriaxone sodiumRelated Search:

(6R-trans)-7-amino-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Thiotriazinone Cephalothin sodium Cefotaxime sodium 3-Desacetyl CefotaxiMe Lactone (E)-Ceftriaxone Ceftriaxone Sodium intermediate CEFTRIAXONE SODIUM, USP Ceftriaxone sodium CEFTRIAXONE IMPURITY A CEFTRIAXONE SODIUM E-ISOMER (25 MG) Ceftriaxone Sodium sterile USP/EP/JP Ceftriaxone sodium Non sterile(crude) Ceftriaxone sodium (crude) In-house Spec 25kg/box Ceftriaxone sodium (solvent crystallization of sterile BPC) CHP 、USP、EP 5kg/tin、2tin/box Ceftriaxone sodium crude,non-sterile,crystalline,sterile Ceftriaxone sodium crystalline.sterile 7-ACT / for Ceftriaxone Sodium

  • (6R,7R)-7-[[(2Z)-2-(2-AMino-4-thiazolyl)-2-(MethoxyiMino)acetyl]aMino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-Methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]Methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid SodiuM Salt Hydrate
  • Ceftriaxone sodiuM sesquaterhydrate
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-, sodium salt, hydrate (2:4:7), (6R,7R)-
  • Ceftriaxone SodiuM Trihydrate
  • Ceftriaxone disodium salt hemiheptahydrate, >=98%
  • sodium 7-[[2-(2-amino-4-thiazolyl)-2-methoxyimino-1-oxoethyl]amino]-3-[[(2-methyl-5,6-dioxo-1H-1,2,4-triazin-3-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-, sodium salt, hydrate (2:
  • Ceftriaxone (sodium salt hydrate)
  • Ceftriaxone Disodium Salt&nbsp
  • Hemiheptahydrate
  • Ceftriaxone hemi(heptahydrate) disodium salt
  • CEFTRIASONE SODIUM
  • Rosihlitazone
  • [6R-[6α,7β(Z)]]-7-[[(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt
  • (6R,7R)-7-[(Z)-2-2(2-Amino-4-thiazolyl)-2-(methoxyimino)azetamido]-3-{[(2,5-dihydro-6-hydroxy-2-methyl-5-oxo-as-triazin-3-yl)thio]methyl}-8-oxo-5-thia-1-aza-bicyclo-[4.2.0]oct-2-en-2-carbonsure-dinatriumsalz
  • Disodium salt hemiheptahydrate
  • 7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicaciddisodiumsalt
  • Ceftriaxone Sodium (350 mg)G1D265925ug/mg(an)
  • Ceftriaxone Sodium (350 mg)
  • CEFTRIAXONE, DISODIUM SALT, HEMIHEPTAHYDRATE
  • CEFTRIAXONE NA
  • CEFTRIAXONE SODIUM HYDRATE
  • CEFTRIAXONE SODIUM SALT
  • (6r,7r)-7-[2-(2-amino-4-thiazolyl)glyoxylamido]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-as-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt
  • ROCEFIN ROCEPHINE
  • RO-13-9904/001
  • CeftriaxoneSodiumSterileUsp26
  • Ro-13-9904/001, Rocefin Rocephine
  • CEFTRIAXONE SODIUM FOR INJECTION
  • CEFTRIAXONE SODIUM INJ
  • Ceftriaxone Sodium(Nonsterile)
  • Ceftriaxone sodium sterile
  • Ceftriaxone Disodium Salt Hemiheptahydrate Standard
  • Ceftriaxone sodium CRS
  • Ceftriaxone Sodium Hemiheptahydrate
  • Ceftriaxone Disodium Salt Hemiheptahydrate&gt
  • Ceftriaxone disodium hemiheptahydrate
  • (6R,7R)-7-((Z)-2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-(((2-methyl-5,6-dioxo-1,2,5,6-tetrahydro-1,2,4-triazin-3-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, disodium salt,Hemiheptahydrate
  • Ceftriaxone sodium hydrate (2:4:7)
  • Ceftriaxone sodium USP/EP/BP
  • Ceftriaxone disodium hemiheptahydrate, 5...
  • Ceftriaxone Disodium Salt Hemiheptahydrate (CFTZ)
  • Ceftriaxone Sodium (1098184)
  • Ceftriaxone Sodium Trihydrate|||Ceftriaxone disodium hemiheptahydrate|||Ceftriaxone sodium
  • Ceftriaxone disodium salt hemiheptahydrate in acetonitrile
  • Ceftriaxone disodium salt hemiheptahydrate in methanol
  • Ceftriaxone sodium 3.5 hydrate
  • Ceftriaxone disodium salt hemi(heptahydrate), beta-Lactam antibiotic
  • Ceftriaxone sodium hydrate, 10 mM in DMSO
  • Ceftriaxone sodium hydrate - Bio-X ?
  • Ceftriaxone （USP34 ）
  • Ceftriaxone Sodium RS
  • Ceftriaxone Sodium Hemitrihydrate
  • 104376-79-6
  • 74578-59-1
  • 12-95-1
  • C18H16N8O7S372H2O2Na
  • C18H17N8NaO7S3