ChemicalBook > CAS DataBase List > 1,2-DIBROMO-4,5-(METHYLENEDIOXY)BENZENE

1,2-DIBROMO-4,5-(METHYLENEDIOXY)BENZENE

Product Name: 1,2-DIBROMO-4,5-(METHYLENEDIOXY)BENZENE
CAS No.: 5279-32-3
Chemical Name: 1,2-DIBROMO-4,5-(METHYLENEDIOXY)BENZENE
Synonyms: 5,6-Dibromobenzo[d][1,3]dioxole;5,6-DIBROMO-1,3-BENZODIOXOLE;5,6-DIBROMO-BENZO(1,3)DIOXOLE;1,3-Benzodioxole, 5,6-dibromo-;3-(trifluoromethyl)sulphanylaniline;4,5-Methylenedioxy-1,2-dibromobenzene;4,5-Dibromo-1,2-methylenedioxybenzene;1,2-DIBROMO-4,5-(METHYLENEDIOXY)BENZENE;5,6-Dibromo-1,3-benzodioxole~4,5-Methylenedioxy-1,2-dibromobenzene
CBNumber: CB3351828
Molecular Formula: C7H4Br2O2
Formula Weight: 279.91
MOL File: 5279-32-3.mol

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1,2-DIBROMO-4,5-(METHYLENEDIOXY)BENZENE Property

Melting point:: 83-85°C
Boiling point:: 294.7±40.0 °C(Predicted)
Density: 2.104±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml; Ethanol: 10 mg/ml
form: A crystalline solid
color: Off-white to light brown
BRN: 145633

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Safety

Hazard Codes: Xi
Safety Statements: 22-24/25
HS Code: 2932.99.7000
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S53598
Product name: 5,6-DIBROMO-BENZO(1,3)DIOXOLE
Purity: Aldrich<sup>CPR</sup>
Packaging: 1 unit
Price: $185
Updated: 2025/07/31

Sigma-Aldrich

Product number: S53598
Product name: 5,6-DIBROMO-BENZO(1,3)DIOXOLE
Purity: Aldrich
Packaging: 100mg
Price: $179
Updated: 2024/03/01

TCI Chemical

Product number: D4737
Product name: 5,6-Dibromo-1,3-benzodioxole
Purity: >98.0%(GC)
Packaging: 1g
Price: $38
Updated: 2025/07/31

TCI Chemical

Product number: D4737
Product name: 5,6-Dibromo-1,3-benzodioxole
Purity: >98.0%(GC)
Packaging: 5g
Price: $113
Updated: 2025/07/31

Cayman Chemical

Product number: 26357
Product name: 1,2-Dibromo-4,5-methylenedioxybenzene
Packaging: 5mg
Price: $44
Updated: 2024/03/01

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1,2-DIBROMO-4,5-(METHYLENEDIOXY)BENZENE Chemical Properties,Usage,Production

Uses

1,2-Dibromo-4,5-methylenedioxybenzene is an impurity in the synthesis of amphetamines[1].

Synthesis

75-09-2

2563-26-0

5279-32-3

Dichloromethane (762 μL, 11.94 mmol) was added dropwise to a stirred solution of 4,5-dibromobenzene-1,2-diol (2.00 g, 7.46 mmol) and cesium carbonate (3.89 g, 11.94 mmol) in N,N-dimethylformamide (DMF, 75 mL), and the reaction was carried out at room temperature. Subsequently, the reaction mixture was heated to 120 °C and maintained for 2 h, after which it was cooled to room temperature. Upon completion of the reaction, the reaction was quenched by the addition of water (150 mL), and the resulting solution was extracted several times with ethyl acetate (EtOAc, 5 × 100 mL). The organic phases were combined, washed sequentially with water (5×150 mL) and saturated brine (2×150 mL), dried over anhydrous sodium sulfate (Na2SO4), and concentrated under reduced pressure to remove the solvent. Finally, the product was purified by silica gel column chromatography eluting with a gradient of petroleum ether (PET)/ethyl ether (Et2O) (100:0 to 95:5) to afford 5,6-dibromobenzo[d][1,3]dioxole (1.54 g, 5.50 mmol, 74% yield) as a white crystalline solid.

References

[1] Heather E, et al. Organic impurity profiling of 3,4-methylenedioxymethamphetamine (MDMA) synthesised from catechol. Forensic Sci Int. 2015 Mar;248:140-7. DOI:10.1016/j.forsciint.2014.12.021

1,2-DIBROMO-4,5-(METHYLENEDIOXY)BENZENE Preparation Products And Raw materials

Raw materials

Preparation Products

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1,2-DIBROMO-4,5-(METHYLENEDIOXY)BENZENE Suppliers

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View Lastest Price from 1,2-DIBROMO-4,5-(METHYLENEDIOXY)BENZENE manufacturers

Career Henan Chemical Co

Product: 1,2-DIBROMO-4,5-(METHYLENEDIOXY)BENZENE 5279-32-3
Price: US $9.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg -1000kg
Release date: 2020-01-02

5279-32-3, 1,2-DIBROMO-4,5-(METHYLENEDIOXY)BENZENERelated Search:

Piperine 1,2-Dibromobenzene 1,2-DIBROMO-4,5-METHYLENEDIOXY- BENZENE = (4,5-METHYLENEDIOXY-1,2-DIBROMO-BENZENE 1,2-DIBROMO-4,5-METHYLENEDIOXY- BENZENE, (4,5-METHYLENEDIOXY-1,2-DIBROMO-BENZENE 4-Bromo-1,2-(methylenedioxy)benzene 1,2-DIBROMO-4,5-(METHYLENEDIOXY)BENZENE 3,4-Dibromoanisole 4,5-Dibromo-1,2-benzenediol

5,6-DIBROMO-1,3-BENZODIOXOLE

5,6-Dibromo-1,3-benzodioxole~4,5-Methylenedioxy-1,2-dibromobenzene

4,5-Methylenedioxy-1,2-dibromobenzene

5,6-DIBROMO-BENZO(1,3)DIOXOLE

5,6-Dibromobenzo[d][1,3]dioxole

1,2-DIBROMO-4,5-(METHYLENEDIOXY)BENZENE

1,3-Benzodioxole, 5,6-dibromo-

4,5-Dibromo-1,2-methylenedioxybenzene

3-(trifluoromethyl)sulphanylaniline

5279-32-3