N-P-TOSYL-GLY-PRO-ARG P-NITROANILIDE ACETATE SALT

Product Name: N-P-TOSYL-GLY-PRO-ARG P-NITROANILIDE ACETATE SALT
CAS No.: 86890-95-1
Chemical Name: N-P-TOSYL-GLY-PRO-ARG P-NITROANILIDE ACETATE SALT
Synonyms: Einecs 289-285-2;Thrombin Substrate I;Tos-Gly-Pro-Arg-pNA Acetate;N-(p-Tosyl)-GPR-pNA (acetate);Tos-Gly-Pro-Arg-pNA acetate salt;N-(p-Tosyl)-Gly-Pro-Arg-pNA.Acetate;N-P-TOSYL-GLY-PRO-ARG P-NITROANILIDE;N-Tosyl-Gly-Pro-Arg 4-nitroanilide acetate;N-P-TOSYL-GLY-PRO-ARG P-NITROANILIDE*ACE TATE;Tosyl-Gly-Pro-Arg-(4-nitrophenyl)NH2·acetic acid
CBNumber: CB3374991
Molecular Formula: C28H38N8O9S
Formula Weight: 662.71
MOL File: 86890-95-1.mol

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N-P-TOSYL-GLY-PRO-ARG P-NITROANILIDE ACETATE SALT Property

storage temp.: −20°C
solubility: DMF: 20 mg/ml; DMSO: 3 mg/ml; PBS (pH 7.2): 3 mg/ml
form: A solid

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
F: 10-21

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 27568
Product name: N-(p-Tosyl)-GPR-pNA (acetate)
Packaging: 100mg
Price: $538
Updated: 2024/03/01

Cayman Chemical

Product number: 27568
Product name: N-(p-Tosyl)-GPR-pNA (acetate)
Packaging: 250mg
Price: $1116
Updated: 2023/06/20

Cayman Chemical

Product number: 27568
Product name: N-(p-Tosyl)-GPR-pNA (acetate)
Packaging: 25mg
Price: $159
Updated: 2024/03/01

Cayman Chemical

Product number: 27568
Product name: N-(p-Tosyl)-GPR-pNA (acetate)
Packaging: 50mg
Price: $301
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: PEP0004334
Product name: N-(P-TOSYL)-GLY-PRO-ARG P-NITROANILIDE ACETATE SALT
Purity: 95.00%
Packaging: 1MG
Price: $595.1
Updated: 2021/12/16

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N-P-TOSYL-GLY-PRO-ARG P-NITROANILIDE ACETATE SALT Chemical Properties,Usage,Production

Description

N-(p-Tosyl)-GPR-pNA is a colorimetric substrate for thrombin. Thrombin preferentially binds to and cleaves the Gly-Pro-Arg (GPR) peptide sequence to release p-nitroanilide (pNA), which can be quantified by colorimetric detection at 405 nm as a measure of thrombin activity.

Uses

N-(p-Tosyl)-GPR-pNA acetate (Chromozym-TH) is a chromogenic substrate targeting the synthetic peptides Hirunorm IV and Hirunorm V and can be used to detect the dissociation constants (KI) of both peptides. Hirunorm IV and Hirunorm V are reversible inhibitors of amidolytic thrombin activity. By varying the peptide concentration at a fixed concentration of the chromogenic substrate N-(p-Tosyl)-GPR-pNA acetate, the dissociation constants determined were 0.134 nM (Hirunorm IV) and 0.245 nM (Hirunorm V)[1].

References

[1] Cappiello M, et al. Kinetics of human thrombin inhibition by two novel peptide inhibitors (Hirunorm IV and Hirunorm V). Biochem Pharmacol. 1996 Oct 25;52(8):1141-6. DOI:10.1016/0006-2952(96)00388-7

N-P-TOSYL-GLY-PRO-ARG P-NITROANILIDE ACETATE SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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N-P-TOSYL-GLY-PRO-ARG P-NITROANILIDE ACETATE SALT Suppliers

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86890-95-1, N-P-TOSYL-GLY-PRO-ARG P-NITROANILIDE ACETATE SALTRelated Search:

butyl[(1-ethylpyrrolidin-2-yl)methyl]amine N-P-TOSYL-GLY-PRO-ARG P-NITROANILIDE ACETATE SALT chromozym TH N-(2-aminoethyl)-4-methyl-benzenesulfonamide H-ALA-ALA-PNA Z-GLY-PRO-ARG-4M-BETANA ACETATE SALT

N-P-TOSYL-GLY-PRO-ARG P-NITROANILIDE ACETATE SALT

N-TOSYLGLYCYL-L-PROLYL-L-ARGININE 4-NITROANILIDE ACETATE

N-tosylglycyl-L-prolyl-L-arginine 4-nitroanilide acetat

N-tosylglycyl-L-prolyl-N-(p-nitrophenyl)-L-argininamide monoacetate

N-P-TOSYL-GLY-PRO-ARG P-NITROANILIDE*ACE TATE

N-Tosyl-Gly-Pro-Arg 4-nitroanilide acetate

n-tosylglycyl-l-prolyl-l-arginine 4-nitroanilide acetate salt

Tosyl-Gly-Pro-Arg-(4-nitrophenyl)NH2·acetic acid

Einecs 289-285-2

L-Argininamide, N-((4-methylphenyl)sulfonyl)glycyl-L-propyl-N-(4-nitrophenyl)-, monoacetate

Thrombin Substrate I

N-(p-Tosyl)-GPR-pNA (acetate)

N-P-TOSYL-GLY-PRO-ARG P-NITROANILIDE

N (p Tosyl) GPR pNA acetate,N(pTosyl)GPRpNA acetate

N-(p-Tosyl)-Gly-Pro-Arg-pNA.Acetate

Tos-Gly-Pro-Arg-pNA acetate salt

Tos-Gly-Pro-Arg-pNA Acetate

86890-95-1

C26H34N8O7SCH3COOH

C26H34N8O7SC2H4O2

BioChemical

Biochemicals and Reagents

Plasma & Blood Proteins

Proteins and Derivatives

Substrates by Enzyme

Enzymes, Inhibitors, and Substrates

Coagulation Proteins and Reagents

Enzyme Substrates