ChemicalBook > CAS DataBase List > N-P-TOSYL-GLY-PRO-ARG P-NITROANILIDE ACETATE SALT

N-P-TOSYL-GLY-PRO-ARG P-NITROANILIDE ACETATE SALT

Product Name
N-P-TOSYL-GLY-PRO-ARG P-NITROANILIDE ACETATE SALT
CAS No.
86890-95-1
Chemical Name
N-P-TOSYL-GLY-PRO-ARG P-NITROANILIDE ACETATE SALT
Synonyms
Einecs 289-285-2;Thrombin Substrate I;Tos-Gly-Pro-Arg-pNA Acetate;N-(p-Tosyl)-GPR-pNA (acetate);Tos-Gly-Pro-Arg-pNA acetate salt;N-(p-Tosyl)-Gly-Pro-Arg-pNA.Acetate;N-P-TOSYL-GLY-PRO-ARG P-NITROANILIDE;N-Tosyl-Gly-Pro-Arg 4-nitroanilide acetate;N-P-TOSYL-GLY-PRO-ARG P-NITROANILIDE*ACE TATE;Tosyl-Gly-Pro-Arg-(4-nitrophenyl)NH2·acetic acid
CBNumber
CB3374991
Molecular Formula
C28H38N8O9S
Formula Weight
662.71
MOL File
86890-95-1.mol
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N-P-TOSYL-GLY-PRO-ARG P-NITROANILIDE ACETATE SALT Property

storage temp. 
−20°C
solubility 
DMF: 20 mg/ml; DMSO: 3 mg/ml; PBS (pH 7.2): 3 mg/ml
form 
A solid
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
F 
10-21
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
27568
Product name
N-(p-Tosyl)-GPR-pNA (acetate)
Packaging
100mg
Price
$538
Updated
2024/03/01
Cayman Chemical
Product number
27568
Product name
N-(p-Tosyl)-GPR-pNA (acetate)
Packaging
250mg
Price
$1116
Updated
2023/06/20
Cayman Chemical
Product number
27568
Product name
N-(p-Tosyl)-GPR-pNA (acetate)
Packaging
25mg
Price
$159
Updated
2024/03/01
Cayman Chemical
Product number
27568
Product name
N-(p-Tosyl)-GPR-pNA (acetate)
Packaging
50mg
Price
$301
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
PEP0004334
Product name
N-(P-TOSYL)-GLY-PRO-ARG P-NITROANILIDE ACETATE SALT
Purity
95.00%
Packaging
1MG
Price
$595.1
Updated
2021/12/16
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N-P-TOSYL-GLY-PRO-ARG P-NITROANILIDE ACETATE SALT Chemical Properties,Usage,Production

Description

N-(p-Tosyl)-GPR-pNA is a colorimetric substrate for thrombin. Thrombin preferentially binds to and cleaves the Gly-Pro-Arg (GPR) peptide sequence to release p-nitroanilide (pNA), which can be quantified by colorimetric detection at 405 nm as a measure of thrombin activity.

Uses

N-(p-Tosyl)-GPR-pNA acetate (Chromozym-TH) is a chromogenic substrate targeting the synthetic peptides Hirunorm IV and Hirunorm V and can be used to detect the dissociation constants (KI) of both peptides. Hirunorm IV and Hirunorm V are reversible inhibitors of amidolytic thrombin activity. By varying the peptide concentration at a fixed concentration of the chromogenic substrate N-(p-Tosyl)-GPR-pNA acetate, the dissociation constants determined were 0.134 nM (Hirunorm IV) and 0.245 nM (Hirunorm V)[1].

References

[1] Cappiello M, et al. Kinetics of human thrombin inhibition by two novel peptide inhibitors (Hirunorm IV and Hirunorm V). Biochem Pharmacol. 1996 Oct 25;52(8):1141-6. DOI:10.1016/0006-2952(96)00388-7

N-P-TOSYL-GLY-PRO-ARG P-NITROANILIDE ACETATE SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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N-P-TOSYL-GLY-PRO-ARG P-NITROANILIDE ACETATE SALT Suppliers

China 37 Germany 1 Switzerland 2 United Kingdom 1 United States 6 Global 47
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71

86890-95-1, N-P-TOSYL-GLY-PRO-ARG P-NITROANILIDE ACETATE SALTRelated Search:

butyl[(1-ethylpyrrolidin-2-yl)methyl]amine N-P-TOSYL-GLY-PRO-ARG P-NITROANILIDE ACETATE SALT chromozym TH N-(2-aminoethyl)-4-methyl-benzenesulfonamide H-ALA-ALA-PNA Z-GLY-PRO-ARG-4M-BETANA ACETATE SALT

  • N-P-TOSYL-GLY-PRO-ARG P-NITROANILIDE ACETATE SALT
  • N-TOSYLGLYCYL-L-PROLYL-L-ARGININE 4-NITROANILIDE ACETATE
  • N-tosylglycyl-L-prolyl-L-arginine 4-nitroanilide acetat
  • N-tosylglycyl-L-prolyl-N-(p-nitrophenyl)-L-argininamide monoacetate
  • N-P-TOSYL-GLY-PRO-ARG P-NITROANILIDE*ACE TATE
  • N-Tosyl-Gly-Pro-Arg 4-nitroanilide acetate
  • n-tosylglycyl-l-prolyl-l-arginine 4-nitroanilide acetate salt
  • Tosyl-Gly-Pro-Arg-(4-nitrophenyl)NH2·acetic acid
  • Einecs 289-285-2
  • L-Argininamide, N-((4-methylphenyl)sulfonyl)glycyl-L-propyl-N-(4-nitrophenyl)-, monoacetate
  • Thrombin Substrate I
  • N-(p-Tosyl)-GPR-pNA (acetate)
  • N-P-TOSYL-GLY-PRO-ARG P-NITROANILIDE
  • N (p Tosyl) GPR pNA acetate,N(pTosyl)GPRpNA acetate
  • N-(p-Tosyl)-Gly-Pro-Arg-pNA.Acetate
  • Tos-Gly-Pro-Arg-pNA acetate salt
  • Tos-Gly-Pro-Arg-pNA Acetate
  • 86890-95-1
  • C26H34N8O7SCH3COOH
  • C26H34N8O7SC2H4O2
  • BioChemical
  • Biochemicals and Reagents
  • Plasma & Blood Proteins
  • Proteins and Derivatives
  • Substrates by Enzyme
  • Enzymes, Inhibitors, and Substrates
  • Coagulation Proteins and Reagents
  • Enzyme Substrates