ChemicalBook > CAS DataBase List > CGS 15943

CGS 15943

Product Name
CGS 15943
CAS No.
104615-18-1
Chemical Name
CGS 15943
Synonyms
CGS 15943;CGS-15943A;CGS-15943 solid;CGS-15943 ADENOSINE A1 RECEPTOR;9-CHLORO-2-(2-FURYL)(1,2,4)TRIAZOLO(1,5-C)QUINAZOLIN-5-AMINE;9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine;9-Chloro-2-(furan-2-yl)[1,2,4]triazolo[1,5-c]quinazolin-5-amine;9-CHLORO-2-(2-FURANYL)-[1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINE;[1,2,4]Triazolo[1,5-c]quinazolin-5-amine,9-chloro-2-(2-furanyl)-;9-Chloro-5,6-dihydro-2-(furan-2-yl)[1,2,4]triazolo[1,5-c]quinazolin-5-imine
CBNumber
CB3351424
Molecular Formula
C13H8ClN5O
Formula Weight
285.69
MOL File
104615-18-1.mol
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CGS 15943 Property

Melting point:
278-279 °C
Density 
1.72±0.1 g/cm3(Predicted)
storage temp. 
room temp
solubility 
DMSO: >16 mg/mL
form 
solid
pka
1.23±0.30(Predicted)
color 
white
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C199
Product name
CGS-15943
Purity
solid
Packaging
25mg
Price
$160
Updated
2024/03/01
Alfa Aesar
Product number
J61313
Product name
CGS 15943, 99+%
Packaging
10mg
Price
$94.8
Updated
2021/12/16
Alfa Aesar
Product number
J61313
Product name
CGS 15943, 99+%
Packaging
50mg
Price
$327
Updated
2021/12/16
Cayman Chemical
Product number
22073
Product name
CGS 15943
Purity
≥95%
Packaging
5mg
Price
$33
Updated
2024/03/01
Cayman Chemical
Product number
22073
Product name
CGS 15943
Purity
≥95%
Packaging
10mg
Price
$62
Updated
2024/03/01
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CGS 15943 Chemical Properties,Usage,Production

Uses

Potent adenosine receptor antagonist

Definition

ChEBI: A member of the class of triazoloquinazolines that is [1,2,4]triazolo[1,5-c]quinazoline substited at positions 2, 5 and 9 by furan-2-yl, amino and chloro groups respectively. A potent antagonist at adenosine A1 and adenosi e A2A receptors.

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 27, p. 1549, 1990 DOI: 10.1002/jhet.5570270605

Biological Activity

Potent adenosine receptor antagonist (K i values are 3.5, 4.2, 16 and 51 nM for human A 1 , A 2A , A 2B and A 3 receptors respectively). Orally active in vivo .

Biochem/physiol Actions

CGS-15943 is a potent and non-selective adenosine receptor antagonist. It exhibits anti-carcinogenic and anti-apoptotic activity.

storage

Store at RT

CGS 15943 Preparation Products And Raw materials

Raw materials

Preparation Products

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CGS 15943 Suppliers

China 64 Europe 1 Germany 2 Switzerland 1 United Kingdom 2 United States 11 USA 1 Global 82
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104615-18-1, CGS 15943Related Search:

1H-1,2,4-Triazole-1-carboximidamide hydrochloride N,N-didemethylchlordimeform MRS 1220 N-(4-Chlorophenyl)guanidine CGS 15943

  • 9-CHLORO-2-(2-FURYL)(1,2,4)TRIAZOLO(1,5-C)QUINAZOLIN-5-AMINE
  • 9-CHLORO-2-(2-FURANYL)-[1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINE
  • CGS-15943 ADENOSINE A1 RECEPTOR
  • CGS 15943
  • 9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine
  • 9-Chloro-2-(furan-2-yl)[1,2,4]triazolo[1,5-c]quinazolin-5-amine
  • 9-Chloro-5,6-dihydro-2-(furan-2-yl)[1,2,4]triazolo[1,5-c]quinazolin-5-imine
  • CGS-15943A
  • [1,2,4]Triazolo[1,5-c]quinazolin-5-amine,9-chloro-2-(2-furanyl)-
  • CGS-15943 solid
  • Adenosine Receptor,CGS-15943,Phosphoinositide 3-kinase,P1 receptor,PI3K,inhibit,CGS15943,CGS 15943,Inhibitor
  • 9-Chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine , CGS 15943
  • 104615-18-1
  • C13H8ClN5O
  • Adenosine receptor