N,N-DIISOPROPYLFORMAMIDE

N,N-DIISOPROPYLFORMAMIDE Property

Melting point:

10-11 °C (lit.)

Boiling point:

196 °C (lit.)

Density 

0.89 g/mL at 25 °C (lit.)

vapor pressure 

58.5hPa at 37.8℃

refractive index 

n20/D 1.437(lit.)

Flash point:

167 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform, Methanol (Slightly)

form 

Oil

pka

-0.56±0.70(Predicted)

color 

Colourless

Water Solubility 

Slightly soluble in water.

BRN 

1745406

InChIKey

UNBDDZDKBWPHAX-UHFFFAOYSA-N

LogP

1.077 at 30℃

CAS DataBase Reference

2700-30-3(CAS DataBase Reference)

Safety

Safety Statements 

23-24/25

WGK Germany 

3

RTECS 

OO3500000

HS Code 

29241900

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

N,N-DIISOPROPYLFORMAMIDE Chemical Properties,Usage,Production

Chemical Properties

CLEAR LIGHT BROWN LIQUID

Uses

N,N-Diisopropylformamide can be used for catalytic activity.

General Description

The chemical ionisation and electron ionisation mass spectroscopic data, retention indices and NMR spectra of N,N-diisopropylformamide was studied.

Flammability and Explosibility

Not classified

Synthesis

255.7 g of formic acid (equivalent to 38.3 g of water) and 99% pure diisopropylamine (460 g, 85% pure) were added to a 1 L autoclave, and stirring was initiated to ensure the formation of a homogeneous reaction system. The molar ratio of formic acid to diisopropylamine was controlled to be 1.05:1. Under continuous stirring, the reaction system was heated to about 200 °C, at which time the pressure in the autoclave was increased to about 1.7 MPa and stabilized, and the reaction conditions were maintained for about 3 hours. Upon completion of the reaction, the pressure in the autoclave was slowly released. Subsequently, carbon monoxide and water vapor generated during the reaction were collected and the reaction products were separated, resulting in about 709 g of a homogeneous and transparent N,N-diisopropylformamide solution.

References

[1] Research on Chemical Intermediates, 2013, vol. 39, # 6, p. 2843 - 2848
[2] Comptes Rendus Chimie, 2012, vol. 15, # 11-12, p. 980 - 987
[3] Bulletin of the Korean Chemical Society, 2010, vol. 31, # 10, p. 2989 - 2991
[4] Synlett, 2010, # 8, p. 1231 - 1234
[5] Synlett, 2010, # 14, p. 2093 - 2096